Showing papers by "University of Texas System published in 2007"

Common allele on chromosome 9 associated with coronary heart disease

Abstract: Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has had RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP).

Bone augmentation techniques.

Abstract: Background: The advent of osseointegration and advances in biomaterials and techniques have contributed to increased application of dental implants in the restoration of partial and completely edentulous patients. Often, in these patients, soft and hard tissue defects result from a variety of causes, such as infection, trauma, and tooth loss. These create an anatomically less favorable foundation for ideal implant placement. For prosthetic-driven dental implant therapy, reconstruction of the alveolar bone through a variety of regenerative surgical procedures has become predictable; it may be necessary prior to implant placement or simultaneously at the time of implant surgery to provide a restoration with a good long-term prognosis. Regenerative procedures are used for socket preservation, sinus augmentation, and horizontal and vertical ridge augmentation.Methods: A broad overview of the published findings in the English literature related to various bone augmentation techniques is outlined. A comprehensi...

Devices for use in transluminal and endoluminal surgery

Abstract: The present invention is a device and method of using a variety of laparoscopic or NOTES surgical tools at a confined or inaccessible space, e.g., an intra-abdominal surgical and NOTES tool inserted through a single incision through the skin or hollow viscus. Generally, the laparoscopic or NOTES surgical devices include a device body having a first side and a second side, wherein the first side includes a positioning mechanism and the second side includes one or more of a variety of laparoscopic or NOTES tools.

IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-β, NF-κB, and AP-1 activation

Abstract: Matrix metalloproteinases (MMPs) degrade collagen and mediate tissue remodeling. The novel cytokine IL-17 is expressed during various inflammatory conditions and modulates MMP expression. We invest...

Molecular biology of KSHV in relation to AIDS-associated oncogenesis.

Abstract: Discovered in 1994, Kaposi’s sarcoma-associated herpesvirus (KSHV) has been associated with four human malignancies including Kaposi’s sarcoma, primary effusion lymphoma, a subset of multicentric Castleman’s disease, and KSHV inflammatory cytokine syndrome. These malignancies mostly occur in immunocompromised patients including patients with acquired immunodeficiency syndrome and often cause significant mortality because of the lack of effective therapies. Significant progresses have been made to understand the molecular basis of KSHV infection and KSHV-induced oncogenesis in the last two decades. This chapter provides an update on the recent advancements focusing on the molecular events of KSHV primary infection, the mechanisms regulating KSHV life cycle, innate and adaptive immunity, mechanism of KSHV-induced tumorigenesis and inflammation, and metabolic reprogramming in KSHV infection and KSHV-transformed cells.

Ion beam delivery equipment and an ion beam delivery method

Abstract: The invention is intended to increase the number of patients treatable using one wheel having a thickness varied in the rotating direction to change energy of an ion beam passing the wheel. Ion beam delivery equipment for irradiating an ion beam to a patient for treatment comprises a beam generator for producing and accelerating the ion beam, an beam delivery nozzle including a range modulation wheel which has a predetermined thickness distribution in the rotating direction and is rotated on a travel passage of the ion beam generated from the beam generator to control a range of the ion beam, and an irradiation controller for controlling the beam producing and accelerating operation of the beam generator in accordance with the phase of rotation of the range modulation wheel.

Effect of abutment angulation on the strain on the bone around an implant in the anterior maxilla: a finite element study.

Abstract: Statement of problem Angled abutments are often used to restore dental implants placed in the anterior maxilla due to esthetic or spatial needs. The effect of abutment angulation on bone strain is unknown. Purpose The purpose of the current study was to measure and compare the strain distribution on the bone around an implant in the anterior maxilla using 2 different abutments by means of finite element analysis. Material and methods Two-dimensional finite element models were designed using software (ANSYS) for 2 situations: (1) an implant with a straight abutment in the anterior maxilla, and (2) an implant with an angled abutment in the anterior maxilla. The implant used was 4 × 13 mm (MicroThread). The maxillary bone was modeled as type 3 bone with a cortical layer thickness of 0.5 mm. Oblique loads of 178 N were applied on the cingulum area of both models. Seven consecutive iterations of mesh refinement were performed in each model to observe the convergence of the results. Results The greatest strain was found on the cancellous bone, adjacent to the 3 most apical microthreads on the palatal side of the implant where tensile forces were created. The same strain distribution was observed around both the straight and angled abutments. After several iterations, the results converged to a value for the maximum first principal strain on the bone of both models, which was independent of element size. Most of the deformation occurred in the cancellous bone and ranged between 1000 and 3500 microstrain. Small areas of cancellous bone experienced strain above the physiologic limit (4000 microstrain). Conclusions The model predicted a 15% higher maximum bone strain for the straight abutment compared with the angled abutment. The results converged after several iterations of mesh refinement, which confirmed the lack of dependence of the maximum strain at the implant-bone interface on mesh density. Most of the strain produced on the cancellous and cortical bone was within the range that has been reported to increase bone mass and mineralization.

Method and apparatus for determining vascular health conditions

Abstract: The present invention relates to assessing and measuring vascular and endothelial function. A vasostimulant is provided to a patient to stimulate hemodynamic activity in a selected extremity and vascular function is assessed by monitoring a change in a blood flow, skin temperature and/or blood oxygen content at the selected extremity and assessing the patient's vascular function based upon the monitoring.

Breast cancer brain metastases.

Abstract: Breast cancer is the most common malignancy in woman in the USA. Metastasis is a major cause of morbidity and mortality in breast cancer patients. Total incidence of brain metastases of breast cancer is about 30%. Because of the improvements in control of systemic disease, for example the successful use of Trastuzumab, and the consequent prolonged life span, the incidence of brain metastases is increasing in breast cancer patients. The progressive neurological disabilities not only impair the quality of life, but also decrease the survival in patients. However, current treatments are of limited effectiveness. This is partially caused by the unique structure of the blood brain barrier. So far very little is known about the mechanisms how breast cancer metastizes to the brain. Some studies showed that ErbB2 overexpression is associated with the brain metastatic phenotype. Other molecules, like vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs) and chemokine receptor CXCR4 are also involved in the metastasis of breast cancer cell to the brain. The current review will briefly overview the clinical features of brain metastasis of breast cancer and discusses the relationship of blood brain barrier and ErbB2 signal pathway to brain metastasis in breast cancer.

Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage

Abstract: Melatonin and its metabolites are potent antioxidants by virtue of their ability to scavenge both oxygen-based and nitrogen-based radicals and intermediates but also as a consequence of their ability to stimulate the activity of antioxidative enzymes. Melatonin also prevents electron leakage from the mitochondrial electron transport chain thereby diminishing free radical generation; this process is referred to as radical avoidance. The fact that melatonin and its metabolites are all efficient radical scavengers indicates that melatonin is a precursor molecule for a variety of intracellular reducing agents. In specific reference to the brain, melatonin also has an advantage over some other antioxidants given that it readily passes through the blood-brain-barrier. This, coupled with the fact that it and its by-products are particularly efficient detoxifiers of reactive species, make these molecules of major importance in protecting the brain from oxidative/nitrosative abuse. This review summarizes the literature on two brain-related situations, i.e., traumatic brain and spinal cord injury and ischemia/reperfusion, and the neurodegenerative disease, amyotrophic lateral sclerosis, where melatonin has been shown to have efficacy in abating neural damage. These, however, are not the only age-associated neurodegenerative states where melatonin has been found to be protective.

Localization to atherosclerotic plaque and biodistribution of biochemically derivatized superparamagnetic iron oxide nanoparticles (SPIONs) contrast particles for magnetic resonance imaging (MRI)

Abstract: Annexin V recognizes apoptotic cells by specific molecular interaction with phosphatidyl serine, a lipid that is normally sequestered in the inner leaflet of the cell membrane, but is translocated to the outer leaflet in apoptotic cells, such as foam cells of atherosclerotic plaque. Annexin V could potentially deliver carried materials (such as superparamagnetic contrast agents for magnetic resonance imaging) to sites containing apoptotic cells, such as high grade atherosclerotic lesions, so we administered biochemically-derivatized (annexin V) superparmagnetic iron oxide particles (SPIONs) parenterally to two related rabbit models of human atherosclerosis. We observe development of negative magnetic resonance imaging (MRI) contrast in atheromatous lesions and but not in healthy artery. Vascular targeting by annexin V SPIONs is atheroma-specific (i.e., does not occur in healthy control rabbits) and requires active annexin V decorating the SPION surface. Targeted SPIONs produce negative contrast at doses that are 2,000-fold lower than reported for non-specific atheroma uptake of untargeted superparamagnetic nanoparticles in plaque in the same animal model. Occlusive and mural plaques are differentiable. While most of the dose accumulates in liver, spleen, kidneys and bladder, annexin V SPIONs also partition rapidly and deeply into early apoptotic foamy macrophages in plaque. Contrast in plaque decays within 2 months, allowing MRI images to be replicated with a subsequent, identical dose of annexin V SPIONs. Thus, biologically targeted superparamagnetic contrast agents can contribute to non-invasive evaluation of cardiovascular lesions by simultaneously extracting morphological and biochemical data from them.

Algebraic Multigrid Methods (AMG) for the Efficient Solution of Fully Implicit Formulations in Reservoir Simulation

Abstract: A primary challenge for a new generation of reservoir simulators is the accurate description of multiphase flow in highly heterogeneous media and very complex geometries. However, many initiatives in this direction have encountered difficulties in that current solver technology is still insufficient to account for the increasing complexity of coupled linear systems arising in fully implicit formulations. In this respect, a few works have made particular progress in partially exploiting the physics of the problem in the form of two-stage preconditioners. Two-stage preconditioners are based on the idea that coupled system solutions are mainly determined by the solution of their elliptic components (i.e., pressure). Thus, the procedure consists of extracting and accurately solving pressure subsystems. Residuals associated with this solution are corrected with an additional preconditioning step that recovers part of the global information contained in the original system. Optimized and highly complex hierarchical methods such as algebraic multigrid (AMG) offer an efficient alternative for solving linear systems that show a "discretely elliptic" nature. When applicable, the major advantage of AMG is its numerical scalability; that is, the numerical work required to solve a given type of matrix problem grows only linearly with the number of variables. Consequently, interest in incorporating AMG methods as basic linear solvers in industrial oil reservoir simulation codes has been steadily increasing for the solution of pressure blocks. Generally, however, the preconditioner influences the properties of the pressure block to some extent by performing certain algebraic manipulations. Often, the modified pressure blocks are “less favorable” for an efficient treatment by AMG. In this work, we discuss strategies for solving the fully implicit systems that preserve (or generate) the desired ellipticity property required by AMG methods. Additionally, we introduce an iterative coupling scheme as an alternative to fully implicit formulations that is faster and also amenable for AMG implementations. Hence, we demonstrate that our AMG implementation can be applied to efficiently deal with the mixed elliptic-hyperbolic character of these problems. Numerical experiments reveal that the proposed methodology is promising for solving large-scale, complex reservoir problems.

Optical coherence tomographic detection of cells and killing of the same

Abstract: Provided herein are systems, methods and compositions for the use of optical coherence tomography for detection of cells and for killing detected cells.

Low temperature fabrication of discrete silicon-containing substrates and devices

Abstract: Fabrication methods and processes are described, the methods and processes occurring at a low-temperature and involving passivation. The methods and processes easily incorporate annealing, deposition, patterning, lithography, etching, oxidation, epitaxy and chemical mechanical polishing for forming suitable devices, such as diodes and MOSFETs. Such fabrication is a suitable and more cost-effective alternative to a process of diffusion or doping, typical for forming p-n junctions. The process flow does not require temperatures above 700 degrees Centigrade. Formation of p-n junctions in discrete silicon diodes and MOSFETs are also provided, fabricated at low temperatures in the absence of diffusion or doping.

Cation-substituted spinel oxide and oxyfluoride cathodes for lithium ion batteries

Abstract: The present invention includes compositions and methods of making cation-substituted and fluorine-substituted spinel cathode compositions by firing a LiMn2-y-zLiyMzO4 oxide with NH4HF2 at low temperatures of between about 300 and 700°C for 2 to 8 hours and a η of more than 0 and less than about 0.50, mixed two-phase compositions consisting of a spinel cathode and a layered oxide cathode, and coupling them with unmodified or surface modified graphite anodes in lithium ion cells.

The Relations Between Personality and Language Use

Abstract: The authors of this study provided basic descriptive data on the correlation between personality tests and Korean language use. Native Korean-speaking students (N = 80) at Pusan National University completed 2 personality tests, the Myers-Briggs Type Indicator (MBTI; I. B. Myers, M. H. McCaulley, N. L. Quenk, & A. L. Hammer, 1998) and the 5-Factor Inventory (O. P. John, E. M. Donahue, & R. L. Kentle, 1991). They completed a stream-of-consciousness essay, which the authors analyzed using the Korean version of Linguistic Inquiry and Word Count (KLIWC; C. H. Lee, J. Shim, & A. Yoon, 2005). Personality traits were significantly correlated with linguistic variables. Furthermore, the observed correlations between the two types of variables in Korean were consistent with the results of previous LIWC studies conducted in English. The authors discuss language use as a marker of personality.

Cardiopulmonary resuscitation sensor

Abstract: The present invention provides a CPR sensor that includes a thin and substantially flat flexible substrate having one or more sensor arrays, a power source, an output interface and a processor or analog circuit, all of which are disposed on the substantially flat flexible substrate. The substrate can be any shape (e.g., rectangular, circular, a polygon, an irregular shape that is decorative) and made from a polymer, metal film or other suitable material. Note that the substrate can be rigid or semi-flexible instead of flexible. A protective layer may cover the sensor array, the power source, and the processor or analog circuit. Alternatively, a protective covering can be used to encapsulate the device. The one or more sensor arrays measure one or more of the following compressions characteristics: compression depth, compression force, compression frequency and compression acceleration.

Continuous noninvasive glucose monitoring in diabetic, non-diabetic, and critically ill patients with oct

Abstract: New optical coherence tomography (OCT) techniques are disclosed which are designed to improve OCT glucose concentration measure accuracy and are capable of being performed on a continuous basis. New multi-wavelength optical coherence tomography (OCT) techniques are also disclosed and designed to reduce artifacts do to water. New optical coherence tomography (OCT) techniques are also disclosed for determining local profusion rates, local analyte transport rates and tissue analyte transport rates as a measure of tissue health, disease progression and state and tissue transplantation effectiveness.

Compositions and methods for treating a water blocked well

Abstract: The present invention includes a method of treating a hydrocarbon-bearing clastic formation having non-connate water by contacting the hydrocarbon-bearing clastic formation with a composition that includes a solvent and a nonionic fluorinated polymeric surfactant wherein the solvent at least partially displaces or solubilizes the water in the formation.

Detecting tumor biomarker in oral cancer

Abstract: Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma A membrane based cell capture device allows deliver of cell samples and reagents to the membrane

Methods and systems for digital image security

Abstract: Methods and systems for securing digital imagery are provided. In one respect, embedding, compression, encryption, data hiding, and other imaging processing techniques and systems may be provided for digital image security. In one non-limiting example, a method for producing a compressed and encrypted image is provided. An image may be converted into a binary bit stream, and the bit stream may be decomposed into a plurality of segments. A binary sequence based on a first key may be generated and may be used to generate a code matrix. A distance between the code matrix and the distance may be determined for each of the plurality of segments. Using a combined first and second key, a compressed and encrypted image may be obtained.

The role of fenofibrate in clinical practice

Abstract: Clinical guidelines highlight the importance of dyslipidaemia management for reducing the risk of cardiovascular disease in patients with type 2 diabetes and metabolic syndrome. While statins represent the main focus of therapy, there is increasing evidence that the addition of a fibrate such as fenofibrate provides further reduction in risk. Fenofibrate also offers a number of benefits beyond lipid modification; these are mediated by peroxisome proliferator-activated receptor-alpha (PPARα) activation and appear to be independent of effects of glucose and lipid metabolism. Furthermore, as shown by the Fenofibrate Intervention for Event Lowering in Diabetes (FIELD) study, fenofibrate treatment has promising effects in preventing progression of diabetes-related microvascular complications.PPARα is critical to lipid metabolism in the liver. Recent findings which showed that pioglitazone, a PPARγ agonist with weak PPARα activity, improved fatty liver disease in patients with non-alcoholic steatohepatitis (NAS...

Detection and diagnosis of smoking related cancers

Abstract: Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used to stratify smokers into high and low risk groups, as well as determine a patients susceptibility to the development of smoking related cancers.

System, Method and Apparatus for Allocating Resources by Constraint Selection

Abstract: The present invention provides a system, method and apparatus for allocating resources with a linear programming model comprising an objective function and a set of constraints describing feasible allocations of the resources. The method ranks constraints based on a numerical measure derived from criteria selected from at least a first and second group and selects one or more of the top-ranked constraints. A new problem is determined from the model's objective function, the previously selected constraints, and the newly selected constraints, and a tentative resource allocation is determined based on the new problem. Whenever the tentative resource allocation violates a model constraint not in the current problem, one or more of the top-ranked such violated constraints are selected, and the new problem determination and tentative resource allocation steps are repeated. The resources are allocated according to the tentative resource allocation when it does not violate any model constraints.

Gas-containing liposomes

Abstract: The present invention provides gas-containing liposomes In particular, the present invention provide methods of generating gas-containing liposomes where the gas is introduced under pressure, as well as gas-containing liposomes which contain a large volume of gas (eg, 10 ul of gas per 5 mg of gas-containing liposomes) In certain embodiments, the gas-containing liposomes contain nitric oxide gas In some embodiments, such nitric oxide containing liposomes are used to treat a medical condition that is treatable by nitric oxide gas (eg, intimal hyperplasia)