University of Madeira

About: University of Madeira is a education organization based out in Funchal, Portugal. It is known for research contribution in the topics: Population & Dendrimer. The organization has 1014 authors who have published 2759 publications receiving 59457 citations.

Factors influencing urban investment attractiveness: an FCM-SD approach

Abstract: The increasing concentration of populations in urban areas in recent decades has strengthened the interest in – and the importance given to – these zones. Cities have become quite attractive from investors’ point of view because of the wide array of opportunities and growing need for investment in urban areas. Thus, city strategic planning quite often requires an understanding of the determinants that attract investment to urban zones. This study sought to identify the factors that strengthen urban investment based on the knowledge of a panel of experts. Fuzzy cognitive mapping techniques were applied to understand the concepts and decision criteria included in the decision-support model and their cause-and-effect relationships. The results provide insights into which determinants most strongly influence urban investment, namely, infrastructure, supporting services, and political-administrative factors. Diverse scenarios at the intra- and inter-cluster levels were created to clarify the impacts of variable changes on the model developed. The findings were validated by both the expert panel members and the vice-president of the Portuguese Association of Real Estate Developers and Investors. Advantages and limitations of the proposed framework are presented, as well as recommendations for future research.

A non-invasive approach to explore the discriminatory potential of the urinary volatilome of invasive ductal carcinoma of the breast

Abstract: Worldwide, breast invasive ductal carcinoma (IDC) accounts for the majority of the reported cases of this form of cancer. IDC effective management, as for any form of cancer, would greatly benefit from early diagnosis. This, however, due to various socio-economic reasons, is very far for the reality in developing countries like India, where cancer diagnosis is often carried out at late stages when disease management is troublesome. With the present work, we aim to evaluate a simple analytical methodology to identify a set of volatile organic compounds (VOCs) in urine samples, as a biosignature for IDC. Using solid-phase microextraction followed by gas chromatography/mass spectrometry, a panel of 14 urinary VOCs was found to discriminate IDC (n = 65) from a healthy control (HC) group (n = 70) through multivariate statistical treatments. Furthermore, metabolic pathway analysis revealed various dysregulated pathways involved in IDC patients hinting that their detailed investigations could lead to novel mechanistic insights into the disease pathophysiology. In addition, we validated the expression pattern of five of these VOCs namely 2-ethyl-1-hexanol, isolongifolenone, furan, dodecanoic acid, 2-methoxy-phenol in another external cohort of 59 urinary samples (IDC = 32 and HC = 27) and found their expression pattern to be consistent with the primary sample set. To our knowledge, this is the first study exploring breast IDC volatome alterations in Indian patients.

Centile Curves and Reference Values for Height, Body Mass, Body Mass Index and Waist Circumference of Peruvian Children and Adolescents

Abstract: This study aimed to provide height, body mass, BMI and waist circumference (WC) growth centile charts for school-children, aged 4–17 years, from central Peru, and to compare Peruvian data with North-American and Argentinean references. The sample consisted of 8753 children and adolescents (4130 boys and 4623 girls) aged 4 to 17 years, from four Peruvian cities: Barranco, La Merced, San Ramon and Junin. Height, body mass and WC were measured according to standardized techniques. Centile curves for height, body mass, BMI and WC were obtained separately for boys and girls using the LMS method. Student t-tests were used to compare mean values. Overall boys have higher median heights than girls, and the 50th percentile for body mass increases curvilinearly from 4 years of age onwards. In boys, the BMI and WC 50th percentiles increase linearly and in girls, the increase presents a curvilinear pattern. Peruvian children are shorter, lighter and have higher BMI than their counterparts in the U.S. and Argentina; in contrast, age and sex-specific WC values are lower. Height, body mass and WC of Peruvian children increased with age and variability was higher at older ages. The growth patterns for height, body mass, BMI and WC among Peruvian children were similar to those observed in North-American and Argentinean peers.

Pointing with fingers, hands and arms for wearable computing

Abstract: Pointing is a fundamental enabling operation for human-computer interaction across a broad spectrum of scenarios. The paper presents a study exploring how to develop a pointing system for truly wearable, rather than hand-held, computing. It describes a Fitts' law study of pointing based on motions in free-space captured using an inertial sensor pack. It compares performance when the pack is held in the hand, mounted on the back of the hand and finally on the wrist. The results show a significant, but numerically small, advantage in using the hands over using the upper arm only. This suggests that for wearable tasks where pointing is relatively infrequent a wrist based sensor pack may well be sufficient to enable effective and usable interaction.

Fluorescent Phosphorus Dendrimers: Towards Material and Biological Applications

Abstract: Fluorescent derivatives of phosphorhydrazone dendrimers are reviewed. Diverse types of fluorophores have been used, such as pyrene, naphthol, anthracene, dansyl, diketone, phthalocyanine, maleimide, julolidine, rhodamine, fluorescein, or fluorene derivatives. The fluorescent groups can be located either as terminal groups on the surface, at the core, linked to the core (off-center), or to the branches of the dendritic structure. After fundamental research on their synthesis, these compounds have been used in the fields of catalysis, nanomaterials, OLEDs, sensors and biology/nanomedicine, in particular for monitoring transfection, or for their anti-inflammatory or anti-cancer properties.