University of Saint Mary

About: University of Saint Mary is a education organization based out in Leavenworth, Kansas, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 2276 authors who have published 2399 publications receiving 58990 citations. The organization is also known as: University of St. Mary & University of St Mary.

After a stroke: strategies to restore function and prevent complications

Abstract: Mortality and morbidity are high in elderly stroke patients. Early mobilization and prevention of stroke-related complications improve their ability to participate in a more intense and comprehensive rehabilitation program. An interdisciplinary approach to stroke rehabilitation restores functional loss, improves quality of life, and decreases long-term economic costs. Important parts of stroke rehabilitation include patient and family education, treatment of stroke-related complications, and prevention of recurrent stroke. A healthy and caring spouse, continence of bladder and bowel, and ability to feed oneself are the most positive predictors of stroke outcome.

Impact of age and vector construct on striatal and nigral transgene expression

Abstract: Therapeutic protein delivery using viral vectors has shown promise in preclinical models of Parkinson's disease (PD) but clinical trial success remains elusive. This may partially be due to a failure to include advanced age as a covariate despite aging being the primary risk factor for PD. We investigated transgene expression following intracerebral injections of recombinant adeno-associated virus pseudotypes 2/2 (rAAV2/2), 2/5 (rAAV2/5), 2/9 (rAAV2/9), and lentivirus (LV) expressing green fluorescent protein (GFP) in aged versus young adult rats. Both rAAV2/2 and rAAV2/5 yielded lower GFP expression following injection to either the aged substantia nigra or striatum. rAAV2/9-mediated GFP expression was deficient in the aged striatonigral system but displayed identical transgene expression between ages in the nigrostriatal system. Young and aged rats displayed equivalent GFP levels following LV injection to the striatonigral system but LV-delivered GFP was deficient in delivering GFP to the aged nigrostriatal system. Notably, age-related transgene expression deficiencies revealed by protein quantitation were poorly predicted by GFP-immunoreactive cell counts. Further, in situ hybridization for the viral CβA promoter revealed surprisingly limited tropism for astrocytes compared to neurons. Our results demonstrate that aging is a critical covariate to consider when designing gene therapy approaches for PD.

Robbers in the Classroom: A Deindividuation Exercise.

Abstract: (1985). Robbers in the Classroom: A Deindividuation Exercise. Teaching of Psychology: Vol. 12, No. 2, pp. 89-91.

The Limits of Fishery Cooperatives? Community Development and Rural Depopulation in Hokkaido, Japan

Abstract: This paper explores the interrelationships between rural out-migration, long-term resource decline and cooperative organization in the case of one fishing community in Hokkaido, Japan. Contrary to the experience of many other Japanese fishing communities, the three cooperatives in the community under study have not been able to develop a coherent response to crisis and decline. A combination of fishing group protectionism and organizational rigidity has limited the ability of fishing cooperatives to respond in a consensual, collective fashion to the needs of the community. It is argued that the single stakeholder nature of the cooperative and the entrenchment of inequitable resource allocation around contemporary developments in seaweed mariculture, have generated intracommunity divisions. These difficulties present obstacles to a community-focused reconstruction strategy both within and outside the fishery.