scispace - formally typeset
Journal ArticleDOI

A cellular mechanism for cortical associations: an organizing principle for the cerebral cortex.

Matthew E. Larkum
- 01 Mar 2013 - 
- Vol. 36, Iss: 3, pp 141-151
Reads0
Chats0
TLDR
A hypothesis is presented that the extraordinary performance of the cortex derives from an associative mechanism built in at the cellular level to the basic cortical neuronal unit: the pyramidal cell.
About
This article is published in Trends in Neurosciences.The article was published on 2013-03-01. It has received 631 citations till now. The article focuses on the topics: Cortex (anatomy) & Neocortex.

read more

Citations
More filters
Journal ArticleDOI

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits

TL;DR: Current understanding of neocortical interneuron diversity and the properties that distinguish cell types are reviewed and it is illustrated how recent advances in the field have shed light onto the mechanisms by which GABAergic inhibition contributes to network operations.
Journal ArticleDOI

Interoceptive predictions in the brain

TL;DR: The Embodied Predictive Interoception Coding model is introduced, which integrates an anatomical model of corticocortical connections with Bayesian active inference principles, to propose that agranular visceromotor cortices contribute to interoception by issuing interoceptive predictions.
Journal ArticleDOI

Neural correlates of consciousness: progress and problems

TL;DR: Recent findings showing that the anatomical neural correlates of consciousness are primarily localized to a posterior cortical hot zone that includes sensory areas, rather than to a fronto-parietal network involved in task monitoring and reporting are described.
Journal ArticleDOI

A disinhibitory circuit mediates motor integration in the somatosensory cortex

TL;DR: This work used optogenetics to examine the long-range inputs from vM1 to the various neuronal elements in S1 and found that S1-projecting vM2 pyramidal neurons strongly recruited vasointestinal peptide (VIP)-expressing GABAergic interneurons, a subset of serotonin receptor–expressing interneerons.
References
More filters
Journal ArticleDOI

Distributed Hierarchical Processing in the Primate Cerebral Cortex

TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
Journal ArticleDOI

Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects.

TL;DR: Results suggest that rather than being exclusively feedforward phenomena, nonclassical surround effects in the visual cortex may also result from cortico-cortical feedback as a consequence of the visual system using an efficient hierarchical strategy for encoding natural images.
Journal ArticleDOI

Dynamic predictions: Oscillations and synchrony in top–down processing

TL;DR: It is argued that coherence among subthreshold membrane potential fluctuations could be exploited to express selective functional relationships during states of expectancy or attention, and these dynamic patterns could allow the grouping and selection of distributed neuronal responses for further processing.
Journal ArticleDOI

Interneurons of the neocortical inhibitory system.

TL;DR: This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.
Journal ArticleDOI

Molecular and cellular mechanisms of general anaesthesia

TL;DR: It is now clear that anaesthetics act directly on proteins rather than on lipids, with potentiation of postsynaptic inhibitory channel activity best fitting the pharmacological profile observed in general anaesthesia.
Related Papers (5)