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A case of malignant cerebral infarction associated with COVID-19 infection.

TLDR
A case of a 46-year-old healthcare worker with COVID-19 who developed malignant cerebral infarction requiring emergency decompressive craniectomy is described, illustrating the neurosurgical implications associated with inflammatory and pro-coagulopathic derangements in CO VID-19 disease.
Abstract
Stroke as a presenting feature of COVID-19 infection is being increasingly recognized. We describe a case of a 46-year-old healthcare worker with COVID-19 who developed malignant cerebral infarction requiring emergency decompressive craniectomy. This case illustrates the neurosurgical implications associated with inflammatory and pro-coagulopathic derangements in COVID-19 disease.

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Malignant cerebral infarction associated with COVID-19 in a child.

TL;DR: A case of a child with serological evidence of SARS-CoV-2 infection whose onset was a massive right cerebral artery ischemia that led to a malignant cerebral infarction was presented in this article.
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Case Report: Decompressive Craniectomy for COVID-19 Malignant Cerebral Artery Infarction. Is Surgery a Good Option?

TL;DR: In this paper, a 39-year-old female with no major risk factors for cerebrovascular disease, apart from oral contraception, and mild COVID-19 symptoms suffered from left hemispheric syndrome was treated with decompressive craniectomy.
Posted ContentDOI

Vascular Thrombosis in COVID-19: A Potential Association with Antiphospholipid Antibodies

TL;DR: Analysis of pooled patients revealed that aPL were significantly more frequent in COVID-19 patients with stroke than stroke patients in the general population, and these antibodies may be a key mechanism of thrombosis in CO VID-19.
Journal ArticleDOI

Does covid-19 impair endogenous neurogenesis?

TL;DR: In this article , SARS-CoV-2 infection may impair endogenous neural stem cell activity, which may contribute to reduction in brain size and/or neurodegenerative processes.
Journal ArticleDOI

Acute confusional state as a prognostic sign of COVID-19 large-vessel occlusion (LVO).

TL;DR: In this article, the authors presented a unique case of COVID-19 LVO manifesting as an acute confusional state in an elderly man in April 2020, where CT angiography revealed 'de novo' occlusions of the left internal carotid artery and proximal right vertebral artery, effectively blocking anterior and posterior circulations.
References
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Journal ArticleDOI

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
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Neurologic Features in Severe SARS-CoV-2 Infection.

TL;DR: Neurologic Features in SARS-CoV-2 Infection In a consecutive series of 64 patients with Covid-19 and ARDS, 58 of whom underwent neurologic examination, severe agitation and corticospinal signs were found.
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Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.

TL;DR: At least a subset of sustained, severe COVID-19 may define a type of catastrophic microvascular injury syndrome mediated by activation of complement pathways and an associated procoagulant state, and could suggest targets for specific intervention.
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The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
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Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.

TL;DR: Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.
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