University of the Philippines Manila

About: University of the Philippines Manila is a education organization based out in Manila, Philippines. It is known for research contribution in the topics: Population & Medicine. The organization has 2218 authors who have published 2357 publications receiving 88781 citations. The organization is also known as: UPM.

Adaptation and foraging from the Terminal Pleistocene to the Early Holocene: Excavation at Bubog on Ilin Island, Philippines

Abstract: The recently discovered human remains from Callao Cave, northern Luzon, Philippines securely date the migration of hominins into the Philippines to ca. 70 kya (thousands of years ago). The direct route to reach Luzon from the Asian mainland is via Borneo, Palawan, through Mindoro and into Luzon. Our research focuses on Mindoro Island as a potential stepping stone to the main Philippine Archipelago. While Palawan and Luzon have produced evidence for early human occupation, no systematic research on the prehistory of Mindoro has been conducted until now. We report on recent archaeological investigations at the Bubog rockshelter sites on the small island of Ilin just off the coast of Mindoro. The excavations produced evidence of stratified sequences of human habitation at the two rockshelter sites in the form of dense shell middens that date to ca. 11 kya onwards. They provide direct evidence on how variability in landscape formation, sea levels, and landmass during the terminal Pleistocene and early...

Three-year Efficacy and Safety of Takeda’s Dengue Vaccine Candidate (TAK-003)

Abstract: 1Hospital Maternidad Nuestra Senora de Altagracia, Santo Domingo, Dominican Republic; 2Takeda Vaccines, Inc., Boston, Massachusetts, USA; 3Hospital del Nino Dr. Jose Renan Esquivel, Sistema Nacional de Investigacion at SENACYT, Centro de Vacunacion Internacional (Cevaxin), Panama City, Panama; 4Centro de Atencion e Investigacion Medica, CAIMED, Bogota, Colombia; 5Centro de Estudios en Infectologia Pediatrica, Universidad del Valle and Centro Medico Imbanaco, Cali, Colombia; 6Research Institute For Tropical Medicine, Muntinlupa, Philippines; 7University of the Philippines Manila, Ermita, Philippines; 8Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; 9Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 10CAIMED, Dominicana, Santo Domingo, Dominican Republic; 11De La Salle Medical and Health Sciences Institute, Dasmarinas, Philippines; 12Phramongkutklao Hospital, Bangkok, Thailand; 13National Autonomous University of Nicaragua, Leon, Nicaragua; 14Nucleo de Doencas Infecciosas, Centro de Ciencias da Saude-UFES, Vitoria, Brazil; 15Centre for Clinical Management of Dengue & Dengue Haemorrhagic Fever, Negombo General Hospital, Negombo, Sri Lanka; 16University of Colombo, Colombo, Sri Lanka; 17Associacao Obras Sociais Irma Dulce Hospital Santo Antonio and Oswaldo Cruz Foundation, Bahia, Brazil; 18Faculty of Medicine, University of Kelaniya, Colombo, Sri Lanka; 19Faculty of Medical Sciences, University of Sri Jayawardenenpura, Colombo, Sri Lanka; 20Instituto de Medicina Tropical da Universidade Federal do Rio Grande do Norte, Natal, Brazil; 21Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil; 22Takeda Pharmaceuticals International AG, Zurich, Switzerland; and 23Philippines-Armed Forces Research Institute of Medical Sciences Virology Research Unit, Cebu City, Philippines

Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix

Abstract: Germline mutations of the gene encoding human fibroblast growth factor receptor 3 (FGFR3) have been shown to be responsible for several related autosomal dominant forms of syndromic craniosynostosis and short limb dwarfism. Somatic activating mutations of FGFR3 were recently reported to occur in three of 12 (25%) uterine cervical carcinomas and nine of 26 (35%) bladder carcinomas, suggesting that constitutive activation of FGFR3 may be an important mechanism underlying the development and/or progression of these common epithelial malignancies. In order to investigate further a possible role for FGFR3 mutations in cervical carcinogenesis, we performed sequence-based mutational analysis of FGFR3 in 51 primary cervical carcinomas and seven cervical carcinoma-derived cell lines. The regions analysed (exons 7, 10, 13, 15, and 19) encompassed all previously described FGFR3 mutations. A single nucleotide substitution at codon 249, predicting a serine to cysteine amino acid substitution (S249C) in the FGFR3 extracellular domain, was identified in one primary tumor. Only wild type FGFR3 alleles were identified in the remaining tumors and cell lines. The S249C mutation is the only FGFR3 mutation described to date in cervical carcinomas. These findings suggest that while activating mutations of FGFR3 occur in cervical cancer, they may not be as common as initially reported.