Journal ArticleDOI
Cholesterol interactions with phospholipids in membranes.
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TLDR
This review is mainly focused on two of the major classes of membrane phospholipids in eukaryotic organisms, sphingomyelins and phosphatidylcholines, and the synthesis and distribution in the cell of these lipids, how they are believed to interact with each other, and what cellular consequences such interactions may have.About:
This article is published in Progress in Lipid Research.The article was published on 2002-01-01. It has received 1016 citations till now. The article focuses on the topics: Membrane lipids & Biological membrane.read more
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Model systems, lipid rafts, and cell membranes.
Kai Simons,Winchil L.C. Vaz +1 more
TL;DR: This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what isknown of domain formation in cell membranes.
Journal ArticleDOI
Lipid Rafts: Elusive or Illusive?
TL;DR: There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids, and it seems that a definitive proof of raft existence has yet to be obtained.
Journal ArticleDOI
The state of lipid rafts: from model membranes to cells.
TL;DR: Despite extensive work, the basis for raft formation in cell membranes and the size of rafts and their stability are all uncertain and recent work converges on very small rafts <10 nm in diameter that may enlarge and stabilize when their constituents are cross-linked.
Journal ArticleDOI
Molecular machinery for non-vesicular trafficking of ceramide
Kentaro Hanada,Keigo Kumagai,Satoshi Yasuda,Yukiko Miura,Miyuki Kawano,Masayoshi Fukasawa,Masahiro Nishijima +6 more
TL;DR: It is concluded that CERT mediates the intracellular trafficking of ceramide in a non-vesicular manner.
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Antimicrobial activity of
TL;DR: A method using scanning electron microscope to study the morphology of the bacterial and fungal microbes and thus determining antimicrobial activity is presented in the chapter.
References
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Journal ArticleDOI
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
Book
The Hydrophobic Effect: Formation of Micelles and Biological Membranes
TL;DR: In this article, the authors discuss the properties of water molecules and their relationship with common soluble proteins, such as membrane proteins and membrane membrane proteins, as well as the effect of temperature on their properties.
Journal ArticleDOI
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Deborah A. Brown,John K. Rose +1 more
TL;DR: It is shown that a protein with a glycosylphosphatidyl inositol (GPI) anchor can be recovered from lysates of epithelial cells in a low density, detergent-insoluble form, supporting the model proposed by Simons and colleagues for sorting of certain membrane proteins to the apical surface after intracellular association with glycosphingolipids.
Journal ArticleDOI
Functions of lipid rafts in biological membranes.
Deborah A. Brown,Erwin London +1 more
TL;DR: The relationship between detergent-resistant membranes, rafts, caveolae, and low-density plasma membrane fragments, and possible functions of lipid rafts in membranes are discussed.
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Biochemistry of lipids, lipoproteins, and membranes
Dennis E. Vance,Jean E. Vance +1 more
TL;DR: This chapter discusses the physical properties and functional Roles of Lipids in Membranes, as well as the Dynamics of Lipoprotein Transport in the Circulatory System.