Women's College, Kolkata

About: Women's College, Kolkata is a based out in . It is known for research contribution in the topics: Population & Breast cancer. The organization has 4552 authors who have published 5906 publications receiving 178809 citations.

Sex-specific T-cell regulation of angiotensin II-dependent hypertension.

Abstract: Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II-induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1-deficient (Rag1(-/-)) mice. Sex differences in peak mean arterial pressure in wild-type were lost in Rag1(-/-) mice (mm Hg: wild-type-F, 136±4.9 versus wild-type-M, 153±1.7; P<0.02; Rag1(-/-)-F, 135±2.1 versus Rag1(-/-)-M, 141±3.8). Peak mean arterial pressure was 13 mm Hg higher after adoptive transfer of male (CD3(M)→Rag1(-/-)-M) versus female (CD3(F)→Rag1(-/-)-M) T cells. CD3(M)→Rag1(-/-)-M mice exhibited higher splenic frequencies of proinflammatory interleukin-17A (2.4-fold) and tumor necrosis factor-α (2.2-fold)-producing T cells and lower plasma levels (13-fold) and renal mRNA expression (2.4-fold) of interleukin-10, whereas CD3(F)→Rag1(-/-)-M mice displayed a higher activation state in general and T-helper-1-biased renal inflammation. Greater T-cell infiltration into perivascular adipose tissue and kidney associated with increased pressor responses to angiotensin II if the T cell donor was male but not female and these sex differences in T-cell subset expansion and tissue infiltration were maintained for 7 to 8 weeks within the male host. Thus, the adaptive immune response and role of pro- and anti-inflammatory cytokine signaling in hypertension are distinct between the sexes and need to be understood to improve therapeutics for hypertension-associated disease in both men and women.

Gender differences in the symptoms of major depressive disorder.

Abstract: Data from the Canadian Community Health Survey 1.2 were used for a gender analysis of individual symptoms and overall rates of depression in the preceding 12 months. Major depressive disorder was assessed using the Composite International Diagnostic Interview in this national, cross-sectional survey. The female to male ratio of major depressive disorder prevalence was 1.64:1, with n = 1766 having experienced depression (men 668, women 1098). Women reported statistically more depressive symptoms than men (p < 0.001). Depressed women were more likely to report "increased appetite" (15.5% vs. 10.7%), being "often in tears" (82.6% vs. 44.0%), "loss of interest" (86.9% vs. 81.1%), and "thoughts of death" (70.3% vs. 63.4%). No significant gender differences were found for the remaining symptoms. The data are interpreted against women's greater tendency to cry and to restrict food intake when not depressed. The question is raised whether these items preferentially bias assessment of gender differences in depression, particularly in nonclinic samples.

Spatial prediction of COVID-19 epidemic using ARIMA techniques in India.

Abstract: The latest Coronavirus (COVID-19) has become an infectious disease that causes millions of people to infect. Effective short-term prediction models are designed to estimate the number of possible events. The data obtained from 30th January to 26 April, 2020 and from 27th April 2020 to 11th May 2020 as modelling and forecasting samples, respectively. Spatial distribution of disease risk analysis is carried out using weighted overlay analysis in GIS platform. The epidemiologic pattern in the prevalence and incidence of COVID-2019 is forecasted with the Autoregressive Integrated Moving Average (ARIMA). We assessed cumulative confirmation cases COVID-19 in Indian states with a high daily incidence in the task of time-series forecasting. Such efficiency metrics such as an index of increasing results, mean absolute error (MAE), and a root mean square error (RMSE) are the out-of-samples for the prediction precision of model. Results shows west and south of Indian district are highly vulnerable for COVID-2019. The accuracy of ARIMA models in forecasting future epidemic of COVID-2019 proved the effectiveness in epidemiological surveillance. For more in-depth studies, our analysis may serve as a guide for understanding risk attitudes and social media interactions across countries.

Complementary and alternative medicine use is associated with an increased perception of breast cancer risk and death.

Abstract: Purpose Complementary and alternative medicines (CAMS) are frequently used by patients with breast cancer and their use may be related to the presence of psychosocial distress The objective of this study is to assess the presence of anxiety and depression in breast cancer patients who use CAM and assess how they perceive their risks of recurrence and dying from breast cancer compared to non-users Methods Breast cancer patients attending ambulatory clinics at a single cancer center were approached by their oncologist Participants completed a self-administered survey regarding CAM usage, beliefs associated with CAM, views of their risks of developing recurrent cancer, and of dying of breast cancer The presence of anxiety and depression was scored using the Hospital Anxiety and Depression Scale (HADS) Responses were scored and compared between CAM users and non-users Results A total of 251 patients completed the survey CAM usage was reported by 43% of patients Individuals who used CAM were younger [531 versus 630 year (p < 0001)], had higher education (p < 0001), were more likely to have full time employment [257 versus 163% (p < 0001)] and have private insurance for medications (76 versus 60%, p=0007) compared to non-users CAM users perceived their risk of recurrence (p = 0011) and death from breast cancer (p=00001) as being significantly greater than non-users There were no significant differences in anxiety or depression scores between CAM and non-users Conclusion CAM use is associated with an increased perception of breast cancer recurrence and of breast cancer-related death There was no association between the presence of anxiety or depression and CAM use Improved patient understanding of actual risks of recurrence and death are required such that women will be able to make more informed decisions about using CAMs