Journal ArticleDOI
A free radical Mannich type reaction: selective α-CH aminomethylation of ethers by Ti(III)/t-BuOOH system under aqueous acidic conditions
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TLDR
In this article, the role of the metal ion in aminomethylation of ethers is discussed and amino-alkylation is also considered and the role role of metal ion is discussed.About:
This article is published in Tetrahedron.The article was published on 2006-06-19. It has received 38 citations till now. The article focuses on the topics: Radical & Iminium.read more
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Direct Sp3α-C-H activation and functionalization of alcohol and ether.
TL;DR: Seven kinds of sp(3)α-C-H activation/C-C formation reactions of alcohols and ethers have been reviewed in this tutorial review, from the viewpoint of both methodology and synthetic application, towards the efficiency, chemo-, regio- and stereoselectivity, catalytic system, substrate scope and mechanistic study.
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Iron-catalyzed C-C bond formation by direct functionalization of C-H bonds adjacent to heteroatoms.
Zhiping Li,Rong Yu,Haijun Li +2 more
TL;DR: Transition-metal-catalyzed C H functionalization for the atomand step-economical synthesis of functional molecules has attracted tremendous efforts in both academia and industry, with high efficiency, low cost, and minimal environmental impact.
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Radical addition to iminium ions and cationic heterocycles.
TL;DR: This review covers diverse reactions of preformed or in situ-generated cationic substrates with various types of C-radicals, including alkyl, alkoxyalkyl, trifluoromethyl, aryl, acyl, carbamoyl, and alkoxycarbonyl species.
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Intermolecular radical carboaminohydroxylation of olefins with aryl diazonium salts and TEMPO.
TL;DR: Highly reactive aryl radicals can selectively be reacted with a broad variety of activated and nonactivated olefinic substrates in the presence of nitroxyl radicals.
References
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Book
Handbook of Bond Dissociation Energies in Organic Compounds
TL;DR: A Database of BDEs can be found in this article, where the authors discuss the need for reliable BDE data and how to use the tables of the BDE Data.
Journal ArticleDOI
Modern Variants of the Mannich Reaction
TL;DR: Modern variants of the Mannich reaction that expand the potential of the classical intermolecular reaction significantly and enable efficient control of the regioselectivities and stereoselectivity are therefore the topic of intensive research.
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The direct catalytic asymmetric mannich reaction.
TL;DR: The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-aminos alcohols.
Journal ArticleDOI
Further advances in the chemistry of mannich bases
M. Tramontini,Luigi Angiolini +1 more