A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across China based on a nationwide molecular epidemiologic survey.
Xiang He,Hui Xing,Yuhua Ruan,Kunxue Hong,Chun-Lin Cheng,Yuanyuan Hu,Ruolei Xin,Jing Wei,Yi Feng,Jenny H. Hsi,Yutaka Takebe,Yutaka Takebe,Yiming Shao +12 more
TLDR
This study provides the first comprehensive baseline data on the diversity and characteristics of HIV/AIDS epidemic in China, reflecting unique region- and risk group-specific transmission dynamics.Abstract:
Background
China is experiencing a dynamic HIV/AIDS epidemic. While serology based surveillance systems have reported the spread of HIV/AIDS, detailed tracking of its transmission in populations and regions is not possible without mapping it at the molecular level. We therefore conducted a nationwide molecular epidemiology survey across the country.
Methods
HIV-1 genotypes were determined from 1,408 HIV-positive persons newly diagnosed in 2006. The prevalence of each genotype was estimated by weighting the genotype’s prevalence from each province- and risk-specific subpopulation with the number of reported cases in the corresponding subgroups in that year.
Results
CRF07_BC (35.5%), CRF01_AE (27.6%), CRF08_BC (20.1%), and subtype B' (9.6%) were the four main HIV-1 strains in China. CRF07_BC and CRF08_BC were the primary drivers of infection among injecting drug users in northeastern and southeastern China, respectively, and subtype B' remained dominant among former plasma donors in central China. In contrast, all four strains occurred in significant proportions among heterosexuals nationwide, pointing to an expansion of the HIV-1 epidemic from high-risk populations into the general population. CRF01_AE also replaced subtype B as the principal driver of infection among men-who-have-sex-with-men.
Conclusions
Our study provides the first comprehensive baseline data on the diversity and characteristics of HIV/AIDS epidemic in China, reflecting unique region- and risk group-specific transmission dynamics. The results provide information critical for designing effective prevention measures against HIV transmission.read more
Citations
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Visualization and analytics tools for infectious disease epidemiology
Lauren N. Carroll,Alan P. Au,Landon T. Detwiler,Tsung-chieh Fu,Ian Painter,Neil F. Abernethy +5 more
TL;DR: A systematic literature review focused on the landscape of infectious disease visualization tools for public health professionals, with a special emphasis on geographic information systems, molecular epidemiology, and social network analysis, identified several themes: consideration of users' needs, preferences, and computer literacy; integration of tools into routine workflow; complications associated with understanding and use of visualizations; and the role of user trust and organizational support in the adoption of these tools.
Journal ArticleDOI
The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s.
Yi Feng,Xiang He,Jenny H. Hsi,Fan Li,Xingguang Li,Quan Wang,Yuhua Ruan,Hui Xing,Tommy Tsan-Yuk Lam,Oliver G. Pybus,Yutaka Takebe,Yiming Shao +11 more
TL;DR: In this paper, the authors comprehensively analyzed the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China and found that the transmission patterns of these strains are similar to those of the AIDS strain.
Journal ArticleDOI
Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions.
TL;DR: Migration and globalization has contributed to the spread of non-B subtypes contributing to 20–60% of new infections in Europe, Asia and America.
Journal ArticleDOI
Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges.
TL;DR: Great progress has been achieved in the past 20 years in terms of access to and optimization of antiretroviral treatment in China, and the focus of HIV/AIDS treatment has gradually transitioned from urgent care to the management of non-AIDS-related chronic complications and control of chronic inflammation.
Journal ArticleDOI
Geographic origin and evolutionary history of China's two predominant HIV-1 circulating recombinant forms, CRF07_BC and CRF08_BC
Yi Feng,Yutaka Takebe,Yutaka Takebe,Huamian Wei,Xiang He,Xiang He,Jenny H. Hsi,Zhenpeng Li,Hui Xing,Yuhua Ruan,Yao Yang,Fan Li,Jing Wei,Xingguang Li,Yiming Shao +14 more
TL;DR: The results provide compelling evidence for western Yunnan as the geographic origin of CRF07_BC and CRF08_BC, which emerged from a swarm of URFs_BC by a series of recombination events in western Yun Nan in the early 1990s.
References
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