Showing papers in "Bioactive Materials in 2021"

TL;DR: The changes of TME at various stages during tumor development are required to be further elucidated so that more individualized nanoplatforms could be designed.

TL;DR: This article comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.

TL;DR: In this article, the development and manufacturing of antibacterial metal alloys containing various antibacterial agents were described in detail, including antibacterial stainless steel, titanium alloy, zinc and alloy, antibacterial magnesium alloy, and other antibacterial metals and alloys.

TL;DR: The literature about the different kinds of face masks and respiratory masks, common cases of their application, and the advantages and disadvantages of them in this regard have been reviewed and the related mechanisms of the penetration of the aerosols through the masks are discussed.

TL;DR: The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3% to 25.0% after immersion for 28 days, owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains.

TL;DR: In this paper, a comprehensive review on how metal ions and ion nanoparticles have the potential to decrease or eliminate unwanted bacteria is provided, including specific metal ions such as silver, zinc, copper, iron and gold.

TL;DR: Recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs, and the underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties are discussed.

TL;DR: The principle of cartilage regeneration is discussed, the requirements that have to be fulfilled for the deployment of hydrogels for medical applications are outlined, and the development of advanced hydrogELs with tailored properties for different kinds ofcartilage defects are highlighted to meet the requirements of Cartilage tissue engineering and precision medicine.

TL;DR: In this paper, the authors developed nitrogen-doped fluorescent carbon dots (NCDs) as a multi-mechanism detection for iodide and curcumin in actual complex biological and food samples, which was prepared by a one-step solid phase synthesis using tartaric acid and urea as precursors without adding any other reagents.

TL;DR: Recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

TL;DR: The state of the art of MCSs as tissue-engineered scaffolds for acceleration of bone repair is summarized, including their fabrication methods, critical factors for osteogenesis regulation, current opportunities and challenges in the future.

TL;DR: In this article, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field, and various biomimicking and bio-inspired BTE scaffolds have been reported.

TL;DR: Reduced graphene oxide (RGO) was used as reinforcement in Zn scaffold fabricated via laser additive manufacturing and showed that the homogeneously dispersed RGO simultaneously enhanced the strength and ductility of ZN scaffold.

TL;DR: Wang et al. as discussed by the authors constructed a single-atom sites/N doped porous carbon (Cu SASs/NPC) for photothermal-catalytic antibacterial treatment by a pyrolysis-etching-adsorption-pyrolyysis (PEAP) strategy.

TL;DR: An overview of autogenous/allogenic and ECM-based bone biomaterials for reconstructive surgery and applications of MSCs-mediated bone healing and tissue engineering to further offer principles and effective strategies to optimize M SCs- based bone regeneration are discussed.

TL;DR: In this paper, a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property (308.47 ± 29.20kPa) and excellent hemostatic efficiency (96.5% ± 2.1%) was constructed as a hemostasis sealant.

TL;DR: A straightforward and efficient strategy to construct functional APG scaffold for skin tissue engineering, which has translation potentials in clinical practice is developed.

TL;DR: In vitro and in vivo studies suggested that the combined therapy of PDT, PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death (ICD) and release Damage-associated molecular patterns (DAMPs) which could induce maturation of dendritic cells (DCs) and activate effector cells that robustly evoke the antitumor immune responses for cancer treatment.

TL;DR: In this paper, the authors highlight the recent progress in osteochondral tissue engineering from perspectives of scaffold design, cell encapsulation, and signaling factor incorporation including bioreactor application.

TL;DR: A mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA as mentioned in this paper.

TL;DR: In this article, the authors presented a review of the use of biomimetic hydrogels in bone tissue engineering, and some key factors that can determine the therapy effect for bone tissue regeneration were also mentioned.

TL;DR: In this article, the authors introduced the latest developments of MoS2-nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy.

TL;DR: A multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF (MIL101-NH2) as the core carrier that significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects is constructed.

TL;DR: A CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment, which could be more conducive to clinical application due to its simple preparation and high biological safety.

TL;DR: TiO2 nanorod arrays in combination with irradiation with 808 near-infrared (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and physical killing of bacteria.

TL;DR: In this article, a hyaluronic acid (HA) and chitosan based hydrogel (OHA-CMC) with inherent antibacterial and hemostatic activities fabricated via Schiff base reaction was reported.

TL;DR: This article encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects, as sweeper, mediator and instructor, and systematically classify and discuss the emerging engineering strategies to recruit, activate and modulate the phenotype transition of Macrophages to exploit the power of endogenous macrophage to enhance the performance of engineered bone tissue.

TL;DR: In this article, the authors developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for osteoarthritis (OA) treatment, where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism.

TL;DR: The GNRs/nHA hybrid hydrogel was capable of photothermal treatment of postoperative tumors and bone defect repair in a mice model of tibia osteosarcoma and shows great potential in curing bone tumors and provides a new hope for tumor-related bone complex disease.

TL;DR: Wang et al. as discussed by the authors used modified bioinks comprising gelatin, gelatin methacryloyl (GelMA), and 4-arm poly (ethylene glycol) acrylate (PEG) to fabricate 3D bioprinted scaffolds containing BMSCs, RAW264.7 macrophages, and BMP-4 loaded mesoporous silica nanoparticles (MSNs).