18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer: Determination of Tumor Proliferative Activity and Comparison with Glycolytic Activity as Measured by 18F-FDG Positron Emission Tomography/Computed Tomography Imaging.
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TLDR
Different tumor segmentation techniques yielded varying degrees of correlation in FTV between FLT and FDG-PET images, suggesting FLT imaging may have a different meaning in determining tumor biology and prognosis.Abstract:
Objective:
This phase-I imaging study examined the imaging characteristic of 3’-deoxy-3’-(18F)-fluorothymidine (18F-FLT) positron emission tomography (PET) in patients with pancreatic cancer and comparisons were made with (18F)-fluorodeoxyglucose (18F-FDG). The ultimate aim was to develop a molecular imaging tool that could better define the biologic characteristics of pancreas cancer, and to identify the patients who could potentially benefit from surgical resection who were deemed inoperable by conventional means of staging.read more
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Current clinical status of 18 F-FLT PET or PET/CT in digestive and abdominal organ oncology
Masatoyo Nakajo,Yoriko Kajiya,Megumi Jinguji,Yoshiaki Nakabeppu,Masayuki Nakajo,Tohru Nihara,Takashi Yoshiura +6 more
TL;DR: The results of this review show that although 18F-FLT uptake is lower in most cases of digestive and abdominal malignancies compared with18F-FDG uptake, 18F -FLT-PET can be used to detect primary tumors and will be a powerful tool for monitoring response to treatment and provide prognostic information in digestive and abdomen oncology.
Journal ArticleDOI
The clinical application of 18 F-FDG PET/CT in pancreatic cancer: a narrative review
Yongzhu Pu,Chun Wang,Zhao Sheng,Ran Xie,Lei Zhao,Kun Li,Yang Conghui,Rui Zhang,Yadong Tian,Lixian Tan,Jindan Li,Shujuan Li,Long Chen,Sun Hua +13 more
TL;DR: PET/CT can determine the metabolic capacity and anatomical position of pancreatic tumor cells in the body accurately diagnose the patient's condition and tumor location and plays a vital role in early diagnosis and accurate staging, predicts survival and pancreatic cancer recurrence.
Journal ArticleDOI
Pilot study on the impact of F18-labeled thymidine PET/CT on gross tumor volume identification and definition for pancreatic cancer.
Jennifer Pretz,Michael A. Blake,Joseph H. Killoran,Harvey J. Mamon,Jennifer Y. Wo,Andrew X. Zhu,Theodore S. Hong +6 more
TL;DR: FLT-PET improves interobserver concordance in GTV definition in patients with FLT-avid tumors, and further studies will focus on verification of these findings, pathologic verification of the FLt-PET signal, and optimization of the FlT- PET signal threshold for autosegmentation.
Journal ArticleDOI
The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis
TL;DR: 18F-FDG PET/CT was found to be a reliable detection method in recurrent pancreatic tumor.
Journal ArticleDOI
PET Imaging in Pancreatic Cancer
Xiaohui Wang,Yumin Li,Sift Desk +2 more
TL;DR: Current PET molecular imaging tracers or probes for pancreatic cancer detection are summarized, and a perspective of the future trend of Pancreatic cancer target-specific probes in the clinic is also presented.
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Analysis of Microarray Data Using Z Score Transformation
TL;DR: It is concluded that the Z score transformation normalization method accompanied by either Z ratios or Z tests for significance estimates offers a useful method for the basic analysis of microarray data.
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Imaging Proliferation in Brain Tumors with 18F-FLT PET: Comparison with 18F-FDG
Wei Chen,Timothy F. Cloughesy,Nirav Kamdar,Nagichettiar Satyamurthy,Marvin Bergsneider,Linda M. Liau,Paul S. Mischel,Johannes Czernin,Michael E. Phelps,Daniel H.S. Silverman +9 more
TL;DR: Thirty-minute PET of brain gliomas 5 min after injection was more sensitive than (18)F-FDG to image recurrent high-grade tumors, correlated better with Ki-67 values, and was a more powerful predictor of tumor progression and survival.
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Imaging Proliferation in Lung Tumors with PET: 18F-FLT Versus 18F-FDG
Andreas K. Buck,G. Halter,Holger Schirrmeister,Jörg Kotzerke,Imke Wurziger,Gerhard Glatting,Torsten Mattfeldt,Bernd Neumaier,Sven N. Reske,Martin Hetzel +9 more
TL;DR: F-FLT uptake correlates better with proliferation of lung tumors than does uptake of (18)F-FDG and might be more useful as a selective biomarker for tumor proliferation.
Journal ArticleDOI
Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods.
Laura M. Kenny,David M. Vigushin,Adil Al-Nahhas,Safiye Osman,Sajinder K. Luthra,Sami Shousha,R. Charles Coombes,Eric O. Aboagye +7 more
TL;DR: It is concluded that [18F]FLT-positron emission tomography is a promising clinical tool for imaging cellular proliferation in breast cancer, and is most predictive when analyzed by graphical and spectral methods.
Journal ArticleDOI
18F-FDG PET for Mediastinal Staging of Lung Cancer: Which SUV Threshold Makes Sense?
Dirk Hellwig,Thomas P Graeter,Dieter Ukena,Andreas Groeschel,Gerhard W. Sybrecht,Hans-Joachim Schaefers,Carl-Martin Kirsch +6 more
TL;DR: For mediastinal staging, the choice of an SUV of 2.5 as the threshold is justified because FNR + FPR is minimized, and the resulting high negative predictive value of 96% allows the omission of mediastinoscopy in patients with negative mediastsinal findings on 18F-FDG PET images.