Journal ArticleDOI
A comparative study between platelet-rich plasma and platelet-poor plasma effects on angiogenesis
Minoo Shahidi,Mousa Vatanmakanian,Masoumeh Kourosh Arami,Fatemeh Shirazi,Najibeh Esmaeili,Samaneh Hydarporian,Soudeh Jafari +6 more
TLDR
The findings indicated significant effect of PRP and PPP on VEGFR2 and CD34 expression by human umbilical vein endothelial cells, which was greater in latter.Abstract:
Platelet-rich plasma (PRP) has been established as an autologous source for therapeutic angiogenesis. The purpose of this study was to evaluate PRP angiogenic effects compared to platelet-poor plasma (PPP) in vitro and in vivo. The effects of PRP on vascular endothelial growth factor receptor-2 (VEGFR2) and CD34 expression were evaluated using real-time PCR, flow cytometry, western blot, immunocytochemistry and pathological study, as were carried out in both human umbilical endothelial cell culture and rat skin. Our findings indicated significant effect of PRP and PPP on VEGFR2 and CD34 expression by human umbilical vein endothelial cells, which was greater in latter. These effects, however, were confirmed by demonstrating an earlier angiogenic effect of PPP in vivo when compared to PRP. The findings of the present study as the first comparative study of PRP versus PPP are novel. Nevertheless, further studies are needed to clarify the underlying mechanism of these findings to improve the therapeutic effects of PRP and PPP.read more
Citations
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Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration
TL;DR: This review focuses on the contribution of blood-derived products on repair/regeneration of damaged skeletal muscle, paying particular attention to the potential cellular targets and molecular mechanisms through which these products may exert their beneficial effects.
Journal ArticleDOI
Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance
Hassan Yousefi,Mousa Vatanmakanian,Mojdeh Mahdiannasser,Ladan Mashouri,Nikhilesh V. Alahari,Mohammad Rafiee Monjezi,Shahrzad Ilbeigi,Suresh K. Alahari +7 more
TL;DR: In this paper, the authors examined the role of integrins in breast cancer and found that integrin binding to extracellular ligands promotes the growth of metastatic cells.
Journal ArticleDOI
Recent advances in understanding primary ovarian insufficiency.
TL;DR: The goal is to familiarize the multidisciplinary readers of the F1000 platform with the strides made in the field of reproductive medicine that hold both preventative and therapeutic implications for those women who are at risk for or who have POI.
Journal ArticleDOI
Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction.
TL;DR: As a minimally invasive method, PRP administration to the distal anterior vaginal wall may improve female sexuality with high satisfaction.
Journal ArticleDOI
Similar effect of ultrasound-guided platelet-rich plasma versus platelet-poor plasma injections for chronic plantar fasciitis.
Michael-Alexander Malahias,Andreas F. Mavrogenis,Vasilios S. Nikolaou,Panayiotis D. Megaloikonomos,Stamatios T. Kazas,Efstathios Chronopoulos,George C. Babis +6 more
TL;DR: A single US-guided PRP injection yields similar results with PPP injection in patients with chronic plantar fasciitis, and both treatments provide significant improvement at 3 and 6-month follow-up after the injection.
References
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Journal ArticleDOI
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.
Julie Gavard,J. Silvio Gutkind +1 more
TL;DR: Evidence is provided of a novel signalling pathway by which VEGF stimulation promotes the rapid endocytosis of a key endothelial cell adhesion molecule, VE-cadherin, thereby disrupting the endothelial barrier function.
Journal ArticleDOI
Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration.
TL;DR: The Platelet concentration required for a positive PRP effect on bone regeneration seems to span a very limited range, and advantageous biological effects seem to occur when PRP with a platelet concentration of approximately 1,000,000/microl is used.
Journal ArticleDOI
A tissue engineering approach to bone repair in large animal models and in clinical practice.
TL;DR: Based on results so far obtained in animal models and pilot clinical studies, one can affirm that the bone tissue engineering approaches, although successful in most cases, need further validation before a wide application in clinics, and the supply of oxygen and nutrients to the cells in the inner part of the implanted scaffolds remains a major concern.
Journal ArticleDOI
Molecular basis of anti‐inflammatory action of platelet‐rich plasma on human chondrocytes: Mechanisms of NF‐κB inhibition via HGF
Paola Bendinelli,Emanuela Matteucci,Giada Dogliotti,Massimiliano M. Corsi,Giuseppe Banfi,Paola Maroni,Maria Alfonsina Desiderio +6 more
TL;DR: In this article, platelet-rich plasma (PRP) was used as a scaffold for articular cartilage regeneration, not only for its content of proliferative/differentiative growth factors, but also for the presence of anti-inflammatory agents including HGF.
Journal ArticleDOI
Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis: A Randomized Controlled Clinical Trial
Christos Thanasas,George Papadimitriou,Charalambos Charalambidis,Ilias Paraskevopoulos,Athanasios Papanikolaou +4 more
TL;DR: PRP treatment seems to be an effective treatment for chronic lateral elbow epicondylitis and superior to autologous blood in the short term and the possibility of cost reduction of the method might justify the use of PRP over autOLOGous whole blood for chronic or refractory tennis elbow.