Showing papers in "Neurobiology of Learning and Memory in 2006"

TL;DR: It is shown that, after a comparatively brief sleep episode, subjects that take a nap improve more on a declarative memory task than subjects that stay awake, but that improvement on a procedural memory task is the same regardless of whether subjects take aNap or remain awake.

TL;DR: The results suggest that E2 and progestins can have mnemonic effects through actions in the cortex and/or hippocampus through the effects of endogenous fluctuations in ovarian steroids in intact female rats.

TL;DR: Evidence is provided that mice are able to form an integrated memory for "what," "where," and "when" aspects of single experiences by combining different versions of the novelty-preference paradigm, and that this paradigm, with minor modifications, also works with rats.

TL;DR: In this paper, the effects of chronic restraint stress on a prefrontally mediated behavior, extinction of conditioned fear, were examined. And the results showed that one week of restraint stress specifically impaired recall of extinction, a pattern of deficits typical of animals with impaired medial prefrontal function.

TL;DR: It was determined that network-driven excitatory and inhibitory activities recorded in CA1 pyramidal neurons showed that the HRM had comparable amplitude and frequency of spontaneous excites, but a marked reduction in spontaneous inhibitory postsynaptic currents.

TL;DR: Evidence is provided that, as with original CFC learning, noradrenergic activation within the BLA modulates the consolidation of CFC extinction and the findings suggest that theBLA influence on extinction is not mediated by an interaction with the dorsal hippocampus.

TL;DR: Evidence is provided that, as found with other emotionally arousing tasks, the enhancing effects of corticosterone on memory consolidation of auditory-cue fear conditioning require posttraining noradrenergic activity within the BLA.

TL;DR: Evidence is generated of a close interaction between the anxiety trait, hippocampal MR expression and the learning abilities of individuals in stressful spatial orientation tasks.

TL;DR: It is concluded that the loss of sleep and the activities the mice engaged in during the SD, impaired recognition memory retrieval, when they occurred immediately after acquisition.

TL;DR: It is demonstrated that different types of enrichment in aged male mice have disparate effects on spatial memory, and that the relationship between enrichment-induced changes in synaptophysin levels and spatial memory in aged males differs from that the authors have previously reported in aged female mice.

TL;DR: Rlipram showed an improvement in long-term memory performance when injected 3 h after T1 at a dose of 0.03 mg/kg, and reversed the scopolamine-induced short- term memory deficit at a doses of0.1mg/kg.

TL;DR: Results suggest dCA1 and vCA1 groups show no significant deficits during acquisition when compared to control groups, and are suggestive of a graded involvement in contextual retention between the dorsal and ventral aspects of CA1.

TL;DR: E2's actions at ERbeta, rather than ERalpha, may enhance spatial memory, E2'sactions at ERalpha can facilitate sexual behavior, and that E1's actions involving both ERalpha and ERbeta may be important for emotional memory are suggested.

TL;DR: It is suggested that age-related changes in visuospatial function in the dog models that seen in humans are further validating the dog as a model for human aging and dementia; and other mechanisms, such as oxidative stress, soluble Abeta oligomers or cholinergic deficits, are likely contributing to the early impairment.

TL;DR: The present study emphasizes the importance of a well-substantiated choice of background strain and water maze characteristics when researchers plan to investigate visual-spatial learning and memory in a chemically/lesion-induced or targeted mutagenesis model.

TL;DR: It is demonstrated that neural discharge in vagal afferent fibers is increased by elevations in peripheral concentrations of epinephrine and the significance of these findings in understanding how epinphrine modulates brain limbic structures to encode and store new information into memory is discussed.

TL;DR: Results show that tetanic stimulation of perforant path sufficient to induce LTP increases progenitor proliferation in adult DG in an NMDA receptor-dependent manner, raising the possibility that LTP and neurogenesis are closely related.

TL;DR: Although general learning abilities are strongly related to individuals' propensity for exploration, this relationship is not attributable to variations in sensory/motor function or the individuals' physiological or behavioral sensitivity to conditions that promote stress or fear.

TL;DR: Examination of the effects of physiological levels of estradiol on the acquisition of a spatial working memory task mediated by the prefrontal cortex (PFC) and the hippocampus in well-trained rats suggests that facilitation or disruptions of working memory by Estradiol are site- and time-specific.

TL;DR: The results suggest that the elevated dopaminergic tone reduced the selectivity of stimulus control over conditioned behavior, but did not affect instrumental learning.

TL;DR: The data suggest that ICI may have some mixed agonist and antagonist effects in the hippocampus and that estrogen enhances place learning through activation of estrogen receptors located inThe hippocampus.

TL;DR: The known functions of low-density lipoprotein receptors are described and their potential role in processes of synaptic regulation and memory formation is discussed.

TL;DR: Examination of the influence of chemical inactivation of these nuclei of amygdala on the freezing and escape responses induced by electrical stimulation through electrodes implanted in the dPAG of Wistar rats shows that the amygdala can affect some, but not all, aspects of unconditioned freezing.

TL;DR: The data indicate that, when given into CA1, histamine enhances memory consolidation through a mechanism that involves activation of H2 receptors; however, endogenous CA1 histamine does not seem to participate in the consolidation of IA memory at least at the post-training times analyzed.

TL;DR: The experiments revealed that the relevant variable to induce CREB deactivation was the prolonged exploration of the arena, and suggested that CREB phosphorylation state in the hippocampus switches in response to exposure to a novel or to a familiar spatial environment.

TL;DR: Findings support a role for presynaptic m1 mAChRs in modulation of synaptic transmission in CA1, but indicate that other muscarinic receptor subtypes, such as M2, are also involved in suppression of synaptic potentials.

TL;DR: The morphine-induced recovery of memory, on the test day, seems to be induced, at least in part, through dopamine receptors.

TL;DR: A low level of acetylcholine released by the nucleus basalis during learning is sufficient to induce associativity whereas a higher level of release enables the storage of greater experiential detail, demonstrating that the amount of detail in memory can be directly controlled by neural intervention.

TL;DR: Evaluated brain structures anatomically and functionally linked to the hippocampus and amygdala in a fear-based context discrimination task showed damage to the fornix, medial prefrontal cortex, mediodorsal thalamic nucleus, and nucleus accumbens produced the largest impairment in context-specific fear responses.

TL;DR: The hypothesis that honeybee α-BGT-sensitive acetylcholine receptors are also sensitive to MLA could be essential for triggering intracellular mechanisms involved in LTM is advanced.