Showing papers in "Journal of Abnormal Psychology in 2002"

Anxiety-Related Attentional Biases and Their Regulation by Attentional Control

Abstract: This study examined the role of self-reported attentional control in regulating attentional biases related to trait anxiety. Simple detection targets were preceded by cues labeling potential target locations as threatening (likely to result in negative feedback) or safe (likely to result in positive feedback). Trait anxious participants showed an early attentional bias favoring the threatening location 250 ms after the cue and a late bias favoring the safe location 500 ms after the cue. The anxiety-related threat bias was moderated by attentional control at the 500-ms delay: Anxious participants with poor attentional control still showed the threat bias, whereas those with good control were better able to shift from the threatening location. Thus, skilled control of voluntary attention may allow anxious persons to limit the impact of threatening information.

Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum

Abstract: A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style. The model posits a spectrum of personality and psychopathology, united by an externalizing factor linked to each phenotype within the spectrum, as well as specific factors that account for distinctions among phenotypes within the spectrum. This model fit self-report and mother-report data from 1,048 male and female 17-year-old twins. The variance of the externalizing factor was mostly genetic, but both genetic and environmental factors accounted for distinctions among phenotypes within the spectrum. These results reconcile evidence for general and specific causal factors within the externalizing spectrum and offer the externalizing factor as a novel target for future research.

Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias.

Abstract: Although it is well-established that vulnerability to negative emotion is associated with attentional bias toward aversive information, the causal basis of this association remains undetermined. Two studies addressed this issue by experimentally inducing differential attentional responses to emotional stimuli using a modified dot probe task, and then examining the impact of such attentional manipulation on subsequent emotional vulnerability. The results supported the hypothesis that the induction of attentional bias should serve to modify emotional vulnerability, as revealed by participants' emotional reactions to a final standardized stress task. These findings provide a sound empirical basis for the previously speculative proposal that attentional bias can causally mediate emotional vulnerability, and they suggest the possibility that cognitive-experimental procedures designed to modify selective information processing may have potential therapeutic value.

The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder.

Abstract: This study examined the persistence of attention-deficit/hyperactivity disorder (ADHD) into young adulthood using hyperactive (N = 147) and community control (N = 71) children evaluated at ages 19-25 years. ADHD was rare in both groups (5% vs. 0%) based on self-report but was substantially higher using parent reports (46% vs. 1.4%). Using a developmentally referenced criterion (+2 SD), prevalence remained low for self-reports (12% vs. 10%) but rose further for parent reports (66% vs. 8%). Parent reports were more strongly associated with major life activities than were self-reports. Recollections of childhood ADHD showed moderate correlations with actual parent ratings collected in childd hood, which suggests some validity for such recollections. The authors conclude that previous follow-up studies that relied on self-reports might have substantially underestimated the persistence of ADHD into adulthood.

Age, gender, race, socioeconomic status, and birth cohort difference on the children's depression inventory: A meta-analysis.

Abstract: A within-scale meta-analysis was performed on 310 samples of children (ages 8-16; N = 61,424) responding to the Children's Depression Inventory (CDI). Girls' depression scores stayed steady from ages 8 to 11 and then increased between ages 12 and 16. Boys' CDI scores were stable from ages 8 to 16 except for a high CDI score at age 12. Girls' scores were slightly lower than boys' during childhood, but girls scored higher beginning at age 13. There were no socioeconomic status effects and no differences between White and Black samples. However, Hispanic samples scored significantly higher on the CDI. Analyses for birth cohort showed a slight decrease in boys' CDI scores over time and no change for girls. Longitudinal studies demonstrated a marked testing effect.

Confirmatory factor analyses of posttraumatic stress symptoms in deployed and nondeployed veterans of the Gulf War.

Abstract: Confirmatory factor analysis was used to compare 6 models of posttraumatic stress disorder (PTSD) symptoms, ranging from 1 to 4 factors, in a sample of 3,695 deployed Gulf War veterans (N = 1,896) and nondeployed controls (N = 1,799) The 4 correlated factors-intrusions, avoidance, hyperarousal, and dysphoria-provided the best fit The dysphoria factor combined traditional markers of numbing and hyperarousal Model superiority was cross-validated in multiple subsamples, including a subset of deployed participants who were exposed to traumatic combat stressors Moreover, convergent and discriminant validity correlations suggested that intrusions may be relatively specific to PTSD, whereas dysphoria may represent a nonspecific component of many disorders Results are discussed in the context of hierarchical models of anxiety and depression

Reasons for suicide attempts and nonsuicidal self-injury in women with borderline personality disorder.

Abstract: Self-reported reasons for suicide attempts and nonsuicidal self-injury were examined using the Parasuicide History Interview within a sample of chronically suicidal women meeting criteria for borderline personality disorder (N = 75) Overall, reasons given for suicide attempts differed from reasons for nonsuicidal self-injury Nonsuicidal acts were more often reported as intended to express anger, punish oneself, generate normal feelings, and distract oneself, whereas suicide attempts were more often reported as intended to make others better off Almost all participants reported that both types of parasuicide were intended to relieve negative emotions It is likely that suicidal and nonsuicidal parasuicide have multiple intents and functions

Distress tolerance and duration of past smoking cessation attempts.

Abstract: The present study tested the hypothesis that limited ability to tolerate physical and psychological distress is associated with early relapse from smoking cessation. Specifically, the authors exposed 16 current smokers who had failed to sustain any previous quit attempt for more than 24 hr (immediate relapsers) and 16 smokers with at least 1 sustained quit attempt of 3 months or longer (delayed relapsers) to psychological (mental arithmetic) and physical (carbon dioxide inhalation-breath holding) stressors. Relative to delayed relapsers, immediate relapsers were characterized by higher baseline levels of affective vulnerability, by greater levels of dysphoria and urge to smoke after 12 hr of nicotine deprivation, and by less task persistence on the stressors, suggesting that these may be risk factors for early lapse in the context of quitting smoking.

Behavioral activation and inhibition systems and the severity and course of depression.

Abstract: Theorists have proposed that depression is associated with abnormalities in the behavioral activation (BAS) and behavioral inhibition (BIS) systems. In particular, depressed individuals are hypothesized to exhibit deficient BAS and overactive BIS functioning. Self-reported levels of BAS and BIS were examined in 62 depressed participants and 27 nondepressed controls. Clinical functioning was assessed at intake and at 8-month follow-up. Relative to nondepressed controls, depressed participants reported lower BAS levels and higher BIS levels. Within the depressed group, lower BAS levels were associated with greater concurrent depression severity and predicted worse 8-month outcome. Levels of both BIS and BAS showed considerable stability over time and clinical state. Overall, results suggest that BAS dysregulation exacerbates the presentation and course of depressive illness.

In cold blood: characteristics of criminal homicides as a function of psychopathy.

Abstract: This study investigated the relationship between psychopathy and the characteristics of criminal homicides committed by a sample of 125 Canadian offenders. It was hypothesized that the homicides committed by psychopathic offenders would be more likely to be primarily instrumental (i.e., associated with premeditation, motivated by an external goal, and not preceded by a potent affective reaction) or “cold-blooded” in nature, whereas homicides committed by nonpsychopaths often would be “crimes of passion” associated with a high level of impulsivity/reactivity and emotionality. The results confirmed these predictions; homicides committed by psychopathic offenders were significantly more instrumental than homicides by nonpsychopaths. Nearly all (93.3%) of the homicides by psychopaths were primarily instrumental in nature compared with 48.4% of the homicides by nonpsychopaths. In terms of its impact on the victim, the victim’s family and friends, and the financial resources devoted to its investigation, homicide is the most severe form of antisocial behavior. Despite its extreme negative consequences, homicide is also one of the least studied and most poorly understood forms of antisocial conduct. An obvious reason for the lack of research on the psychology of homicide is that it is uncommon compared with other forms of antisocial and violent behavior. However, it remains a significant problem within all cultures and nations (e.g., Daly & Wilson, 1988). Homicide is a heterogeneous phenomenon, associated with different contexts, motivations, and types of perpetrators. For example, some homicides are highly calculated, instrumental acts, whereas others are characterized by an apparent lack of premeditation, occurring in the context of an emotion-laden dispute or in response to a situational provocation. Research leading to a more thorough understanding of the factors associated with different forms of homicidal violence could have both basic and applied implications. As an example of the latter, if specific psychological characteristics in offenders were found to be associated with characteristics of the crime itself, it could allow investigators to reduce the large field of suspects in many homicide cases (e.g.,

Implicit and explicit alcohol-related cognitions in heavy and light drinkers

Abstract: Implicit and explicit alcohol-related cognitions were measured in 2 dimensions: positive-negative (valence) and arousal-sedation, with 2 versions of the Implicit Association Test (IAT; A. G. Greenwald, D. E. McGhee, & J. L. Schwartz) and related explicit measures. Heavy drinkers (n = 24) strongly associated alcohol with arousal on the arousal IAT (especially men) and scored higher on explicit arousal expectancies than light drinkers (n = 24). On the valence IAT, both light and heavy drinkers showed strong negative implicit associations with alcohol that contrasted with their positive explicit judgments (heavy drinkers were more positive). Implicit and explicit cognitions uniquely contributed to the prediction of 1-month prospective drinking. Heavy drinkers' implicit arousal associations could reflect the sensitized psychomotor-activating response to drug cues, a motivational mechanism hypothesized to underlie the etiology of addictive behaviors.

Immediate antecedents of cigarette smoking: An analysis from ecological momentary assessment.

Abstract: The authors assessed the association between smoking and situational cues, including affect, in real-world contexts. Using ecological momentary assessment, 304 smokers monitored ad-lib smoking for 1 week, recording each cigarette on palm-top computers. Generalized estimating equations contrasted 10,084 smoking and 11,155 nonsmoking situations. After controlling for smoking restrictions, smoking was strongly related to smoking urges and modestly related to consumption of coffee and food, the presence of other smokers, and several activities. Smoking was unrelated to negative or positive affect or to arousal, although it was associated with restlessness. Thus, in daily life, affect appears to exert little influence over ad-lib smoking in heavy smoking adults.

Do boys with attention-deficit/hyperactivity disorder have positive illusory self-concepts?

Abstract: One hundred ninety-five boys with attention-deficit/hyperactivity disorder (ADHD) were compared with 73 comparison boys (M = 9.83 years, SD = 1.30) on self-perceptions relative to a teacher-rated criterion. Emphasis was placed on ADHD subgroup comparisons according to level of aggression, academic achievement, and depression compared with control boys. Consistent with the authors' prediction, ADHD boys overestimated relative to teacher report, more than did controls, in the scholastic competence, social acceptance, and behavioral conduct domains. Examination of discrepancy scores (child rating - teacher rating) by comorbidity subgroups suggested that aggressive and low-achieving ADHD boys tended to overestimate their competence the most in the domains in which they were the most impaired. Results are discussed in terms of prior literature on "positive illusions" in ADHD children.

The latent structure of posttraumatic stress disorder: A taxometric investigation of reactions to extreme stress.

Abstract: Mental health professionals have debated whether posttraumatic stress disorder (PTSD) can be qualitatively distinguished from normal reactions to traumatic events. This debate has been fueled by indications that many trauma-exposed individuals evidence partial presentations of PTSD that are associated with significant impairment and help-seeking behavior. The authors examined the latent structure of PTSD in a large sample of male combat veterans. Three taxometric procedures-MAMBAC, MAXEIG, and L-Mode-were performed with 3 indicator sets drawn from a clinical interview and a self-report measure of PTSD. Results across procedures, consistency tests, and analysis of simulated comparison data all converged on a dimensional solution, suggesting that PTSD reflects the upper end of a stress-response continuum rather than a discrete clinical syndrome.

Response-monitoring dysfunction in schizophrenia: An event-related brain potential study.

Abstract: Error-monitoring abnormalities may underlie positive symptoms of schizophrenia. Response-synchronized event-related potentials during picture-word matching yielded error- and correct-response-related negativity (ERN, CRN) and positivity (Pe, Pc) and preresponse lateralized readiness potentials (LRP) from 18 schizophrenic patients and 18 controls. Both groups responded faster to matches than nonmatches, although patients were generally slower and made more errors to nonmatches. Compared with controls, patients, particularly with paranoid subtype, had smaller ERNs and larger CRNs, which were indistinguishable. LRPs showed evidence of more response conflict before errors than before correct responses in controls but not patients. Despite ERN/CRN abnormalities, post-error slowing and Pe were normal in patients, suggesting a dissociation of ERN and error awareness. Anterior cingulate and dorsolateral prefrontal cortical dysfunction in schizophrenia are implicated.

Cognitive impairments associated with formal thought disorder in people with schizophrenia.

Abstract: Formal thought disorder (FTD), or disorganized speech, is one of the central signs of schizophrenia. Despite extensive research, the cognitive processes associated with FTD are still unclear. However, the authors' review of FTD theories and research indicates that considerable progress has been made in identifying possible cognitive impairments associated with FTD. Specifically, FTD is strongly associated with impaired executive functioning and with impaired processing of semantic information. Their review indicates that previous research has not yet supported an association between FTD and either an increase in spreading activation or an impairment within the language production system.

Personality and the genetic risk for alcohol dependence.

Abstract: The extent to which the genetic risk for alcohol dependence (AD) and conduct disorder (CD) and their common genetic risk overlap with genetic factors contributing to variation in dimensions of personality was examined in a study of 6,453 individuals from 3,383 adult male and female same-sex and unlike-sex twin pairs from the Australian Twin Registry. The associations between the personality dimensions of positive emotionality, negative emotionality, and AD and CD risk were modest, whereas the associations between behavioral undercontrol and AD and CD risk were substantially higher. Genetic influences contributing to variation in behavioral undercontrol accounted for about 40% of the genetic variation in AD and CD risk and about 90% of the common genetic risk for AD and CD. These results suggest that genetic factors contributing to variation in dimensions of personality, particularly behavioral undercontrol, account for a substantial proportion of the genetic diathesis for AD and most of the common genetic diathesis for AD and CD among both men and women.

Turning a deaf ear to fear: impaired recognition of vocal affect in psychopathic individuals.

Abstract: The processing of emotional expressions is fundamental for normal socialization and interaction Reduced responsiveness to the expressions of sadness and fear has been implicated in the development of psychopathy (R J R Blair, 1995) The current study investigates the ability of adult psychopathic individuals to process vocal affect Psychopathic and nonpsychopathic adults, defined by the Hare Psychopathy Checklist-Revised (PCL-R; R D Hare, 1991), were presented with neutral words spoken with intonations conveying happiness, disgust, anger, sadness, and fear and were asked to identify the emotion of the speaker on the basis of prosody The results indicated that psychopathic inmates were particularly impaired in the recognition of fearful vocal affect These results are interpreted with reference to the low-fear and violence inhibition mechanism models of psychopathy

Waxing and waning in concert: dynamic comorbidity of conduct disorder with other disruptive and emotional problems over 7 years among clinic-referred boys.

Abstract: Six waves of structured diagnostic assessments were conducted of 168 clinic-referred 7- to 12-year-olds, over 7 years. Wave-to-wave changes in the number of conduct disorder (CD) behaviors were paralleled by correlated changes in the numbers of symptoms of oppositional defiant disorder (ODD), attention-deficit/hyperactivity disorder (ADHD), depression, and anxiety. In addition, CD in Wave 1 predicted levels of ODD, ADHD, depression, and anxiety in later waves when initial levels of those symptoms were controlled, but only ODD in Wave 1 predicted CD in later waves when initial CD levels were controlled. These findings indicate a striking degree of dynamic comorbidity between CD and other types of psychopathology and provide an initial empirical framework for needed developmental models of comorbidity.

Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism?

Abstract: This study tested the hypothesis that dorsolateral prefrontal cortex deficits contribute to both working memory and long-term memory disturbances in schizophrenia. It also examined whether such deficits were more severe for verbal than nonverbal stimuli. Functional magnetic resonance imaging was used to assess cortical activation during performance of verbal and nonverbal versions of a working memory task and both encoding and recognition tasks in 38 individuals with schizophrenia and 48 healthy controls. Performance of both working memory and long-term memory tasks revealed disturbed dorsolateral prefrontal cortex activation in schizophrenia, although medial temporal deficits were also present. Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed.

Individual differences in the emergence of depressive symptoms in children and adolescents: a longitudinal investigation of parent and child reports.

Abstract: The authors address questions about the rate that depressive symptoms emerge, developmental and gender differences in this rate, and differences between parent and child estimates of this rate. In a 12-wave, cohort-sequential, longitudinal design, 1,570 children (Grades 4-11) and parents completed reports about children's depression. Cross-domain latent growth curve analysis revealed that (a) the rate of symptom growth varied with developmental level. (b) gender differences symptom growth preceded emergence of mean level gender differences, (c) the rate of symptom development varied with age, and (d) parent-child agreement about rate of symptom change was stronger than agreement about time-specific symptoms. The authors suggest that predictability of depressive symptoms varies with age and the dimension under investigation.

A longitudinal investigation of anxiety sensitivity in adolescence.

Abstract: This investigation sought to expand existing knowledge of anxiety sensitivity in a sample of high school students (N = 2,365) assessed over 4 years. The stability of anxiety sensitivity levels across assessment periods was examined, and cluster analyses were used to identify different developmental pathways in levels of anxiety sensitivity. Groups of adolescents with stable low, stable high, and escalating anxiety sensitivity levels were identified. Adolescents with stable high or escalating anxiety sensitivity were significantly more likely to report experiencing a panic attack than individuals with stable low anxiety sensitivity. Results also indicated that Asian and Hispanic adolescents tended to report higher anxiety sensitivity but that their anxiety sensitivity was less strongly associated with panic than that of Caucasian adolescents.

Reappraising the link between peritraumatic dissociation and PTSD symptom severity: evidence from a longitudinal study of community violence survivors.

Abstract: Cross-lagged panel analysis of longitudinal data collected from young adult survivors of community violence was used to examine the relationship between recall of peritraumatic dissociation and posttraumatic stress disorder (PTSD) symptom severity. Recollections of peritraumatic dissociation assessed within days of exposure differed from recollections measured at 3- and 12-month follow-up interviews. Peritraumatic dissociation was highly correlated with PTSD symptoms within each wave of data collection. Baseline recollections of peritraumatic dissociation were not predictive of follow-up PTSD symptom severity after controlling for baseline PTSD symptom severity. This pattern of results replicates previous work demonstrating a correlation between peritraumatic dissociation and subsequent symptom severity. However, findings are not consistent with the prevailing view that peritraumatic dissociation leads to increased PTSD symptom severity.

Implicit and explicit attitudes toward high-fat foods in obesity.

Abstract: This study examined implicit and explicit attitudes toward high-fat foods in obese ( n 30) and normal-weight controls (n 31). The Implicit Association Test (A. G. Greenwald, D. E. McGee, & J. L. K. Schwartz, 1998) was used to measure the differential association of the 2 target categories— high-fat vs. low-fat food words—with an attribute dimension (positive vs. negative). Results suggest that obese people are characterized by a significantly stronger implicit negative attitude toward high-fat foods than are normal-weight controls. This implicit negative attitude is contradictory to their preferences and behavior: Several studies indicate that obese people prefer and consume high-fat foods. Apparently, obese people like the taste of high-fat foods but not the fat content itself, not only on the explicit but also on the implicit level. One of the main questions in obesity research is how people become obese. Various food studies have shown that obesity is more strongly related to the percentage of fat in a diet than to total energetic intake: Obese people’s diets contain considerably more fat than the diets of normal-weight people (e.g., Capaldi, 1996; Drewnowski, 1996). The higher fat intake of obese people may be related to their larger preference for high-fat foods: Several studies found that obese people’s preference for foods was determined more by fat content than by carbohydrate or sucrose content. Moreover, they showed a larger preference for high-fat foods than did normal-weight controls (e.g., Capaldi, 1996; Drewnowski, 1991; Drewnowski, Brunzell, Sande, Iverius, & Greenwood, 1985; Drewnowski & Greenwood, 1983; Drewnowski, Kurth, HoldenWiltse, & Saari, 1992; Reed, Bachmanov, Beauchamp, Tordoff, & Price, 1997). Taste preferences might be considered evaluative categorizations. Evaluative categorizations such as positive–negative can be fast, preconscious, and automatic (e.g., Fazio, Sanbonmatsu, Powell, & Kardes, 1986; Hermans & Eelen, 1997). Taste preferences can be seen, therefore, as a special kind of automatic evaluative categorization, that is, in terms of palatable and unpalatable. Conceptualizing taste preferences as automatic evaluative categorizations leads to the prediction that the obese will not only show an explicit behavioral response to high-fat foods but also a fast, preconscious, and automatic preference for these foods. In this study, we examined the role of preconscious affective processes in the preference for high-fat foods. In particular, we tested whether obese people show a larger preconscious, automatic, positive response when presented with high-fat food words than do normal-weight controls. If obese participants show an implicit preference for high-fat foods, their preference for high-fat foods might not be changed easily.

Moderators of the relation between substance use level and problems: test of a self-regulation model in middle adolescence.

Abstract: The authors tested predictions, derived from a self-regulation model, about variables moderating the relationship between level of substance use (tobacco, alcohol, and marijuana) and problems associated with use. Data were from two independent studies of adolescents, with mean ages of 15.4 and 15.5 years (Ns = 1,699 and 1,225). Factor analysis indicated correlated dimensions of control problems and conduct problems. Protective moderation was found for variables indexing good self-control; risk-enhancing moderation was found for variables indexing poor self-control. These effects were generally independent of deviance-prone attitudes and externalizing symptomatology. Multiple-group structural modeling indicated moderation occurred for paths from life stress and coping motives and for paths from level to control and conduct problems. Moderation effects were also found for parental variables, peer variables, and academic competence.

Emotion among women with psychopathy during picture perception.

Abstract: Emotional reactions in women with psychopathy were examined in a mixed-picture paradigm using psychophysiological measures. Startle probes were presented at 2.0 or 4.5 s following onset of a 6-s picture presentation. At 2.0 s, nonpsychopaths exhibited the typical pattern of eyeblink reflex magnitude: unpleasant > neutral > pleasant. Psychopaths with high general levels of anxiety also exhibited this pattern. Psychopaths with lower anxiety exhibited attenuated reflex magnitudes during unpleasant pictures. Similarly, when focusing on psychopathy components, only individuals expressing high antisocial behavior and high emotional detachment exhibited smaller reflex magnitudes during unpleasant pictures. At 4.5 s, all groups exhibited normal, potentiated reflex magnitudes during unpleasant pictures. Group differences were not observed for other measures.

Interpretation revealed in the blink of an eye: depressive bias in the resolution of ambiguity.

Abstract: Self-report measures of interpretation have been criticized on methodological grounds. An approach is introduced in this article that enables the assessment of interpretive bias with a greater degree of methodological rigor than previously has been the case. Psychophysiological researchers have established that the magnitude of the human blink reflex is augmented when elicited during negative rather than neutral imagery. The 1st experiment demonstrates that the blink reflex is sensitive to the emotional valence of imagery evoked by interpretations imposed on ambiguous stimuli. In the 2nd experiment, this measure is used to assess interpretations imposed on ambiguous stimuli by individuals who differ in depression levels. The findings are consistent with the hypothesis that depression is associated with a negative interpretive bias.

Memory distortion in people reporting abduction by aliens.

Abstract: False memory creation was examined in people who reported having recovered memories of traumatic events that are unlikely to have occurred: abduction by space aliens. A variant of the Deese/Roediger-McDermott paradigm (J. Deese. 1959; H. L. Roediger III & K. B. McDermott, 1995) was used to examine false recall and false recognition in 3 groups: people reporting recovered memories of alien abduction. people who believe they were abducted by aliens but have no memories, and people who deny having been abducted by aliens. Those reporting recovered and repressed memories of alien abduction were more prone than control participants to exhibit false recall and recognition. The groups did not differ in correct recall or recognition. Hypnotic suggestibility, depressive symptoms, and schizotypic features were significant predictors of false recall and false recognition.

The DRD4 VNTR polymorphism influences reactivity to smoking cues.

Abstract: Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer) allele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.

Effects of nicotine dose, instructional set, and outcome expectancies on the subjective effects of smoking in the presence of a stressor

Abstract: The balanced placebo design (BPD) was used to evaluate the independent effects of nicotine dose and smoking-related expectancies on self-reported anxiety, urge to smoke, and withdrawal symptoms. After anxious mood was induced, participants smoked either a de-nicotinized cigarette or one with standard nicotine content. Nicotine dose was crossed with instructions that the cigarette was either de-nicotinized or standard. Nicotine cigarettes produced greater anxiety reduction than de-nicotinized cigarettes. Nicotine instructions attenuated anxiety only among those who held relevant expectancies. Nicotine dose and instructional set interacted such that either nicotine cigarettes or instructions that the cigarettes contained nicotine were sufficient to reduce urge to smoke. Implications of these findings and methodological issues regarding use of the BPD with cigarettes are discussed.