Journal ArticleDOI
A 2H solid-state NMR spectroscopic investigation of biomimetic bicelles containing cholesterol and polyunsaturated phosphatidylcholine.
TLDR
It is demonstrated that the addition of Tm3+ to magnetically aligned DMPC/DMPC-d54/PLiPC/DHPC bilayers doubles the quadrupolar splittings, indicating that this unique bicelle system can be aligned with the bilayer normal parallel to the static magnetic field.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 2004-11-01. It has received 36 citations till now. The article focuses on the topics: Model lipid bilayer.read more
Citations
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Journal ArticleDOI
Current Applications of Bicelles in NMR Studies of Membrane-Associated Amphiphiles and Proteins†,‡
TL;DR: This review covers current trends in studies of membrane amphiphiles and membrane proteins using both fast tumbling bicelles and magnetically aligned bicelle media for both solution state and solid state NMR.
Journal ArticleDOI
Cholesterol as a co-solvent and a ligand for membrane proteins
TL;DR: A brief overview of cholesterol‐protein interactions is provided and a perspective on how and why binding of cholesterol to APP and its C99 domain (β‐CTF) promotes the amyloidogenic pathway, which is closely related to the etiology of Alzheimer's disease is offered.
Journal ArticleDOI
When detergent meets bilayer: birth and coming of age of lipid bicelles.
TL;DR: An introduction to the properties of lipid bicelle phases with an emphasis on NMR experimental measurements is given and some of the most exciting recent applications of bicelles in the structural and dynamic studies of membrane proteins are discussed.
Journal ArticleDOI
Comprehensive examination of mesophases formed by DMPC and DHPC mixtures.
Thad A. Harroun,Martin R. Koslowsky,Mu-Ping Nieh,Charles-François de Lannoy,V. A. Raghunathan,John Katsaras +5 more
TL;DR: Using polarized light microscopy and small-angle neutron scattering, phase diagrams of DMPC/DHPC mixtures at molar ratios of 2, 3.2, and 5 have been determined and a chiral nematic phase made up of worm-like micelles was observed.
Journal ArticleDOI
Activity of essential phospholipids (EPL) from soybean in liver diseases
TL;DR: The available studies characterize EPL as evidence-based medicine, although further long-term controlled clinical trials are required to precisely determine its benefit for alleviating symptoms, improving well-being, inducing histological changes and slowing the progression of liver disease.
References
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Journal ArticleDOI
Cholesterol and the cell membrane.
TL;DR: Recent studies concerning cholesterol, its behavior and its roles in cell growth provide important new clues to the role of this fascinating molecule in normal and pathological states.
Book
Spin Labeling: Theory And Applications
TL;DR: This special topics volume represents a complete update on new theoretical aspects and applications of the spin-label method and includes an IBM-compatible diskette supplied by David Schneider and Jack Freed which contains fast, accurate, ready-to-use software for slow-motion simulations.
Journal ArticleDOI
Cholesterol interactions with phospholipids in membranes.
TL;DR: This review is mainly focused on two of the major classes of membrane phospholipids in eukaryotic organisms, sphingomyelins and phosphatidylcholines, and the synthesis and distribution in the cell of these lipids, how they are believed to interact with each other, and what cellular consequences such interactions may have.
Journal ArticleDOI
MOLECULAR BASIS FOR MEMBRANE PHOSPHOLIPID DIVERSITY: Why Are There So Many Lipids?
TL;DR: The wide range of processes in which specific involvement of phospholipids has been documented explains the need for diversity inospholipid structure and why there are so many membrane lipids.
Related Papers (5)
Characterization of magnetically orientable bilayers in mixtures of dihexanoylphosphatidylcholine and dimyristoylphosphatidylcholine by solid-state NMR.
Charles R. Sanders,J.P. Schwonek +1 more