Showing papers in "Blood in 1963"

TL;DR: The study was stopped after analysis of the remission times of 21 pairs of patients, since patients maintained on placebo were treated with 6-MP when relapse occurred, and overall survival was not significantly different for the two treatment programs.

TL;DR: It is suggested that the Ph1 chromosome usually arises in a precursor cell common to the erythroid, granulocytic, and megakaryocytic cells, but not the lymphoid series of hemopoietic cells.

TL;DR: Radioautographic studies provide evidence to support a concept of the mechanism whereby the small intestine controls absorption of iron, postulated that with iron excess the iron-receptor mechanism in these cells is saturated with intrinsic iron; this then prevents the cell from accepting dietary iron.

TL;DR: The data summarized are compatible with the hypothesis that function of the loci of the β and δ chains of globin is wholly suppressed, quite possibly by a mutant "operator" gene affecting linked structural loci.

TL;DR: Human maternal whole blood was treated with Atabrine in vitro, and the cellular portion returned to the maternal circulation within 15 hours of the time of delivery in nine cases, suggesting human transplacental passage, from mother to fetus, of small numbers of leukocytes and platelets.

TL;DR: It may well be that AHG and proaccelerin must be activated by minute traces of thrombin before they can participate effectively in the generation of intrinsic prothrombinase activity.

TL;DR: The occurrence of diseases of this group among patients with this immunologic defect appears to be a greater-than-chance association and possible reasons for the association are discussed.

TL;DR: Large, usually single inclusions, having the staining properties of Heinz-bodies and occurring spontaneously in thalassemic cells, are described and it is concluded that these inclusions represent precipitated hemoglobin, very likely uncombined α-chains.

TL;DR: The large cells have ample cytoplasm with multivesicular bodies, well-developed Golgi apparatus, scanty endoplasmic reticulum, ample ribosomes, and variable fat-laden vacuoles as well as peculiar granular inclusions, large and occasionally bizarre nuclei with prominent nucleoli.

TL;DR: In this hypothetical model of intestinal function the ferritin apparatus of the absorptive epithelial cells provides the most important mechanism for day-to-day control of iron balance.

TL;DR: Vincristine produces tumor regression in the majority of the patients with lymphoma where its activity compares favorably with that of the alkylating agents and vinblastine.

TL;DR: In this paper, various aspects of gastrointestinal absorption of iron salts were studied in normal, iron-loaded, and iron-deficient rats using Fe59 and whole body counting, and the results showed that the intestine may take up more iron than is ultimately transferred to plasma.

TL;DR: Cytosine arabinoside induced objective, but temporary, decrease of tumor masses in three patients with lymphosarcoma and slight decrease in some lesions in two out of ten treated patients with disseminated carcinomatosis.

TL;DR: Mean diaphorase values of smaller infants was less than that of larger infants, suggesting a greater degree of metabolic immaturity in the former group, even in the absence of prematurity.

TL;DR: The hypothesis that leukocyte alkaline phosphatase formation is controlled by a gene on chromosome number 21—the chromosome for which mongolian idiots are trisomic was interpreted as confirming (but not proving) the hypothesis.

TL;DR: This study of 17 cases further establishes acute promyelocytic leukemia with hypofibrinogenemia as a distinct entity that has a rapid course characterized by severe hemorrhagic manifestations and a poor response to therapy.

TL;DR: The investigation of 60 "pan-agglutinating, unspecific" eluates has disclosed distinct blood group specificity within the rhesus system in at least 70 per cent, increasing confidence in their true antibody nature.

TL;DR: Findings are compatible with the view that the bone marrow eosinophil is the site of profibrinolysin synthesis and may be interpreted as indicating a role of the eos inophil in clot lysis and in maintaining the fluidity of the blood.

TL;DR: The occurrence of abnormal bodies in the cytoplasm of neutrophils, eosinophils, monocytes and lymphocytes of Aleutian mink is reported and similarities of these bodies to the leukocyte abnormalities of Chediak-Higashi syndrome of children are pointed out.

TL;DR: Evidence is presented that the inclusions are true nuclear inclusion bodies, that they represent nuclear elaboration of glycoprotein, and that they may be found in all three immunoelectrophoretic varieties of multiple myeloma, as well as in macroglobulinemia.

TL;DR: The use of surface scanning showed that patients with significant splenic localization were more suitable candidates for splenectomy that those without this localization.

TL;DR: The accumulation of arrested metaphases in the normal bone marrow and in leukemic cells of the animals treated with vincristine followed a pattern similar to the one observed after treatment with colchicine or vincaleukoblastine (vinblastine).

TL;DR: It was clear that γ, β2A, γ1M, and Bence Jones proteins were not associated exclusively with a single morphologic form of malignant cell, but the variety of immunofluorescent positive cells in each patient was more restricted than in a group of patients with a specific protein abnormality.

TL;DR: In this article, it has been shown that mixtures of normal and G-6-PD deficient nitrite-treated erythrocytes reduced methemoglobin at a rate considerably more rapid than that computed from their individual rates of reduction.

TL;DR: The partial purification of glutathione reductase by a combination of salting out, heating and chromatographic procedures is described and no appreciable change in the ratio of activity of the enzyme with DPN and TPN as a coenzyme has been found.

TL;DR: Lymphocytes from the peripheral blood of a patient with chronic lymphocytic leukemia were isolated and subjected to electron microscopy and aggregates of virus-like particles observed as organized structures in the cytoplasm of the cells.

TL;DR: An activated form of PTC (PTC') which incorporates the properties of both native PTC and activated PTA (PTA') has been identified in BaSO4 eluates of intact citrated plasma.

TL;DR: Reutilization of iron in patients with anemia complicating malignancy disease has shown a significant decrease which correlates well with the severity of the anemia.

TL;DR: It seemed likely that therapy depressed the number of abnormal (Ph1-positive) mitoses in patients in relapse, but there was, however, no evidence that these ever disappeared from the marrow, even in complete remission.