Journal ArticleDOI
A dual function of copper in designing regenerative implants
Ines Burghardt,Frank Lüthen,Cornelia Prinz,Bernd Kreikemeyer,Carmen Zietz,Hans-Georg Neumann,Joachim Rychly +6 more
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TLDR
T titanium implants that release copper ions can be effective against bacterial infections at higher concentrations of copper near the implant surface and can promote bone regeneration when its concentration becomes lower due to diffusion.About:
This article is published in Biomaterials.The article was published on 2015-03-01. It has received 165 citations till now. The article focuses on the topics: Bone regeneration & Copper.read more
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Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity
TL;DR: It is demonstrated that it is possible to develop multifunctional scaffolds by combining enhanced angiogenesis potential, osteostimulation, and antibacterial properties for the treatment of large bone defects.
Journal ArticleDOI
Antibacterial metals and alloys for potential biomedical implants.
TL;DR: In this article, the development and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail, including antibacterial stainless steel, titanium alloy, zinc and alloy, antibacterial magnesium alloy, and other antibacterial metals and alloys.
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Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis
TL;DR: Results from biofilm based gene expression studies, biofilm growth observation, bacterial viability measurements and morphological examination of bacteria, revealed antimicrobial/antibiofilm activities of Ti-Cu alloy against the oral specific bacterial species, Streptococcus mutans and Porphyromonas gingivalis.
Journal ArticleDOI
Concentration ranges of antibacterial cations for showing the highest antibacterial efficacy but the least cytotoxicity against mammalian cells: implications for a new antibacterial mechanism.
Chengyun Ning,Xiaolan Wang,Lihua Li,Ye Zhu,Mei Li,Peng Yu,Lei Zhou,Zhengnan Zhou,Junqi Chen,Guoxin Tan,Yu Zhang,Yingjun Wang,Chuanbin Mao +12 more
TL;DR: Investigation of their antibacterial mechanism shows that these three metal ions all show antibacterial property through a mechanism of damaging bacterial cell membranes by the generation of reactive oxygen species but surprisingly preserving the integrity of bacterial genomic DNA.
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Recent Advances in Design of Functional Biocompatible Hydrogels for Bone Tissue Engineering
TL;DR: Various design strategies and synthesis methods are introduced to prepare implanted hydrogel scaffolds with tunable mechanical strength, favorable biocompatibility, and excellent bioactivity for applying in bone regeneration.
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Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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Ti based biomaterials, the ultimate choice for orthopaedic implants – A review
TL;DR: In this paper, the influence of alloy chemistry, thermomechanical processing and surface condition on these properties is discussed and various surface modification techniques to achieve superior biocompatibility, higher wear and corrosion resistance.
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Growth Factors, Matrices, and Forces Combine and Control Stem Cells
TL;DR: Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
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Third-generation Biomedical Materials
Larry L. Hench,Julia M. Polak +1 more
TL;DR: The next generation of biomaterials is combining these two properties, with the aim of developing materials that, once implanted, will help the body heal itself.
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Understanding biofilm resistance to antibacterial agents.
TL;DR: The mechanisms that underlie biofilm resistance to antimicrobial chemotherapy will be examined, with particular attention being given to potential avenues for the effective treatment of biofilms.