Book ChapterDOI
16 – Oxidative Stress in the Nervous System
Gerald Cohen
- pp 383-402
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The article was published on 1985-01-01. It has received 73 citations till now. The article focuses on the topics: Nervous system & Oxidative stress.read more
Citations
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Free radical tissue damage: protective role of antioxidant nutrients.
L J Machlin,Adrianne Bendich +1 more
TL;DR: Considering the growing interest in free radical biology and the lack of effective therapies for many of the chronic diseases, the usefulness of essential, safe nutrients in protecting against the adverse effects of oxidative injury warrants further study.
Journal ArticleDOI
Quinone chemistry and toxicity
Journal ArticleDOI
Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries
TL;DR: The inadequacy of current conventional methods to prevent tyrosinase action encourages researchers to seek new potent tyrosine inhibitors for food and cosmetics.
Journal ArticleDOI
Oxygen free radicals and Parkinson's disease
James D. Adams,Ifeoma N. Odunze +1 more
TL;DR: Iron, lipid peroxidation, peroxidase, catalase, superoxide dismutase, and glutathione levels in the brain, and various theories of induction of Parkinson's disease are discussed in relation to the possible involvement of oxygen radicals.
Journal ArticleDOI
Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration
TL;DR: The results suggest that catecholamines can cause toxicity not only by inducing an oxidative stress state but also possibly through direct interaction with the mitochondrial electron transport system.
References
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Journal ArticleDOI
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more
TL;DR: It is proposed that the autoxidation of epinephrine proceeds by at least two distinct pathways, only one of which is a free radical chain reaction involving O2- and hence inhibitable by superoxide dismutase.
Journal ArticleDOI
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
TL;DR: It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.
Journal ArticleDOI
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
TL;DR: The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan.
Journal Article
Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
TL;DR: 6-hydroxydopamine and 2,4,5-trihydroxyphenylalanine kill cells through the production of H2O2, O2[unknown], and OH·, while for dopamine and dopa the reaction of quinone oxidation products with nucleophiles probably also contributes to their cytotoxicity.
Journal ArticleDOI
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents.
Gerald Cohen,Richard E. Heikkila +1 more
TL;DR: The results point to a reaction between H2O2 and O2- (Haber-Weiss reaction) as a major source of the ·OH radicals and to a combined action of blocking ·OH formation as well as accelerating its removal.
Related Papers (5)
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Hara P. Misra,Irwin Fridovich +1 more