1H-NMR study of gramicidin A transmembrane ion channel: Head-to-head right-handed, single-stranded helices
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TLDR
Analysis of nuclear Overhauser effects, spin‐spin couplings and solvent accessibility of NH groups show that the conformation of the Na+ complex of gramicidin A in detergent micelles is an N‐terminal to N‐ terminal (head‐to‐head) dimer formed by two right‐handed, single‐stranded β6.3 helices, differing from Urry's structure by handedness of the helices.About:
This article is published in FEBS Letters.The article was published on 1985-07-08 and is currently open access. It has received 290 citations till now. The article focuses on the topics: Nuclear magnetic resonance spectroscopy & Nuclear Overhauser effect.read more
Citations
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HOLE: a program for the analysis of the pore dimensions of ion channel structural models.
TL;DR: A method (HOLE) that allows the analysis of the dimensions of the pore running through a structural model of an ion channel is presented and can be used to predict the conductance of channels using a simple empirically corrected ohmic model.
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The pore dimensions of gramicidin A.
TL;DR: A new method is developed to analyze and display the pore dimensions of ion channels using two x-ray crystal structures of gramicidin that adopt distinct antiparallel double helical dimer conformations and a nuclear magnetic resonance (NMR) structure for the beta6.3 NH2-terminal to NH2 -terminal dimer.
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Et tu, Grotthuss! and other unfinished stories.
TL;DR: The classical Grotthuss model has been recently questioned and new mechanisms and ideas regarding proton transfer are briefly discussed and some of the questions that need to be addressed in the near future are discussed.
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Theoretical and computational models of biological ion channels
TL;DR: The goal of this review is to establish a broad and rigorous theoretical framework to describe ion permeation through biological channels on the basis of the statistical mechanical projection-operator formalism of Mori and Zwanzig.
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The condensing effect of cholesterol in lipid bilayers.
TL;DR: The condensing effect of cholesterol on phospholipid bilayers was systematically investigated for saturated and unsaturated chains, as a function of cholesterol concentration, using X-ray lamellar diffraction to measure the phosphate-to-phosphate distances.
References
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Energy parameters in polypeptides. VII. Geometric parameters, partial atomic charges, nonbonded interactions, hydrogen bond interactions, and intrinsic torsional potentials for the naturally occurring amino acids
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Energy parameters in polypeptides. 9. Updating of geometrical parameters, nonbonded interactions, and hydrogen bond interactions for the naturally occurring amino acids
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The Gramicidin A Transmembrane Channel: A Proposed π(L,D) Helix
TL;DR: A lipophilic, left-handed helical structure is proposed for gramicidin A in which the C-O bonds alternately point toward the amino and carboxyl ends; it is a hybrid of the 4.314 and 4.416 helices.
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Sequential resonance assignments as a basis for determination of spatial protein structures by high resolution proton nuclear magnetic resonance
TL;DR: A general scheme that relies on experimental observation by two-dimensional nuclear magnetic resonance techniques of complete throughbond and through-space proton-proton connectivity maps to obtain sequential resonance assignments for the individual residues in the amino acid sequence is proposed.
Journal ArticleDOI
The conformation of gramicidin A.
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