Showing papers in "Molecular and Cellular Endocrinology in 1982"

TL;DR: It is concluded that besides direct transcriptional regulation, androgens must also exert a major effect of the half-life of these mRNAs in the rat ventral prostate.

TL;DR: Results show that LHRH analogues do not bind to or have any detectable effect on mouse Leydig cells in vitro, however, L HRH analogue does bind specifically to purified rat LeydIG cells.

TL;DR: Electrophoresis and thin-layer chromatography showed that the radioactive GAG produced by bovine cumulus-oocyte complexes was hyaluronic acid.

TL;DR: Results show that the secretory activity of the Sertoli cells (ABP) is influenced by the type of germ cell at each cell association, which is of importance for the normal maintenance of spermatogenesis.

TL;DR: Data show that TSH, which stimulates the function of thyroid tissue, in vivo and in vitro, activates the multiplication of differentiated dog-thyroid follicular cells in primary culture, which suggests that this trophic effect is, partly at least, mediated by cyclic AMP.

TL;DR: The results indicate that the presence of serum in the cell culture medium inhibits the responsiveness of luteal cells to LH at a step prior to the increase in cellular cAMP, and that serum lipoproteins can be used to increase progesterone production by cultured bovine luteAL cells.

TL;DR: The production of inhibin by cultures of Sertoli cells from 21-day-old rats was assessed by the use of an in vitro bioassay using rat pituitary cells in culture and a dose-dependent increase in inhibin activity was observed in the presence of graded doses of FSH.

TL;DR: Results are consistent with the hypothesis that LHRH causes a receptor-mediated increase in turnover of phosphatidylinositol and this may be among the early metabolic events in the mechanism of L HRH-stimulated LH secretion from the anterior pituitary gland.

TL;DR: It is shown for the first time that LHRH and its agonists can exert effects on Leydig cell steroidogenesis during short-term incubation, and that these effects are stimulatory, which contrasts with the inhibitory effects reported after long-term exposure.

TL;DR: The discovery of the unique sugar phosphate, fructose 2,6-bisphosphate, has been an important advance in the understanding of the regulation of carbohydrate metabolism in liver.

TL;DR: The alkylaminoethoxy side-chain is not only necessary for the antiestrogenic properties of both tamoxifen and trioxifene but also essential for the effective estrogen receptor binding and pharmacological actions of trioxIFene.

TL;DR: It is concluded that regulation of prolactin synthesis by estrogen is mediated predominantly but not exclusively through stimulation of gene expression in existing pituitary cells.

TL;DR: The presence of specific high-affinity ang Elliotensin II receptor in the anterior pituitary gland provides a mechanism by which angiotensin-like peptides could modulate the process of pituitsary hormone secretion.

TL;DR: The full integrity of the carbohydrate moiety in ovine follitropin is not required for effective receptor binding and immunological activity and deglycosylation rendered the hormone less acidic as reflected by altered electrophoretic mobility in polyacrylamide gels at pH 8.5.

TL;DR: It is reported that, while forskolin activates liver adenylate cyclase up to 15-fold, it does not activate cyclase of ram sperm which comprises a pure catalytic subunit, however, forSkolin activation of spermAdenylates cyclase activity could be observed after reconstitution with the regulatory component-enriched membrane from human erythrocytes.

TL;DR: The in vitro secretion profile of cultured rat cells is comparable with the early and late phases of LH release observed in GnRH-infused man, but occurs much more rapidly, and demonstrates heterogeneity of the LH release process at the level of the gonadotroph.

TL;DR: The overall agreement between CA activity and the JH hemolymph titers suggests that the in vitro system supports physiological gland activity and that changes in biosynthesis contribute significantly to changes in the titers.

TL;DR: The results imply that excessive levels of thyroid hormones over normal in the serum can lead to impairment of mitochondrial energy metabolism in a tissue-specific manner.

TL;DR: The most intensively studied species of the cellular slime molds is Dictyostelium discoideum, and it is a favorable subject because the amebae are activated by chemoattractants in their single-cell phase.

TL;DR: The stimulation of FSH or dibutyryl cAMP of the production of plasminogen activator activity was shown to be dependent upon de novo synthesis of RNA and protein, and the possible role of plAsminogen Activator in gonadal functions was discussed.

TL;DR: It is concluded that catecholamines stimulate testosterone production in mouse Leydig cells in monolayer culture and that this effect if mediated by cyclic AMP.

TL;DR: It is proposed that, in fasting, the loss of somatotropic binding sites in the liver is one of the possible causes of the decreased plasma somatomedin bioactivity.

TL;DR: The method used to demonstrate the involvement of VIP in a physiological regulation is described and illustrated by two examples: the effect of VIP on gut epithelium and the neuroendocrine action of VIPIn inducing prolactin release from pituitary cells.

TL;DR: The results show that the sharp decrease of the metabolic response of brown adipose tissue to nerve stimulation has multiple causes, suggesting the existence of an additional defective reaction which could occur between the binding to the beta-receptors and the activation of the triglyceride lipase.

TL;DR: The results demonstrate a role of cyclic AMP in the mechanism of LH/hCG receptor regulation by FSH but reveal that the mechanism is complex and suggest that some non-cyclicAMP actions are also involved.

TL;DR: It was deduced that aromatase induction was saturable under conditions where FSH-sensitive cAMP production and the induction of P biosynthesis showed further, proportionate increases, androgen potentiation of steroidogenic enzyme induction during F SH-stimulated granulosa cell differentiation may involve a suppression of cAMP catabolism exerted by way of the androgen-receptor system.

TL;DR: The results are consistent with the hypothesis that steroid effects rely on a mechanism involving alterations in protein synthesis; the affected proteins may be involved in the process of LHRH action.