Institution
University of the Philippines Manila
Education•Manila, Philippines•
About: University of the Philippines Manila is a education organization based out in Manila, Philippines. It is known for research contribution in the topics: Population & Medicine. The organization has 2218 authors who have published 2357 publications receiving 88781 citations. The organization is also known as: UPM.
Topics: Population, Medicine, Health care, Public health, Poison control
Papers published on a yearly basis
Papers
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TL;DR: This review will discuss mainly the ER and its role in the pathogenesis and pathophysiology of epidemiologically-relevant diseases, as well as updates on mechanisms related to the ER stress response.
20 citations
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TL;DR: Inhibition of collagen-induced Platelet aggregation by aspirin appears to be optimal at 80–160 mg/day, while ADP-induced platelet aggregation inhibition by aspirin seems to be dose dependent up to 1,300 mg/ day in poststroke patients, albeit to a less remarkable degree at higher doses.
Abstract: Background and Purpose: Aspirin has been shown to reduce the risk of myocardial infarction and stroke. Some investigators believe that low-dose aspirin inhibits platelet aggregation
20 citations
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TL;DR: The main activities and achievements of the RNAS during its first 2 years of existence are described and it is hoped that more interested parties will become involved in the network activities and other international agencies will consider providing technical and financial support to the network in the future.
20 citations
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TL;DR: This work aimed to disentangle sequential neurodegeneration in the striatum of XDP patients, provide evidence for preferential loss of distinct striatal areas in the early phase, and investigate whether iron accumulation is present.
Abstract: Objective X-linked dystonia-parkinsonism (XDP) is a neurodegenerative disease with adult onset dystonia and subsequent parkinsonism. Postmortem and imaging studies revealed remarkable striatal pathology, with a predominant involvement of the striosomal compartment in the early phase. Here, we aimed to disentangle sequential neurodegeneration in the striatum of XDP patients, provide evidence for preferential loss of distinct striatal areas in the early phase, and investigate whether iron accumulation is present. Methods We used multimodal structural magnetic resonance imaging (voxel-based morphometry and relaxometry) in 18 male XDP patients carrying a TAF1 mutation and 19 age-matched male controls. Results Voxel-based relaxometry and morphometry revealed (1) a cluster in the anteromedial putamen showing high iron content and severe atrophy (-55%) and (2) a cluster with reduced relaxation rates as a marker for increased water levels and a lower degree of atrophy (-20%) in the dorsolateral putamen. Iron deposition correlated with the degree of atrophy (ρ = -0.585, p = 0.011) and disease duration (ρ = 0.632, p = 0.005) in the anteromedial putamen. In the dorsolateral putamen, sensorimotor putamen atrophy correlated with disease severity (ρ = -0.649, p = 0.004). Interpretation This multimodal approach identified a patchy pattern of atrophy within the putamen. Atrophy is advanced and associated with iron accumulation in rostral regions of the striatum, whereas neurodegeneration is moderate and still ongoing in dorsolateral areas. Given the short disease duration and predominant dystonic phenotype, these results are well in line with early and preferential degeneration of striosome-rich striatal areas in XDP. ANN NEUROL 2019;86:517-526.
20 citations
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TL;DR: Overall, PTC among Filipino was associated with a more aggressive and recurrent behavior, and FTC among Filipinos appeared to behave similarly with other racial groups.
Abstract: the clinicopathologic profiles, ultrasound features, management received, tumor recurrence, and eventual outcome over a mean follow-up period of 5 years. Results: The mean age at diagnosis was 44±13 years (range, 18 to 82), with a majority of cases occurring in the younger age group (<45 years). Most tumors were between 2 and 4 cm in size. The majority of papillary thyroid cancers (PTCs, 63.2%) and follicular thyroid cancers (FTCs, 54.4%) initially presented as stage 1, with a greater proportion of FTC cases (12.7% vs. 3.7%) presenting with distant metastases. Nodal metastases at presentation were more frequent among patients with PTC (29.9% vs. 7.6%). A majority of cases were treated by complete thyroidectomy, followed by radioactive iodine therapy and thyroid stimulating hormone suppression, resulting in a disease-free state. Excluding patients with distant metastases at presentation, the recurrence rates for papillary and FTC were 30.1% and 18.8%, respectively. Conclusion: Overall, PTC among Filipinos was associated with a more aggressive and recurrent behavior. FTC among Filipinos appeared to behave similarly with other racial groups.
20 citations
Authors
Showing all 2239 results
Name | H-index | Papers | Citations |
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Mitchel S. Berger | 120 | 641 | 53335 |
Baldomero M. Olivera | 92 | 503 | 32064 |
Adrian G. Barnett | 69 | 477 | 16536 |
Martin L. Hibberd | 69 | 247 | 17482 |
Peter Proksch | 69 | 693 | 20980 |
A. Douglas Kinghorn | 64 | 405 | 23180 |
Carl Abelardo T. Antonio | 60 | 106 | 66867 |
Carlos A Castañeda-Orjuela | 58 | 137 | 74960 |
Johannes J. Rasker | 53 | 281 | 9870 |
Paiboon Sithithaworn | 48 | 240 | 8225 |
Antonio L. Dans | 46 | 114 | 15661 |
David R. Hillyard | 46 | 130 | 8296 |
Lorraine S. Evangelista | 44 | 159 | 6001 |
Lourdes J. Cruz | 43 | 58 | 8079 |
Prashant Kapoor | 41 | 415 | 7578 |