Linda Harris

TL;DR: These data provide the first systematic assessment of the overall neutralization sensitivities of a genetically and geographically diverse panel of circulating HIV-1 strains and can facilitate the systematic characterization of NAb responses elicited by candidate vaccine immunogens.

TL;DR: Assessment of the activities of the subtype B plasmas against chimeric HIV-2 viruses bearing various fragments of the membrane proximal external region of HIV-1 gp41 revealed mixed patterns, implying that MPER neutralization was not dominated by any single specificity akin to known MPER-specific monoclonal Abs.

TL;DR: Using large panels of genetically and geographically diverse HIV-1 Env-pseudotyped viruses and chronic infection plasma samples, it is unambiguously shown that cross-clade nAb responses are commonly induced in response to infection by any virus clade, and neutralization was significantly greater when the plasma clade matched the clade of the virus being tested.

TL;DR: The results reveal the natural diversity of Fc-mediated Ab effector responses among vaccine recipients in the VAX004 trial and in HIV-infected subjects, and they point to the potential importance of polyfunctional Ab responses.

TL;DR: This study defines unique antigen panels to map HIV-1 vaccine-elicited antibody breadth and durability, and experimentally and computationally evaluated humoral responses to define envelope glycoproteins representative of the antigenic diversity of HIV globally.