Journal ArticleDOI
Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways
TLDR
This review focuses on the chemical structure of the polysorbates, factors influencing micelle formation and factors and excipients influencing stability and degradation of thepolyethylene and fatty acid ester linkages.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2008-08-01. It has received 638 citations till now. The article focuses on the topics: Polysorbate & Polysorbates.read more
Citations
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Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
TL;DR: Recent advances in formulation and delivery strategies, such as the use of microsphere-based controlled-release technologies, protein modification methods that make use of polyethylene glycol and other polymers, and genetic manipulation of biopharmaceutical drugs are highlighted and discussed.
Journal ArticleDOI
Protein aggregation: Pathways, induction factors and analysis
TL;DR: This review gives a short outline of currently discussed pathways and induction methods for protein aggregation and describes currently employed set of analytical techniques and emerging technologies for aggregate detection, characterization and quantification.
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Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development
TL;DR: Key mechanisms of protein-excipient interactions such as electrostatic and cation-pi interactions, preferential hydration, dispersive forces, and hydrogen bonding are presented in the context of different physical states of the formulation.
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Immunogenicity of therapeutic proteins: Influence of aggregation
TL;DR: An overview of the phenomenon of protein aggregation, the production of unwanted aggregates during bioprocessing, and how the immune response to aggregated protein differs from that provoked by non-aggregated protein is provided.
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Lipid Oxidation in Oil‐in‐Water Emulsions: Involvement of the Interfacial Layer
TL;DR: In this paper, the state-of-the-art on lipid oxidation in oil-in-water (O/W) emulsions, with an emphasis on the role of the interfacial region.
References
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The Hydrophobic Effect: Formation of Micelles and Biological Membranes
TL;DR: In this article, the authors discuss the properties of water molecules and their relationship with common soluble proteins, such as membrane proteins and membrane membrane proteins, as well as the effect of temperature on their properties.
Journal ArticleDOI
Mechanisms of free radical oxidation of unsaturated lipids
TL;DR: The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.
Journal ArticleDOI
A review on experimental studies of surfactant adsorption at the hydrophilic solid-water interface.
Santanu Paria,Kartic C. Khilar +1 more
TL;DR: Influence of different parameters such as molecular structure, temperature, salt concentration, and salt concentration that are very important in surfactant adsorption are reviewed here.
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A View of the Hydrophobic Effect
TL;DR: Experimental and theoretical studies of nonpolar solute partitioning into water are surveyed and it is noted that the hydrophobic effect is not just due to “water ordering” and not merely due to small size effects of water.