Institution
University of the Philippines Manila
Education•Manila, Philippines•
About: University of the Philippines Manila is a education organization based out in Manila, Philippines. It is known for research contribution in the topics: Population & Medicine. The organization has 2218 authors who have published 2357 publications receiving 88781 citations. The organization is also known as: UPM.
Topics: Population, Medicine, Health care, Public health, Poison control
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that the bioavailable fraction of the genotoxic pollutants may pose a threat for both benthic organisms and human health via drinking-water and fish consumption.
Abstract: Laguna Lake, Philippines, is utilised as a resource for drinking and irrigation water and a major source of animal protein for more than 11 million residents. However, it also serves as a huge sink for anthropogenic pollutants from a variety of direct or indirect discharges. Given their well-known properties to accumulate organic pollutants, Lake Laguna sediments have been investigated by use of a newly developed sediment-contact assay to determine the bioavailable fraction of the total genotoxic hazard potential. Freshly fertilized zebrafish eggs (2 h after fertilization) were allowed to develop while exposed to different concentrations of freeze-dried sediments (exposure to bioavailable compounds) as well as organic extracts (complete genotoxic hazard potential including bioaccumulation) prepared from sediments collected at five sites within the lake. Following a 96 h exposure, single-cell suspensions were prepared from macerated larvae and analyzed for DNA strand-breaks by use of the comet assay. Genotoxicity could be identified in both solid-phase exposure scenarios as well as after exposure to organic sediment extracts. Only the South Bay (SB) site did not show a significant genotoxic burden relative to controls in tests of both freeze-dried sediment and organic extracts. In contrast, the Northwest Bay site displayed pronounced genotoxicity to the zebrafish embryos in both exposure scenarios. Perylene and copper in the sediments could be identified as potential causes of the genotoxic response. To compare the results (maximum induction coefficients) of zebrafish embryos with an established comet protocol, rainbow trout liver cells (RTL-W1) were exposed to the same extracts. The findings correlated well (Spearman correlation r = 0.90), proving a good reliability of the results from zebrafish primary cells. In conclusion, the present study demonstrates that the bioavailable fraction of the genotoxic pollutants may pose a threat for both benthic organisms and human health via drinking-water and fish consumption.
99 citations
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TL;DR: SPECT/CT detected more SNs and changed the drainage territory, leading to surgical adjustments in a considerable number of patients in all malignancies studied but especially in the pelvic cancer group because of this group's deep lymphatic drainage.
Abstract: We aimed to assess the additional value of SPECT/CT over planar lymphoscintigraphy (PI) in sentinel node (SN) detection in malignancies with different lymphatic drainage such as breast cancer, melanoma, and pelvic tumors. Methods: From 2010 to 2013, 1,508 patients were recruited in a multicenter study: 1,182 breast cancer, 262 melanoma, and 64 pelvic malignancies (prostate, cervix, penis, vulva). PI was followed by SPECT/CT 1–3 h after injection of 99mTc-colloid particles. Surgery was performed the same or next day. Results: Significantly more SNs were detected by SPECT/CT for breast cancer (2,165 vs. 1,892), melanoma (602 vs. 532), and pelvic cancer (195 vs. 138), all P
97 citations
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TL;DR: In this report, the probiotic potential of Lactobacillus mucosae LM1 is characterized, focusing on its in vitro mucin‐adhesion abilities.
Abstract: Aims
In this report, we characterized the probiotic potential of Lactobacillus mucosae LM1, focusing on its in vitro mucin-adhesion abilities.
Methods and Results
Screening assays were used to evaluate LM1. Previous studies on Lact. mucosae species have been performed, but few have examined the ability of this species to adhere to and colonize the intestinal mucosa. Thus, adhesion, aggregation and pathogen inhibition assays of LM1 along with microbial adhesion to solvents (MATS) assay were carried out in comparison with another putative probiotic, Lactobacillus johnsonii PF01, and the commercial strain, Lactobacillus rhamnosus GG. Based on MATS assay, the cell surfaces of the lactobacilli strains were found to be hydrophobic and highly electron-donating, but the average hydropathy (GRAVY) index of predicted surface-exposed proteins in the LM1 genome indicated that most were hydrophilic. LM1 showed the highest adhesion, aggregation and hydrophobicity among the strains tested and significantly inhibited the adhesion of Escherichia coli K88 and Salmonella enterica serovar Typhimurium KCCM 40253. Correlations among adhesion, aggregation and hydrophobicity, as well as between coaggregation and displacement of E. coli, were observed.
Conclusions
Increased adhesion may not always correlate with increased pathogen inhibition due to various strain-specific mechanisms. Nevertheless, LM1 has promising probiotic properties that can be explored further using a genomics approach.
Significance and Impact of the Study
Our data on adhesion of LM1 strain showed a significant correlation between adhesion, hydrophobicity of cell surface and autoaggregation. This study gives basic knowledge for the elucidation of the adhesion mechanism of Lactobacillus sp. and prediction of its adherence in specific host models.
97 citations
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University of Zurich1, Royal Botanic Gardens2, Naturalis3, University of Michigan4, University of Göttingen5, Royal Botanic Garden Edinburgh6, Aarhus University7, University of Vermont8, Boise State University9, University of Sydney10, University of Minnesota11, Chinese Academy of Sciences12, Papua New Guinea University of Technology13, Federal University of Mato Grosso do Sul14, Missouri Botanical Garden15, Forest Research Institute16, Forest Research Institute Malaysia17, Natural History Museum18, University of Bonn19, Martin Luther University of Halle-Wittenberg20, National Parks Board21, University of Aberdeen22, University of the Philippines Manila23, Kyoto University24, Sao Paulo State University25, University of Melbourne26, Queen's University Belfast27, University of Oxford28, University of North Carolina at Wilmington29, Museum of New Zealand Te Papa Tongarewa30, Western Michigan University31, New Mexico State University32, Universidade Federal de Viçosa33, Colorado State University34, Trinity College, Dublin35, University of Florida36, University of Western Australia37, Commonwealth Scientific and Industrial Research Organisation38, University of Glasgow39, Leiden University40
TL;DR: A catalogue of the vascular flora of New Guinea indicates that this island is the most floristically diverse in the world, and that 68% of the species identified are endemic to New Guinea.
Abstract: New Guinea is the world’s largest tropical island and has fascinated naturalists for centuries1,2. Home to some of the best-preserved ecosystems on the planet3 and to intact ecological gradients—from mangroves to tropical alpine grasslands—that are unmatched in the Asia-Pacific region4,5, it is a globally recognized centre of biological and cultural diversity6,7. So far, however, there has been no attempt to critically catalogue the entire vascular plant diversity of New Guinea. Here we present the first, to our knowledge, expert-verified checklist of the vascular plants of mainland New Guinea and surrounding islands. Our publicly available checklist includes 13,634 species (68% endemic), 1,742 genera and 264 families—suggesting that New Guinea is the most floristically diverse island in the world. Expert knowledge is essential for building checklists in the digital era: reliance on online taxonomic resources alone would have inflated species counts by 22%. Species discovery shows no sign of levelling off, and we discuss steps to accelerate botanical research in the ‘Last Unknown’8. A catalogue of the vascular flora of New Guinea indicates that this island is the most floristically diverse in the world, and that 68% of the species identified are endemic to New Guinea.
96 citations
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TL;DR: In this article, the efficacy of povidone-iodine as a treatment for conjunctivitis in pediatric patients was reported and the main outcome measures were days until cured and proportion cured after 1 and 2 weeks of treatment.
96 citations
Authors
Showing all 2239 results
Name | H-index | Papers | Citations |
---|---|---|---|
Mitchel S. Berger | 120 | 641 | 53335 |
Baldomero M. Olivera | 92 | 503 | 32064 |
Adrian G. Barnett | 69 | 477 | 16536 |
Martin L. Hibberd | 69 | 247 | 17482 |
Peter Proksch | 69 | 693 | 20980 |
A. Douglas Kinghorn | 64 | 405 | 23180 |
Carl Abelardo T. Antonio | 60 | 106 | 66867 |
Carlos A Castañeda-Orjuela | 58 | 137 | 74960 |
Johannes J. Rasker | 53 | 281 | 9870 |
Paiboon Sithithaworn | 48 | 240 | 8225 |
Antonio L. Dans | 46 | 114 | 15661 |
David R. Hillyard | 46 | 130 | 8296 |
Lorraine S. Evangelista | 44 | 159 | 6001 |
Lourdes J. Cruz | 43 | 58 | 8079 |
Prashant Kapoor | 41 | 415 | 7578 |