Showing papers in "The International Journal of Biochemistry & Cell Biology in 2018"

TL;DR: Current understanding of mitochondria-derived oxidative stress in the progression of NAFLD is updated and a vicious cycle of exacerbated mitochondrial dysfunction and increased hepatocellular oxidative damage may ultimately pave the way for hepatic inflammation and liver failure.

TL;DR: This review outlines how components of the ubiquitination systems act as oncogenes or tumor suppressors according to the nature of their substrates, and interrogates how the current knowledge of the differential roles of ubiquitinations in cancer lead to technical advances to inhibit or reactivate the components of this system accordingly.

TL;DR: SRRF can be used to retrieve super-resolution information from most common fluorescence microscopes, and is compatible with any fluorophore, including conventional fluorescent proteins such as GFP.

TL;DR: Insight into the structural, molecular, and biological framework driving the efficacy of these therapeutic strategies will provide a foundation for the refinement and development of novel and clinically tractable PP2A targeted therapies.

TL;DR: The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo, however, the diverse channelopathies associated with the known channels highlights their physiological importance.

TL;DR: An overview of systemic therapies currently recommended for the treatment of breast cancer bone metastases and emerging therapeutic targets are provided and key pathways dysregulated in breast cancer metastasis to bone are explored.

TL;DR: Key research is highlighted on microglia's role in neuronal plasticity across the lifespan, which may compromise the ability of the adult brain to fight infections and process cognitive information.

TL;DR: The data supported that HK2 promotes cisplatin resistance in ovarian cancer by enhancing drug-induced, ERK-mediated autophagy, and targeting HK2 may be a new therapeutic strategy to combat chemoresistance in ovariancancer.

TL;DR: The findings indicated that NIFK-AS1 inhibited the M2-like polarization of macrophages via targeting miR-146a, thereby reducing the estrogen-induced proliferation, migration and invasion of endometrial cancer cells.

TL;DR: The loss of αvβ6 integrin function in mice and humans leads to an altered immune response in lungs and skin, amelogenesis imperfecta, periodontal disease and, in some cases, alopecia, which makes it an attractive target for cancer imaging and for fibrosis and cancer therapy.

TL;DR: It is proposed that non-genetic inhibition is the dominant mechanism causing loss ofPP2A tumor suppressor function in cancer cells, possibly because these mechanisms do not elicit genomic instability associated with genetic loss of function of specific PP2A subunits.

TL;DR: TUG1 interacting with miR-144 contributed to proliferation, migration and tumorigenesis through activation of the JAK2/STAT3 pathway in HCC.

TL;DR: It is demonstrated that Mdivi-1 mitigates TBI-induced BBB disruption and cell death at least in part by a mechanism involving inhibiting autophagy dysfunction and mitophagy activation.

TL;DR: This review addresses the important roles of the CXCR4-CXCL12 axis in homeostasis, specially focusing in hematopoiesis, and provides a picture of C XCR4 as mediator of cancer cell spreading, and a view of the available CX CR4 antagonists in different cancer types.

TL;DR: HOTTIP is a potential oncogene in PTC and may serve as a therapeutic target for malignancies.

TL;DR: Adaptations to maternal conditions enable the fetus to survive, but at the cost of permanently changing its physiology and structure, which triggers fetal programming that increases predisposition to various pathological conditions in adult life.

TL;DR: The results show that ELF3 promotes cell growth and metastasis by regulating PI3K/Akt and ERK pathways in NSCLC and that it may be a promising new target for the treatment of NSCLc patients.

TL;DR: The mechanistic role of histone deacetylase inhibitors (HDACi) as potential immunomodulating agents to treat cancer is discussed and the current understanding of the use of HDACi in combination with various immunotherapeutic approaches, such as immunommodulating agents and cancer vaccines are addressed.

TL;DR: The results indicate the importance of miR-155-5p in cervical cancer cells and suggest a novel mechanism of hrHPV in promoting cervical lesions.

TL;DR: This work reviews mitochondrial copper homeostasis but also the impact of excessive mitochondrial copper in Wilson disease, a genetic disease characterized by dysfunctional copper excretion from the liver.

TL;DR: This study demonstrates that NRF2 promotes breast cancer progression by enhancing glycolysis through coactivation of HIF1α, implicating thatNRF2 is a potential molecular target for breast cancer treatment.

TL;DR: Although targeting mitochondrial oxidative stress with antioxidants has been demonstrated, clinical use has been hampered by several challenges, and development of new mitochondriotropic antioxidant agents based on dietary polyphenols has recently gained momentum.

TL;DR: This study identified a novel long noncoding RNA (lncRNA), which is downregulated by baicalein in a dose- and time-dependent manner in cervical cancer, and named this lncRNA as baicalsein down-regulated longnoncodingRNA (BDLNR).

TL;DR: LncRNA UCA1 suppressed pilocarpine-induced epilepsy in rat by inhibiting apoptosis of hippocampal neurons through miR-495/Nrf2-ARE pathway, and thereby inhibiting brain injury induced by seizure.

TL;DR: Currently used urinary biomarkers in the clinic and attempts that have been made to identify EV-derived biomarkers for urological cancers are reviewed and technical and methodological considerations towards their clinical implementation are discussed.

TL;DR: It is demonstrated that the Nod-like receptor protein 3 (NLRP3) inflammasome is activated by mitochondrial reactive oxygen species (mROS) during I/R injury via direct interactions between the inflammaome and thioredoxin-interacting protein (TXNIP).

TL;DR: The factors which have important role in chemoresistance and are associated with bone marrow microenvironment are highlighted to throw light toward developing more effective therapeutic strategies to eradicate cancer in the patients concerned.

TL;DR: It is shown that CBX4 is up-regulated in breast cancer and exerts oncogenic activities via miR-137-mediated activation of Notch1 signaling pathway, and that targeting CBX 4/miR- 137 axis may provide therapeutic potent in the treatment of breast cancer.

TL;DR: It is found that expression of BC200 was up-regulated in colon cancer tissues as compared with adjacent non-cancerous tissues and the BC200 level was positively correlated with advanced TNM stage.

TL;DR: The normal function and physiology of the spleen, the pathophysiological bases of splenomegaly and the commonly available therapeutic options are discussed and experimental systems are addressed to determine the regulatory mechanisms underlying splenomesgaly.