2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism
TLDR
Exposure to CW MW radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss, and learning and spatial memory deficit which increases with the increased duration of MW exposure is correlated with a decrease in hippocampal subfield neuronal arborization and dendritic spines.About:
This article is published in Toxicological Sciences.The article was published on 2015-09-22 and is currently open access. It has received 38 citations till now. The article focuses on the topics: Morris water navigation task & Hippocampal formation.read more
Citations
More filters
Journal ArticleDOI
Recent advances in the effects of microwave radiation on brains.
TL;DR: Recent studies that have explored the effects of microwave radiation on the brain, especially the hippocampus are reviewed, including analyses of epidemiology, morphology, electroencephalograms, learning and memory abilities and the mechanisms underlying brain dysfunction.
Journal ArticleDOI
Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects
TL;DR: This review can serve as a platform for researchers to understand the mechanism and interactions of microwave radiation with biological systems, the present scenario, and prospects for future studies on the effect of microwaves on the brain.
Journal ArticleDOI
From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.
TL;DR: 2.45 GHz MW radiation exposure induced local stress suppresses signaling mechanism(s) of hippocampal memory formation in adult male mice, leading to slow learning and significantly increased number of working and reference memory errors in radial maze task.
Journal ArticleDOI
Long term exposure to cell phone frequencies (900 and 1800 MHz) induces apoptosis, mitochondrial oxidative stress and TRPV1 channel activation in the hippocampus and dorsal root ganglion of rats.
TL;DR: Exposure to 900 and 1800 MHz EMR may induce a dose-associated, TRPV1-mediated stress response, and mitochondrial oxidative stress, programmed cell death and Ca2+ entry pathway through TRPVs activation in the HIPPON and DRGN of rats were increased.
References
More filters
Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
Journal ArticleDOI
Developments of a water-maze procedure for studying spatial learning in the rat
TL;DR: Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described, suggesting that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.
Journal ArticleDOI
Morris water maze: procedures for assessing spatial and related forms of learning and memory
TL;DR: The Morris water maze has proven to be a robust and reliable test that is strongly correlated with hippocampal synaptic plasticity and NMDA receptor function and trial-dependent, latent and discrimination learning can be assessed using modifications of the basic protocol.