Journal ArticleDOI
A clinical and epidemiological study of Loxosceles spider envenoming in Santa Catarina, Brazil
Ulisses Marion Sezerino,Marlene Zannin,Luciano Kowlaski Coelho,João Gonçalves,Margareth Grando,Suely Grossemann Mattosinho,João Luiz Costa Cardoso,Vera Regina von Eickstedt,F.O.S. França,Katia C. Barbaro,Hui Wen Fan +10 more
TLDR
A clinical and epidemiological study of 267 cases of envenomation by Loxosceles spp.Abstract:
A clinical and epidemiological study of 267 cases of envenomation by Loxosceles spp. (loxoscelism), notified to Centro de Informacoes Toxicologicas de Florianopolis (Santa Catarina State, Brazil), was conducted between January 1985 and December 1995. Most of the incidents occurred along the coast of the mid-southern region of the state, during the warmest months. L. laeta and L. intermedia were identified as the causative agents. Cutaneous loxoscelism was clinically diagnosed in 232 (86·9%) patients with local pain (86·5%), oedema (80·5%), hyperaemia (79·8%) and necrosis (56·9%). Cutaneous-visceral loxoscelism was detected in 35 patients (13·1%) with intravascular haemolysis, manifested by jaundice (68·6%), oliguria (45·7%), dark urine (28·6%), haemorrhage (25·7%), anuria (8·6%) and shock (2·9%), besides the cutaneous effects. Specific antivenom was given to 125 patients (46·8%) and only 8(6·5%) had mild reactions. Acute renal failure was observed in 17 cases (6·4%); 4 patients (1·5%) died, all of whom were children under 14 years old.read more
Citations
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Journal ArticleDOI
The contrasting characteristics of acute kidney injury in developed and developing countries
TL;DR: Differences and similarities in the condition between developed and developing areas are identified, the practical implications of the identified differences are analyzed, and evidence-based recommendations for study and management are made.
Journal ArticleDOI
Brown spiders and loxoscelism
Paulo Henrique da Silva,Rafael Bertoni da Silveira,Marcia Helena Appel,Oldemir C. Mangili,Waldemiro Gremski,Silvio Sanches Veiga +5 more
TL;DR: The biology and epidemiology of the brown spider, the histopathology of envenomation and the immunogenicity of Loxosceles venom are reviewed, as are the clinical features, diagnosis and therapy of brown spider bites.
Journal ArticleDOI
Bites of brown recluse spiders and suspected necrotic arachnidism.
TL;DR: Although much has been published about the pathophysiology and treatment of necrotic spider bites, therapeutic interventions continue without evidence-based justification.
Journal ArticleDOI
Loxoscelism: Old obstacles, new directions
TL;DR: Animal model studies suggest the potential value of specific antivenom to decrease lesion size and limit systemic illness even when such administration is delayed.
Journal ArticleDOI
Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas.
Katia C. Barbaro,Irene Knysak,Rosana Martins,Chris Hogan,Chris Hogan,Chris Hogan,Kenneth D. Winkel +6 more
TL;DR: As Brazilian commercial antivenoms are able to neutralize the dermonecrosis induced by Loxosceles venoms of diverse geographical origin, clinical studies should be undertaken on the potential for a single global LoxOSceles antivenom.
References
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Book
Handbook of Clinical Toxicology of Animal Venoms and Poisons
TL;DR: Venomous and Poisonous animals-A Biologist's View, J. Meier Poisonous and Venomous Animals-The Physician's View; and Clinical Toxicology of Spider Bites and Antivenom Therapy.
Journal ArticleDOI
Brown recluse spider bites. A comparison of early surgical excision versus dapsone and delayed surgical excision.
TL;DR: Pretreatment with dapsone not only reduced surgical complications but also improved the outcome of patients bitten by the brown recluse spider.
Journal ArticleDOI
Spiders in Brazil.
TL;DR: Detailed information on their habitat, behaviour and venom quantity, symptomatology of human accidents and epidemiology is given and recommendations are made for the prevention of accidents.
Journal ArticleDOI
The diagnosis and treatment of brown recluse spider bites.
Riley S. Rees,Riley S. Rees,Douglas S Campbell,Erik Rieger,Erik Rieger,Lloyd E. King,Lloyd E. King +6 more
TL;DR: The experience with 95 patients who carried the diagnosis of brown recluse spider bite between 1983 and 1986 was reviewed and a reference group of 17 with confirmed bites was identified, but historical data were incomplete and no conclusions could be drawn.
Journal Article
Incorporation of a 35-kilodalton purified protein from Loxosceles intermedia spider venom transforms human erythrocytes into activators of autologous complement alternative pathway.
Denise V. Tambourgi,Fábio Carlos Magnoli,V. R. D. Von Eickstedt,Z. C. Benedetti,Vera L. Petricevich,W. Dias da Silva +5 more
TL;DR: The data suggest that the C system mediates the lysis of human erythrocytes and, by extension, of other cell types able to incorporate the lytic factor of Loxosceles venoms on their cell surfaces.