Showing papers in "Pediatric Neurology in 2012"

TL;DR: In this article, the prevalence of tic disorders in children was evaluated using MEDLINE and EMBASE databases, using terms specific to Tourette syndrome and Tic disorders, for studies of incidence, prevalence, and epidemiology.

TL;DR: The clinical assessment of sleep problems in this population of children with autism spectrum disorder and a management algorithm are presented.

TL;DR: Advances in the multidisciplinary supportive care of children with spinal muscular atrophy also offer hope for improved life expectancy and quality of life.

TL;DR: This work provides a framework for clinical and electrical events in electrical status epilepticus in sleep and identifies some "benign" pediatric focal epileptic syndromes that represent the mildest end of this continuum.

TL;DR: Despite the increasing number of single early-onset epileptic encephalopathy genes, the clinical presentations of these disorders frequently overlap, making it difficult to picture a systematic diagnostic evaluation, and a progressive approach should guide the choice of molecular genetic investigations.

TL;DR: The need for collaboration among neonatologists and neurologists is urgent, to address gaps in knowledge regarding management of neonatal seizures in term and preterm neonates.

TL;DR: This work reviews bothhtahara syndrome and early myoclonic encephalopathy, with particular focus on the underlying genetics and pathophysiology and implications regarding the classification of these conditions.

TL;DR: The early cerebral connective tract development of infants born to methadone-maintained mothers and comparison infants was examined using diffusion tensor imaging in this paper, showing that higher mean diffusivity was associated with delayed or altered maturation of neural connective tracts.

TL;DR: Lower axial diffusivity in motor and sensory tracts may be implicated in developmental coordination disorder, but replication in a larger study is needed to confirm these findings.

TL;DR: The majority of newborns screening positive for Krabbe disease have not exhibited the expected early infantile phenotype, with most clinically normal despite low galactocerebrosidase activity and two mutations, and most are expected to develop the later onset phenotypes.

TL;DR: The classification, clinical manifestations, electrophysiologic features, genetics, and treatment responses of each congenital myasthenic syndrome subtype are explored.

TL;DR: Etiology, Apgar score, need for resuscitation at birth, background electroencephalogram, neonatal status epilepticus, cranial imaging findings, type/duration of antiepileptic treatment, and response to acute treatment were all strong prognostic factors in neurologic outcomes.

TL;DR: Acute lymphoblastic leukemia chemotherapy regimens apparently comprised the main predisposing factors for posterior reversible encephalopathy syndrome complicated during induction chemotherapy, compared with hypertension and immunosuppressive agents after hematopoietic stem cell transplantation.

TL;DR: Children with clinical variants of Guillain-Barré syndrome are more likely to manifest rapid onset from disease onset to nadir, increasing the severity of disability, cranial nerve involvement, urine incontinence, respiratory impairment, and need for ventilator support than in typical Guillaine-B Barré syndrome.

TL;DR: Eye tracking represents a feasible method to assess cognition, and provide insights into the burden of isolation of these children and the mismatch between their social preferences and incompetence, caused by movement disorder and apraxia.

TL;DR: Although no treatment eliminated seizures, topiramate, vigabatrin, and the ketogenic diet were most helpful at reducing seizure frequency.

TL;DR: An overview of tuberous sclerosis complex and its molecular causes is given, and results from recent clinical trials of mammalian target of rapamycin inhibitors in patients with the disease are summarized.

TL;DR: Therapeutic hypothermia may play an important role in children with febrile infection-related epilepsy syndrome, and was reported effective in stabilizing immune activation, brain edema, and seizure activity and protecting the brain from ongoing functional, apoptotic neural, and glial damage and the systemic expansion of the cytokine storm.

TL;DR: Although characteristics of brain injury in children vary, subgroups of this population offer the potential to inform the understanding of developing brain structure-function relationships in response to intervention.

TL;DR: Progressive spastic diplegia constituted the key clinical abnormality in this group of patients, but variability in clinical presentation and progression were evident in this series.

TL;DR: It is concluded that obstructive sleep apnea surgery may decrease seizure frequency, especially in children with elevated body mass index scores and younger age at time of surgery.

TL;DR: Eye-tracking provides a feasible method for cognitive assessment and new insights into the "hidden" abilities of individuals with Rett syndrome, and basic features of visual processing (visual discrimination attention/memory) are examined.

TL;DR: A brief-targeted strategy provides a high yield for nonconvulsive seizure identification, but would fail to diagnose some patients with seizures, and should be considered when institutions develop clinical pathways for monitoring.

TL;DR: Although large lobar resections are often required, very localized, discrete resections may be possible, as in symptomatic Lennox-Gastaut syndrome (specifically, hypothalamic hamartoma), and the history of the disease and current management options are reviewed.

TL;DR: A 14-month-old girl with TUBA1A mutation-associated lissencephaly is described, and the clinical and neuroradiologic findings of 19 cases in the literature are summarized.

TL;DR: The findings suggest that the timing component of the unpaced rhythmic finger tapping task is less efficient and automatic in children, who need to recruit the superior vermis more intensively to maintain the rhythm, although they performed somewhat more poorly than adults.

TL;DR: Most cases attributable toperinatal brain injury, except for evolving hypoxic-ischemic encephalopathy, are not identified according to any perinatal characteristics until the onset of signs, limiting opportunities for prevention.

TL;DR: This case report is the first, to the best of the knowledge, of plasmapheresis because of Hashimoto encephalopathy in a child, and his level of anti-thyroid peroxidase antibody was high.

TL;DR: Amplitude-integrated electroencephalography (aEEG) was recently introduced into neonatal intensive care in the United States as mentioned in this paper, which has been evaluated whether aEEG has changed clinical care for neonates with seizures.

TL;DR: It is suggested that all children presenting with progressive neurodegeneration or spastic paraplegia in the absence of risk factors for cerebral palsy should be screened for inborn errors of metabolism, including arginase deficiency.