Showing papers in "Steroids in 2002"

TL;DR: This review article highlights some of the important advances in understanding the cell biology of estrogen action that emanates from the membrane.

TL;DR: The first evidence has now been found to suggest a physiological expression of membrane-bound glucocorticoid receptors on human cells, whereas in humans this had previously only been demonstrated on lymphoma cells.

TL;DR: Evidence from co-crystal structures of ER ligand-binding domains complexed with SERMs provides additional information as to how this class of ligands can elicit diverse biologic responses.

TL;DR: It is demonstrated that genistein and 17beta-estradiol have comparable anti-apoptotic properties in primary cortical neurons and that these properties are mediated through estrogen receptors.

TL;DR: The ability of a compound to selectively bind to a particular ER subtype can be species dependent, as shown by amino acids identified by crystallography as lining the ligand binding cavity among the three species.

TL;DR: A number of factors, including interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and prostaglandin E(2) (PGE(2)), which can stimulate aromatase activity, have now been identified.

TL;DR: Although absolute concentrations may differ for some hormones, radioimmunoassay and mass spectrometry can yield similar estimates of between subject differences in serum concentrations of most steroid sex hormones commonly measured in population studies.

TL;DR: Current evidence suggests this G-protein-coupled receptor-like protein is the long sought after MIS receptor mediating meiotic maturation of teleost oocytes, and the cloning strategy to isolate the MIS receptor gene from spotted seatrout ovaries is discussed.

TL;DR: The naturally occurring mutation in an AUUUA motif in the 3′UTR of hGRβ mRNA results not only in increased mRNA stability, but also in increased receptor protein expression, which may contribute to glucocorticoid resistance.

TL;DR: A number of observations in women, in experimental animals, and in isolated organ or cell systems using 17beta-estradiol, progesterone or glucocorticoids provide ample evidence for rapid intracellular metabolic responses to these steroids, mediated by their actions at the cellular plasma membrane.

TL;DR: This review summarizes data about non-genomic actions of testosterone on murine malaria, T cells and macrophages produced by the group during the last 15 years and tries to isolate testosterone surface receptors and to investigate a possible cross-talk of non- genomic testosterone signaling with other genotropic signaling pathways.

TL;DR: It is argued that B-ring modification predated steroid evolution: non-enzymatic oxidation of membrane sterols primarily results in 7-oxygenation.

TL;DR: Observations provide evidence for the existence of a steroid receptor fast-action complex, or SRFC, in caveolae in endothelial cells, where they are coupled via G(alpha i) to eNOS in a functional signaling module.

TL;DR: Investigation of the effect of prolonged application and rapid removal of this steroid on a traditional transmitter receptor in the brain lead to alterations in GABAR subunit composition that result in changes in the intrinsic channel properties of the receptor and behavioral excitability.

TL;DR: Using monoclonal antibodies specific for hER beta1, it is found that ER beta 2, beta 4 and beta 5 proteins are expressed in nuclei of human tissues including the ovary, placenta, testis and vas deferens.

TL;DR: Evidence is presented that 1 alpha,25(OH)(2)D(3) mediated rapid response and genomic response signal transduction pathways utilize differing shapes of ligand, both as agonists and antagonists.

TL;DR: A novel, non-transcriptional mechanism for ER signaling in human as well as in animal endothelial cells is described, showing that ER alpha can physically and functionally couple to the lipid kinase phosphatidylinositol 3-OH kinase (PI3K), which leads to activation of PI3K signaling cascade to Ser/Thr kinase Akt, which mediates several PI2K-dependent intracellular effects.

TL;DR: PgR636 and PgR1294 are optimal antibodies for IHC detection of PR in routine paraffin tissue blocks, indicating that the majority of the other antibodies tested were highly dependent on antigen retrieval.

TL;DR: These regulatory phenomena demonstrate that levels of the membrane form of the estrogen receptor are very dynamic, as upon estrogen treatment they rapidly round up and leave the substrates to which they are attached.

TL;DR: This review presents both pro and con findings of the role of leptin in reproduction, thereby demarking controversial areas that undoubtedly will be fertile ground for future investigation.

TL;DR: Findings indicate a richly complex yet coordinated steroid modulation of K(+) channel activity that serves to control the excitability of hypothalamic neurons involved in regulating the reproductive axis.

TL;DR: The findings show that beta androstenes and analogs protect the host from lethal infection by DNA or RNA viruses such as, herpesvirus type 2, coxsackievirus B4, influenza, and arthropod borne viruses and from parasites infections, i.e. Cryptosporidium parvum, and malaria.

TL;DR: Adding a 2- or 4-fluoro substituent to 16alpha-[18F]fluoroestradiol (FES), a positron emission tomography (PET) radiopharmaceutical used for estrogen receptor (ER) imaging, should prolong its blood circulation time, and thus, improve its localization in ER-rich target tissues.

TL;DR: It is demonstrated that response to 1α,25-(OH)2D3 and 24R,25-OH) 2D3 depends on osteoblast maturation state and suggest that specific and distinct membrane receptors are involved.

TL;DR: This study shows that Dex and RA have differential effects on the expression of the phenotypic markers and genes associated with osteoblast maturation.

TL;DR: The data indicate that B cells express neither mAR nor mER on their surfaces, in contrast to other major cells of the immune system such as T cells and macrophages.

TL;DR: Tributyltin inhibited 5alpha-reductase type 1 competitively whereas an irreversible inhibition was evident for the type 2 isoenzyme, and reductive brain 17beta-hydroxysteroid dehydrogenase activity was not inhibited by any butyltins.

TL;DR: The expression pattern of mAR and iAR in thymic T cells is compared with that of splenic T cells to support the view of a delicately balanced developmental regulation of iAR and mAR in T cells.

TL;DR: Findings indicate that the acute inhibitory effects of cortisol on PRL release occur through a nongenomic mechanism involving interactions with the plasma membrane and inhibition of both the Ca(2+) and cAMP signal transduction pathways.

TL;DR: The physiological function of non-genomic effects of aldosterone and estradiol is to shift the balance from net secretion to net absorption in a pluripotential epithelium to enhance the capacity for absorption while down-regulating the potential for secretion.