Showing papers in "Chemistry and Physics of Lipids in 1984"

TL;DR: The sphingolipids prepared by this method can be used to study metabolism, enzymology and physicochemical properties of D-erythro well defined simple sphingosine base composition.

TL;DR: In this article, structural analysis, a purification scheme and stability information on a fluorescent cholesterol analogue, which has been used as a probe in several model and biological systems, are presented.

TL;DR: In this paper, the authors have shown that at all spacings van der Waals attraction is overwhelmed by hydration and undulation forces, and that thin-walled tubes grow from the Lα phase into the free water.

TL;DR: In this paper, the phase behavior of multilamellar dispersions of 1-O-(1′-alkenyl)-2-oleoyl-glycerophosphoethanolamine (ETHanolamine plasmalogen), 1 O(1)-alkyl-2.2.5.

TL;DR: The results suggest that different drug release processes are occurring in buffer and in serum, with the rate of drug release much faster in serum than in buffer.

TL;DR: The conformation and molecular packing of monosodium 1,2-dimyristoyl-sn-glycerophosphate (DMPA) has been determined by single crystal analysis.

TL;DR: In this paper, 2H-NMR measurements of the ordering of several n-alkane and one n-alcohol solutes in lipid bilayers formed from DML are reported.

TL;DR: The data show that at the molar concentration usually employed in biological studies with these compounds, one can assume that they will be present as monomolecular species, and it seems unlikely that the widely diverse biological activities of these compounds can be explained by this physical parameter.

TL;DR: In this article, the phase behavior of cerebroside sulfate (CBS) was investigated in the presence of a number of mono-and divalent cations and showed that the sensitivity of the transition temperature to cation concentration reflects increased participation of the lipid in intermolecular hydrogen bonding interactions as the negative charge of the sulfate is shielded.

TL;DR: In this article, a heterolytic mechanism for acid catalysis was indicated, even though most of the products characterized also have been observed as a result of homolytic decomposition of the hydroperoxide via an oxy radical.

TL;DR: In this article, the structure of the L2-phase of monoglycerides has been studied by freeze-fracture electron microscopy and it has been shown that these structures are consistent with X-ray studies indicating curved lipid bilayers arranged in parallel, separating similarly curved aqueous layers of finite size, forming a higly dynamic structure of a medium-range order.

TL;DR: The results obtained show that the percentage of the total area occupied by the protein at the interface is an important parameter leading to lateral phase separations; the amount and area contribution of the protein accepted in the film before the components become immiscible increase with the complexity of the polar head group of the glycosphingolipids.

TL;DR: It is shown that hemin intercalates into the membrane and increases its surface pressure, depending on the lipid composition and the initial surface pressure: negative surface charges and particularly looser compaction of the phospholipids reduce the effect of hemin.

TL;DR: The results revealed characteristic differences between cardiac and hepatic FABPs with regard to binding a fatty acid.

TL;DR: The break point observed on fatty acid isotherms corresponds to a transition between two two-dimensional phases, since it is clearly distinct from the collapse as mentioned in this paper. But the transformation from the liquid expanded phase to the liquid condensed phase is slow and relaxations with characteristic times have been observed.

TL;DR: Although C16PC and C17PC individually develop subtransitions, an equimolar mixture does not, and mixtures of C14/C16PC containing 10 or more mol% of C 14PC do display a subtransition, these results underscore the primary dependence of subtrans Transition formation in phosphatidylcholine dispersions on acyl chain structure.

TL;DR: It has been shown by electron spin resonance (ESR) spectroscopy and simulation of the first derivative ESR spectra that the radicals formed by this method are the already known tocopheroxyl radicals.

TL;DR: The thermotropic behavior of mixtures of cholesterol with phosphatidylserine (PS) or galactocerebroside was investigated in this paper, and at low cholesterol concentrations only one peak in the thermograms was obtained, at about Xchol = 0.3 another peak at higher temperatures was also seen, this peak stems from phase transition of almost pure cholesterol phase.

TL;DR: In this paper, the activation energy for conduction was measured as 35 ± 2 kJ/mol, which is extremely unlikely that ions pass directly through the hydrophobic interior.

TL;DR: In this paper, the complex dielectric spectrum of sonicated aqueous solutions of purified dimyristoylphosphatidylcholine has been measured as a function of frequency between 3 kHz and 40 GHz.

TL;DR: The synthetic scheme developed in this study utilizes commercial cholesterol as the starting material and provides a simplified method for the preparation of 4,4'-dimethyl-7-oxygenated steroids.

TL;DR: A remarkable dissociating influence of serotonin on ganglioside-Ca2+ and phosphatidylserine- Ca2+ complexes is observed and the possible functional role of phospholipids andgangliosides in vivo is discussed with regard to the specific Ca2-binding properties of these lipids.

TL;DR: In this article, multicomponent self-diffusion data on dioleoyl (DOL)- and dipalmitoyllecithin (DPL) vesicle-water systems have been determined using a Fourier transform NMR technique.

TL;DR: In this paper, the spin trapping of peroxy and alkoxy radicals generated from the hydroperoxide of methyl linoleate was studied using methyl-N -duryl nitrone (MDN) and phenyl- N -tert-butyl nitrone(PBN) as spin traps.

TL;DR: Hydrogenation of the azidophospholipid gave 2-amino-2-deoxy-1-O-hexadecyl-sn-glycero-3-phosphorylcholine which is a versatile intermediate for the preparation of amide analogs of platelet-activating factor and related derivatives.

TL;DR: The dioleoyl phosphatidylethanolamine ([C11-2H2]DOPE) shows similar bilayer to hexagonal (H11) transition characteristics as unlabelled DOPE, and this transition can be conveniently monitored by 2H-NMR techniques.

TL;DR: In this paper, rotamer populations around bonds in the polar headgroups were calculated from the 1.400 MHz 1 H-resonances of 1-phosphatidyl-myoinositol (PI), DPI, and TPI in CD 3 OD.

TL;DR: Aqueous dispersions of dimyristoyl phosphatidylcholine (DMPC) mixed with 1-palmitoyl-2-oleoyl (POPC) or with 1Palmitoyyl-2stearoyl(PSPC) have been studied by differential scanning calorimetry as mentioned in this paper.

TL;DR: In this article, the usefulness of dimethylphosphoryl chloride, a simple phosphorylating agent, for the synthesis of phospholipids is illustrated by the synthesis 1-palmitoyl-2-O-hexadecyl-rac-glycero-3-phosphocholine.

TL;DR: Direct measurements of the partitioning of phenol in the phospholipid vesicles confirm these results and show a limited and concentration-dependent solubility.