Showing papers in "Journal of Controlled Release in 1988"

TL;DR: The authors suggest that miniaturization of iontophoretic devices and electrodes and prevention of any possibility of skin burns are required to make this technique useful for biomedical applications.

TL;DR: Hydrophobic polyamine copolymer hydrogels, loaded with caffeine, release the drug at rates that vary sharply with pH, providing strong evidence for a moving front mechanism for sorption and release.

TL;DR: In this paper, various cisplatin-loaded microsphere systems have been prepared from d,l -lactic acid stereocopolymers and d, lactic acid/glycolic acid copolymers using a solvent evaporation process.

TL;DR: In this paper, microspheres containing 13-16% l-methadone were prepared from three biodegradable polymers, poly( l -lactic acid), PLLA; poly (glycolic acid-co- l-lactic acids), PGLA; and poly (ϵ-caprolactone-co − l - lactic acid) PCL-LA, using the solvent evaporation method.

TL;DR: In this paper, a new model was developed to account for the kinetics of drug release from porous, non-swellable polymeric microparticles in the case where both drug dissolution and diffusion mechanisms control the overall release process.

TL;DR: The effect of alcoholic penetration enhancers on the transdermal delivery of levonorgestrel (LN) was investigated in this article using donor phase compositions of water fethanol mixtures, and the neat straight chain alkanols ethanol, propanol, butanol, pentanol, hexanol, and octanol.

TL;DR: It is demonstrated that the Ussing chamber provides a useful technique to investigate the nasal transport of drugs and allows evaluation of the effects of absorption enhancers on both absorption and tissue integrity.

TL;DR: Les dispositifs d'autoregulation de la liberation des principes actifs in les systemes de delivrance des formes a liberation controlee peuvent agir par un mecanisme de desorption ou de reaction enzyme substrat as discussed by the authors.

TL;DR: Two polymeric prodrug models containing oligopeptide side-chains terminating in drug have been synthesized and the inhibition of cathepsin C by one of the products of cleavage (Phe-Gly) was observed.

TL;DR: In this paper, the authors measured the permeability of hydrated calcium alginate films with side-byside glass diffusion cells and found that the films were prepared by ionically crosslinking dry sodium alginates by immersion in aqueous solutions of calcium acetate for 1 to 15 minutes.

TL;DR: The results of the short-term clinical study indicate that use of the device in periodontal pockets may cause complete eradication of the pathogenic bacteria from the pocket.

TL;DR: In this article, the authors used steam injection cooking of cornstarch or mixtures of starches with varying amylose content, followed by active agent addition, drying and grinding yields encapsulated products showing controlled slow release of active agent.

TL;DR: A simple method to entrap pesticides under mild conditions is described in this paper, where a mixture of pregelatinized starch or ungelatinizing starch containing a gelatinizing agent is added to allow agglomeration into 12- to 40-mesh granules.

TL;DR: In vitro, in vivo performance, and model calculations of drug release from the morantel sustained release trilaminate (MSRT, Paratect Flex bolus — Pfizer Inc.) are presented.

TL;DR: It is concluded that lidocainepolyurethane controlled release matrices can be fabricated with a broad range of initial release profiles, and that these matrix can rapidly initiate the conversion of ouabain-induced ventricular tachycardia to normal sinus rhythm.

TL;DR: Microspheres prepared from transferrin, haemoglobin and polyaspartic acid in admixture with albumin have been evaluated as alternatives to albumin systems as vehicles for the anti-cancer drug adriamycin, and data indicate that a proportion of drug is present in other than native form in microsphere prepared from pure proteins.

TL;DR: The bioactivity of the highly volatile herbicide EPTC was retained on a wet soil surface for 6 to 8 days by starch encapsulation utilizing several crosslinking processes (both chemical and non-chemical) and starches with different ratios of amylopectin to amylose.

TL;DR: In this article, the authors modeled penetration-activated solute release in polymers undergoing case-II penetrant uptake and showed that swelling of a polymer slab can have a significant effect on release behavior.

TL;DR: In this article, the leaching/retention of a variety of aqueous soluble polymers from blends with ethylcellulose has been studied using combined torsional braid analysis and gravimetric analysis.

TL;DR: The FDA's procedure/method was found to be simple, reproducible and applicable for in vitro release characterization of all brands of marketed patches.

TL;DR: In this paper, the authors reported the presence of cell-type patterns on the surface of poly(2-hydroxyethyl methacrylate-co-methacrylic acid) during planar swelling in a buffered solution of pH = 10 at 27.5° C.

TL;DR: The results indicate that the structure of LN can be modified by the prodrug approach to increase the flux of Ln through rat skin in vitro.

TL;DR: It was demonstrated that the estradiol release from both the COMPUDUCE® 200 andCOMPUDOSE® 400 products was identical for 270 days in vitro and 308 days in vivo.

TL;DR: In this article, the performance of copolymers with pendent esters of the plant growth regulators naphthaleneacetic acid and indole acetic acid has been studied utilizing reversed phase liquid chromatography with ultraviolet spectrometric detection.

TL;DR: In vitro release rates of the anti-cancer drug adriamycin have been studied following its incorporation into microspheres prepared from albumin, transferrin, haemoglobin and an albumin/polyaspartic acid mixture, with the conclusion that the release process is best described as triphasic zero order.

TL;DR: In the development of controlled release dosage forms for these species, ease of administration and parenteral products that are non-irritating to tissues must be given priority.

TL;DR: In this paper, a mechanism is proposed in which rupture formation is caused by deswelling of the hydrogels, and it is also shown that by careful manipulation of the rupturing process it is possible to change a matrix-type delivery into a release profile approaching zero order release.