Showing papers in "Experimental and Molecular Pathology in 1981"

TL;DR: In vitro studies suggest that angiotensin II and vasopressin, by modulating both number and size of arterial smooth muscle cells, may play a direct and until now unexpected role in the development of chronic vascular disease in man.

TL;DR: The amount of increase in lumen area that was due to growth of the coronary arteries and that due to change in intimal lesions was determined and was dependent both on the size of plaques and time.

TL;DR: Consumption of allcoholic beverages does not increase aortic and liver lipid deposition and affords some protection from development of atherosclerosis in this animal model.

TL;DR: The data appear to indicate that the polymorphonuclear leukocytes infiltrated into the kidney plays a role in renal tissue destruction in the early phase of E. coli -induced acute pyelonephritis.

TL;DR: In situ conversion of inorganic arsenic to methylated metabolites represents a detoxication pathway for both the dam and the developing embryo and suggests that arsenic-induced damage to the paraxial mesoderm may be related to the ultimate skeletal malformations.

TL;DR: In this paper, the effect of polyhydroxy metabolites of benzene with particularly reactive SH groups on microtubules may explain their sub-lethal effects of lymphocyte function, suggesting an important interaction of the metabolites with intracellular SH groups critical to early events in blastogenesis.

TL;DR: It is concluded that at least one mechanism of hemoglobin-iron absorption involves endocytosis and degradation ofhemoglobin in membrane-bound organelles with subsequent conversion of its iron to an inorganic form, which is then transported to the lateral intercellular space where subsequent processing is similar to that observed for absorbed inorganic iron.

TL;DR: Wistar rats were given drinking water containing 200 ppm CdCl 2 for 4 to 91 weeks and the kidneys and femoral bones were examined morphologically, showing degenerative changes in the proximal convoluted tubules.

TL;DR: In this paper, the identity of these collagen types was established by stained protein band patterns on sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis.

TL;DR: Data indicate that monocytes selectively adhere to defective endothelium, and that the adhesion is in part mediated via the Fc receptor, and the significance of intimal monocytes for arterial repair and atherogenesis is discussed.

TL;DR: Results clearly demonstrated that exposure to 0.5 ppm ozone for 180 days resulted in a persistent inflammatory response in the pulmonary centriacinar region together with a structural modification of the terminal bronchiole—proximal alveolar duct junction.

TL;DR: It is suggested that CBLT in experimentally diabetic rats is associated with the altered metabolic state in these animals and fail to reveal morphologic evidence of an intrinsic diabetic cardiomyopathy and suggest that the extent of capillary basal laminar thickening in diabetic rats in particular is relatable to the length of exposure to the hyperglycemia.

TL;DR: The in vivo photocatabolities isolated from urine of jaundiced neonates are nontoxic to erythrocyte membrane, suggesting similarity between in vivo and in vitro mechanisms of cytotoxicity mediated by the bile pigment.

TL;DR: It was concluded that concentrations of O 2 at 61% and higher inhibit reparative cell division in O 3 -damaged alveoli of mice.

TL;DR: In vitro studies with trout liver microsomes showed that control trout liver was capable of producing the toxic pyrrole metabolites at a rate comparable to uninduced rat livermicrosomes.

TL;DR: The subcellular localization and quantitatively low levels of PAA and other serine proteases found in human arterial and venous cells may reflect the presence of membrane-associated enzymes whose biological role is restricted to local homeostasis.

TL;DR: The results suggest that cellular autophagy may play an important role in the accommodation of chemically induced alterations in hepatocytes by preferentially sequestering chloroquine, as well as restoring cellular ultrastructure.

TL;DR: The results obtained demonstrate that the antispermatogenic agents induce, both in vivo and in vitro, similar changes in energy metabolism; respiration, RCR, and ADP affinity are significantly reduced, while aerobic glycolysis is increased.

TL;DR: Cysteamine-induced adrenocortical necrosis was significantly suppressed by medullectomy, hypophysectomy, treatment with aminoglutethimide, and somatostatin, while it was moderately reduced by phenoxybenzamine, labetatol, and metyrapone.

TL;DR: Differences in vascular perfusion within and surrounding the site of burn and freeze injury are described and it is suspected that factors released from the burned matrix account for some of these differences in pattern of vascular perfusions.

TL;DR: The inhibition of elastin formation by β-aminopropionitrile was associated with: apposition ofElastin on the old fiber in the form of button-like appendices, absence of microfibrils around this abnormally deposited elASTin, and increase of proteoglycan content.

TL;DR: The findings indicate that tissue angiotensin-converting enzyme may be used as a marker of granulomatous inflammation and suggest the importance of combining analysis of this and other enzymes known to be altered by chronic or subacute injury for chronic inflammation of tissues.

TL;DR: A simple and accurate method is described to measure the rate of pinocytosis by arterial cells in culture using 125 I-labeled polyvinylpyrrolidone (PVP) as a nondegradable marker molecule for fluid pinocyTosis.

TL;DR: By 14 days of recovery, cells from previously treated rats were indistinguishable in size from controls, and it was found that the protein content of the cells and the activities of the lysosomal hydrolases β-N-acetylglucosaminidase and β-galactosidase were elevated as a result of drug treatment and all had returned to the control levels by 14 Days of recovery.

TL;DR: Reasor and Koshut as discussed by the authors reported that after withdrawal of the rats from chlorphentermine treatment, the phospholipid content of the macrophages returned to the control level by 14 days of recovery.

TL;DR: In addition to developing aortic lesions readily on a cholesterol diet, these hybrids show marked stenotic lesions in the extramyocardial coronaries, and are therefore tentatively considered a promising model for the study of atherogenesis.

TL;DR: The failure of dithiothreitol to alter the metabolic pattern of HgCl2-induced ARF indicated that its protective effect was probably not mediated directly through the maintenance of adenine nucleotide levels, and was consistent with the idea that HGCl2 exerts a direct action on the enzymes of the mitochondrial electron transport chain.

TL;DR: The observations suggest that the change from ditypism to monotypism reported earlier with these cholesterol oxidation products was the result of progressive elimination of the europaeus type to leave only the timidus G-6-PD, consistent with the "selective advantage of one phenotype over the other" hypothesis for explaining the observed monotypesism.

TL;DR: The overall data suggest that focal differences in cellular azurophilia are attributable to differences in rates of uptake or accumulation of plasma constituents in Evans blue-permeable and impermeable aortic regions, and the permeability-associated increase in az Kurophilia is due to an increase in ribosomes and reflects a compensatory activation of metabolic processes in response to an increased uptake and transmural transport of plasma macromolecules.

TL;DR: The conclusion is that, if monocytes are present in substantial numbers, the calculations of smooth muscle cell divisions are higher than the actual number of divisions and thus the slowdown of division rates of individual lesion smooth muscle cells was even greater than that calculated herein.