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TL;DR: Despite near complete loss of diaphragm strength in advanced Duchenne muscular dystrophy, diaphagm electrical activation measured with an esophageal electrode array remains clearly detectable in all but one patient.
49 citations
TL;DR: In this article, a simple aerosol dynamics model is employed to understand the temporal evolution of the aerosol size distribution during dust and precipitation events, and the model predicted and observed size distributions are compared with the measured data.
49 citations
TL;DR: A role for PTEN in breast tumorigenesis in an in vivo model is indicated from studies showing that germline PTEN mutation in Cowden disease predisposes to breast cancer, the frequent loss of heterozygosity at the PTEN locus, and reduced PTEN protein levels in sporadic breast cancers.
Abstract: The PTEN gene is often mutated in primary human tumors and cell lines, but the low rate of somatic PTEN mutation in human breast cancer has led to debate over the role of this tumor suppressor in this disease. The involvement of PTEN in human mammary oncogenesis has been implicated from studies showing that germline PTEN mutation in Cowden disease predisposes to breast cancer, the frequent loss of heterozygosity at the PTEN locus, and reduced PTEN protein levels in sporadic breast cancers. To assay the potential contribution of PTEN loss in breast tumor promotion, Li et al. [1] crossed Pten heterozygous mice with mouse mammary tumor virus-Wnt-1 transgenic (Wnt-1 TG, Pten+/-) mice. Mammary ductal carcinoma developed earlier in Wnt-1 TG, Pten+/- mice than in mice bearing either genetic change alone, and showed frequent loss of the remaining wild-type PTEN allele. These data indicate a role for PTEN in breast tumorigenesis in an in vivo model.
49 citations
TL;DR: The results suggest that CYP1A2 activity is correlated with hormones, blood lipids, and lifestyle factors associated with breast cancer risk, although some of the observed associations were contrary to hypothesized directions.
Abstract: Introduction
Breast cancer risk may be determined by various genetic, metabolic, and lifestyle factors that alter sex hormone metabolism. Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.
49 citations
Journal Article•
TL;DR: It is questioned the value of uncritically continuing to collect medical forensic evidence in sexual assault cases, as neither the collection of sperm, semen and/or saliva nor the documentation of clinically observed injuries was significant in predicting an arrest and charge.
Abstract: Very little is known about the role of medical evidence in the legal resolution of sexual assault cases. A retrospective review of hospital and police records was conducted to determine whether medico-legal evidence was related to the police laying of charges. Data were obtained from 187 female sexual assault victims who presented to a large urban hospital-based sexual assault treatment center and the police in Ontario, Canada between January 1 and December 31, 1994. Using stepwise logistic regression medico-legal variables were tested while controlling for non-medical factors. Neither the collection of sperm, semen and/or saliva nor the documentation of clinically observed injuries was significant in predicting an arrest and charge. In contrast, non-medical variables such as the victim's age, use of alcohol, resistance and relationship to the assailant, and the corroborating evidence of a witness were related to charge-laying. We question the value of uncritically continuing to collect medical forensic evidence. Language: en
49 citations
Authors
Showing all 4552 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Paul G. Richardson | 183 | 1533 | 155912 |
| Steven A. Narod | 134 | 970 | 84638 |
| Peter C. Austin | 112 | 657 | 60156 |
| Sandra E. Black | 104 | 681 | 51755 |
| Michael B. Yaffe | 102 | 379 | 41663 |
| Jeffrey S. Ginsberg | 101 | 343 | 37014 |
| Robert S. Kerbel | 101 | 360 | 43411 |
| Kathleen I. Pritchard | 96 | 534 | 55670 |
| Aditya K. Gupta | 86 | 695 | 26368 |
| Soo-Jin Park | 86 | 1282 | 37204 |
| Amiram Gafni | 85 | 575 | 31319 |
| Hiroo Imura | 83 | 781 | 29276 |
| Muhammad Mamdani | 83 | 441 | 28319 |
| Gillian A. Hawker | 82 | 309 | 35570 |
| Andrew R. Willan | 80 | 346 | 30215 |