Journal ArticleDOI
A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.
TLDR
Findings support the hypothesis that the functional polymorphism in the COMT gene may modify the phenotype of suicide attempts and anger-related traits.About:
This article is published in Biological Psychiatry.The article was published on 2003-07-01. It has received 184 citations till now. The article focuses on the topics: Catechol-O-methyl transferase & Genotype frequency.read more
Citations
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Journal ArticleDOI
The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes.
TL;DR: It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.
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Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review.
TL;DR: Concept background and empirical evidence investigating roles of traits in suicidal behaviors investigating involvement of personality traits in susceptibility to suicidality are reviewed.
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The neurobiology of psychopathic traits in youths
TL;DR: Children with conduct disorder have psychopathic traits, which consist of a callous–unemotional component and an impulsive–antisocial component, which are associated with two core impairments.
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The Psychology and Neurobiology of Suicidal Behavior
TL;DR: It is concluded that from both neurobiological and psychological perspectives, extant research findings converge on the view that two general categories of risk for suicide can be identified: dysregulated impulse control and propensity to intense psychological pain.
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Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder
Michael Berk,Michael Berk,Seetal Dodd,Márcia Kauer-Sant'Anna,Gin S Malhi,Michel Bourin,Flávio Kapczinski,Trevor R. Norman +7 more
TL;DR: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model, but there is a wealth of converging data on the role of dopamine, and the possibility of a dopamine hypothesis for bipolar disorder is examined.
References
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Journal ArticleDOI
Toward a clinical model of suicidal behavior in psychiatric patients.
TL;DR: A stress-diathesis model is proposed in which the risk for suicidal acts is determined not merely by a psychiatric illness but also by a diathesis, reflected in tendencies to experience more suicidal ideation and to be more impulsive and, therefore, more likely to act on suicidal feelings.
Journal Article
Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.
Pekka T. Männistö,Seppo Kaakkola +1 more
TL;DR: The enzyme responsible for the O- methylation, catechol- O -methyltransferase (COMT) was partly purified and characterized by the same group as EC, which first described the enzyme-catalyzed O-methylation of catechlamines and other catechols in the late 1950s.
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Sexual identity of gout patients
TL;DR: In this article, the psychodynamic effects of oestrogen psychodynamic facts in the sense of latent homoerotic characteristics are discussed for the explaination of the fact that most often men are affected from gout.
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Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
Joseph A. Gogos,Maria A. Morgan,Victoria N. Luine,Miklós Sántha,Sonoko Ogawa,Donald W. Pfaff,Maria Karayiorgou +6 more
TL;DR: The results provide conclusive evidence for an important sex- and region-specific contribution of COMT in the maintenance of steady-state levels of catecholamines in the brain and suggest a role for comT in some aspects of emotional and social behavior in mice.
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SUICIDAL BEHAVIOR RUNS IN FAMILIES A Controlled Family Study of Adolescent Suicide Victims
TL;DR: Lability to suicidal behavior might be familially transmitted as a trait independent of Axis I and II disorders.