Ines C.M. Simoes

TL;DR: An update regarding the key roles of ROS-mitochondria cross talk in different fundamental physiological or pathological situations accompanying aging is provided, highlighting that mitochondrial ROS may be a decisive target in clinical practice.

TL;DR: Current understanding of mitochondria-derived oxidative stress in the progression of NAFLD is updated and a vicious cycle of exacerbated mitochondrial dysfunction and increased hepatocellular oxidative damage may ultimately pave the way for hepatic inflammation and liver failure.

TL;DR: An in silico alanine scanning mutagenesis protocol is refined, based on a residue-dependent dielectric constant version of the Molecular Mechanics/Poisson-Boltzmann Surface Area method, which allows for a better computational identification of hot spots, avoiding expensive and time-consuming experiments or thermodynamic integration/ free energy perturbation/ uBAR calculations.

TL;DR: The present review summarizes the current understanding of basic MAM biology, composition and function and discusses the possible role of MAM-resident oncogenes and tumor suppressors.

TL;DR: In this article, a review of the current understanding of NAFLD pathogenesis and clarifies whether mitochondrial dysfunction and reactive nitrogen species (RNS) are culprits or bystanders of NASH progression.