Showing papers in "Trends in Biochemical Sciences in 1976"

TL;DR: This "catabolite inactivation" in yeast is described and discussed and it is shown that glucose and its catabolites not only cause repression of enzyme synthesis in some organisms but also inactivation of certain enzymes.

TL;DR: This data indicates that cell recognition at the chemical level is influenced by several different mechanisms, including “self-consistency”, “cell reprograming” and “drug-drug interaction”.

TL;DR: The metabolic fate of pyrophosphate is usually considered to be its hydrolysis to orthophosphate, providing an additional driving force for biosynthesis, but this simplistic view must be modified in order to accommodate the growing number of energy-conserving reactions that involve pyroph phosphate.

TL;DR: Glycogen and starch may be synthesized on a protein backbone, with the protein forming an integral part of the macromolecular product.

TL;DR: It has become increasingly apparent that many functions of zinc in biology are very similar to those of the vitamins: it serves as a coenzyme.

TL;DR: The selectivity and mode of action of translation inhibitors is briefly discussed.

TL;DR: The interactions of ions with biological membranes play a significant role in such diverse phenomena as pinocytosis, cell division and energization of mitochondrial membranes.

TL;DR: The availability of unlimited amounts of desiccated, ametabolic, yet viable gastrulae has caused the brine shrimp, Artemia salina, to become increasingly popular as a subject for developmental biochemists.

TL;DR: Multisite phosphorylation of proteins may be a common mechanism for greatly increasing the potential for regulation of their function.

TL;DR: A good half century after the classic experiments of Gorter and Grendel, the arguments in favour of the lipid bilayer concept seem to be stronger than ever.

TL;DR: An attempt to understand the mechanism by which a structural transition in the membrane lipids of a bacterial cytoplasmic membrane affects the transport functions of the membrane.

TL;DR: Reconstitution experiments indicate that the glycoprotein helps maintain normal cell shape, adhesion, and contact inhibition of movement in fibroblast cells.

TL;DR: Tungsten has proved to be a biologically active metal, having been found to beA component of the formate dehydrogenases of Clostridium thermoaceticum and C. formicoaceticom.

TL;DR: The family of biotin-dependent enzymes offers an opportunity for the study of evolutionary pathways among enzymes, and this group of enzymes exhibits a great variety of structural features.

TL;DR: Solutes are carried across eukaryotic plasma membranes by oligomeric glycoproteins which span the cell membranes and conduct transport by undergoing conformational changes.

TL;DR: ATP-driven ion pumps are used by cells to generate ion gradients at the expense of ATP hydrolysis or to generate ATP at the cost of an ion gradient.

TL;DR: The use of dolichol pyrophosphate in place of the commoner nucleoside diphosphate as the sugar carrier may be because the former is more compatible with the hydrophobic environment of the membrane where the glycoprotein synthesis occurs.

TL;DR: The formation of the yeast primary septum, a disk composed of chitin, is studied as a model for morphogenesis and appears to take place by localized activation of a zymogen of Chitin synthetase that is attached to the plasma membrane.

TL;DR: Electric eel acetylcholinesterase is a complex molecular structure in which a multisubunit head bearing the active sites of the enzyme is attached to an elongated tail.

TL;DR: Rats will press a lever to activate specific central catecholamine-releasing pathways by means of an implanted electrode, and a dopamine system arising from the ventral mid-brain and the locus coeruleus noradrenalin system may mediate different aspects of the organism's response to rewarding stimuli.

TL;DR: There are now several lines of evidence that suggest that the predominant assimilatory route for ammonia derived from external ammonia, nitrite or dinitrogen, is via glutamine synthetase and glutamate synthase, and that glutamate dehydrogenase is only involved in relatively few situations.

TL;DR: The activity of protein phosphatase itself may be regulated and it is suggested that this enzyme is the target for the action of insulin in stimulating glycogen and lipid synthesis.

TL;DR: Patients lacking the necessary cell surface receptor, Familial Hypercholesterolemia homozygotes, have a defective uptake of low density lipoprotein, consequently impaired regulation of cholesterol synthesis and develop hypercholesterolesmia and fulminant atherosclerosis.