University of Madeira

About: University of Madeira is a education organization based out in Funchal, Portugal. It is known for research contribution in the topics: Population & Dendrimer. The organization has 1014 authors who have published 2759 publications receiving 59457 citations.

Enhancing legume ecosystem services through an understanding of plant–pollinator interplay

Abstract: Legumes are bee-pollinated, but to a different extent. The importance of the plant-pollinator interplay (PPI), in flowering crops such as legumes lies in a combination of the importance of pollination for the production service and breeding strategies, plus the increasing urgency in mitigating the decline of pollinators through the development and implementation of conservation measures. To realize the full potential of the PPI, a multidisciplinary approach is required. This article assembles an international team of genebank managers, geneticists, plant breeders, experts on environmental governance and agro-ecology, and comprises several sections. The contributions in these sections outline both the state of the art of knowledge in the field and the novel aspects under development, and encompass a range of reviews, opinions and perspectives. The first three sections explore the role of PPI in legume breeding strategies. PPI based approaches to crop improvement can make it possible to adapt and re-design breeding strategies to meet both goals of: 1) optimal productivity, based on an efficient use of pollinators, and 2) biodiversity conservation. The next section deals with entomological aspects and focuses on the protection of the “pest control service” and pollinators in legume crops. The final section addresses general approaches to encourage the synergy between food production and pollination services at farmer field level. Two basic approaches are proposed: a) Farming with Alternative Pollinators (FAP) and b) Crop Design System (CDS).

A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo.

Abstract: The development of cost-effective targeted drug delivery systems for cancer chemotherapy still remains a great challenging task. Here, we describe the synthesis and characterization of multifunctional polyethylenimine (PEI) as an effective vehicle to load an anticancer drug doxorubicin (DOX) for in vivo targeted cancer therapy. In this study, PEI was sequentially conjugated with polyethylene glycol (PEG) monomethyl ether, PEGylated folic acid (FA), and fluorescein isothiocyanate (FI). This was followed by the acetylation of the remaining PEI surface amines. The formed FA-targeted multifunctional PEI (FA–mPEI) was used as a vehicle to encapsulate DOX. We show that the formed FA–mPEI/DOX complexes with each PEI encapsulating 6.9 DOX molecules are water dispersible and can sustainably release DOX in a pH-dependent manner, showing a higher release rate under acidic pH conditions than under physiological pH conditions. Furthermore, the complexes display specific therapeutic efficacy to cancer cells in vitro and a subcutaneous tumor model in vivo, and have good organ compatibility. The designed multifunctional PEI may be used as an effective vehicle for targeted cancer chemotherapy.

Structural Characterization of Lignin from Leaf Sheaths of “Dwarf Cavendish” Banana Plant

Abstract: Dioxane lignin (DL) isolated from leaf sheaths of banana plant (Musa acuminata Colla var. cavendish) and in situ lignin were submitted to a comprehensive structural characterization employing spect...

The Semantic Web and Its Applications

Abstract: 1. INTRODUCTION Currently, the World Wide Web is primarily composed of documents written in HTML (Hyper Text Markup Language), a language that is useful for publishing information. HTML is a set of " markup " symbols contained in a Web page intended for display on a Web browser. During the first decade of its existence, most of the information on the Web is designed only for human consumption. Humans can read Web pages and understand them, but their inherent meaning is not shown in a way that allows their interpretation by computers The information on the Web can be defined in a way that it can be used by computers not only for display purposes, but also for interoperability and integration between systems and applications. One way to enable machine-to-machine exchange and automated processing is to provide the information in such a way that computers can understand it. This is precisely the objective of the semantic Web – to make possible the processing of Web information by computers. " The Semantic Web is not a separate Web but an extension of the current one, in which information is given well-defined meaning, better enabling computers and people to work in cooperation. "