Journal ArticleDOI
A facile synthesis of pyrazole, isoxazole and pyrimidine ortho-dicarboxylic acid derivatives via β-enaminoketoesters
TLDR
In this paper, the total or partial hydrolysis of selected heterocycles afforded the dicarboxylic acids 8, 9 and 10 and the DICARBOXylic acid monoesters 11 and 12.About:
This article is published in Tetrahedron.The article was published on 1997-10-20. It has received 24 citations till now. The article focuses on the topics: Dicarboxylic acid & Isoxazole.read more
Citations
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Journal ArticleDOI
Recent development in preparation reactivity and biological activity of enaminoketones and enaminothiones and their utilization to prepare heterocyclic compounds
TL;DR: Enaminoketones and enaminonitriles have proven to be versatile building blocks for the synthesis of various heterocycles such as pyridine, pyrimidine and pyrrole derivatives.
Journal ArticleDOI
Synthesis of N-Methoxy-N-methyl-β-enaminoketoesters: New Synthetic Precursors for the Regioselective Synthesis of Heterocyclic Compounds
Tobias Persson and,John Nielsen +1 more
TL;DR: This approach provides a diverse entry to densely functionalized heterocyclic compounds, including pyrazoles through regioselective cyclocondensations with hydrazines in a microwave-assisted reaction.
Journal ArticleDOI
A "catch and release" strategy for the parallel synthesis of 2,4,5-trisubstituted pyrimidines.
TL;DR: A resin capture and release strategy for making a combinatorial array of 2,4,5-trisubstituted pyrimidines is demonstrated by capturing beta-ketoesters and Beta-ketoamides on a solid-supported piperazine.
Journal ArticleDOI
Bis(β-Difunctional) Compounds: Versatile Starting Materials for Novel Bis(Heterocycles)
TL;DR: In this paper, the utility of bis(β-difunctional) compounds as intermediates in the synthesis of novel bis(heterocycles) was investigated, and their utility as intermediate for bis-heterocyclic synthesis was shown.
Journal ArticleDOI
A new route to the synthesis of pyrazole and pyrimidine C-nucleoside derivatives
TL;DR: In this paper, a new route to the synthesis of pyrazole and pyrimidine C-nucleosides, which involves as the key step a metal promoted reaction of β-D-ribofuranosyl ketoesters with alkyl cyanoformates is described.
References
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Journal ArticleDOI
Carbon-13 Magnetic Resonance Studies of Azoles. Tautomerism, Shift Reagent Effects, and Solvent Effects
TL;DR: The effects of substitution, lanthanide-shift reagents, solvent changes, and tautomerism were investigated in this article, where it was concluded that chemical shifts are of limited value to ascertain the positions of tautomers.
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Reaction of 2‐dimethylaminomethylene‐1,3‐diones with dinucleophiles. VI. Synthesis of ethyl or methyl 1,5‐disubstituted 1H‐pyrazole‐4‐carboxylates
TL;DR: In this paper, a series of 3-and 5-substituted 1-phenyl-1H-pyrazole-4-carboxylic acids were converted by heating 5-benzyl 1-methyl-1-methyl 1H pyrazole in quantitative yield.
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Tin (IV) Chloride-promoted Synthesis of 4-Aminopyridines and 4-Aminoquinolines
TL;DR: Ortho-aminobenzonitriles as discussed by the authors react with β-ketoesters and alkyl malonates, in the presence of stoichiometric amounts of tin(IV) chloride, to give 4-aminoquinolines 2 and 4amino-2-quinolones 3 respectively.
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Synthesis and characterization of masked aminopyrazolecarboxylic acid synthons
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Metal-catalyzed synthesis of cyano enaminediones from .beta.-dicarbonyl compounds and cyanogen. Identification of Traube's isomers
TL;DR: In this paper, le catalyseur utilise pour la synthese des cyano enaminediones(A) est Zn(acac) 2 ; en presence d'acides ou de bases, les composes A sont transformes en isomeres de Traube: [X 2' acetyl-2' amino-1' vinyl]-2 X-5 methyl-6 pyrimidinecarboxamides-4 (X=acetyl, ethoxycarbonyl, benzoyl) X-4 amino-3