A Methodology For Performing Global Uncertainty And Sensitivity Analysis In Systems Biology
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TLDR
This work develops methods for applying existing analytical tools to perform analyses on a variety of mathematical and computer models and provides a complete methodology for performing these analyses, in both deterministic and stochastic settings, and proposes novel techniques to handle problems encountered during these types of analyses.About:
This article is published in Journal of Theoretical Biology.The article was published on 2008-09-07 and is currently open access. It has received 2014 citations till now. The article focuses on the topics: Uncertainty analysis & Sensitivity analysis.read more
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A predator–prey model with Crowley–Martin functional response: A nonautonomous study
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Intermittent Preventive Treatment (IPT) and the Spread of Drug Resistant Malaria
Miranda I. Teboh-Ewungkem,Olivia Prosper,Katharine Gurski,Carrie A. Manore,Angela Peace,Zhilan Feng +5 more
TL;DR: The model results suggest that the schedule of IPT may have an important influence on the prevalence of resistant infections as well as the total infections of both strains.
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Modelling gross primary production in the Heihe river basin and uncertainty analysis
TL;DR: In this article, an 8-day composite gross primary production (GPP) is estimated using the region production efficiency model REG-PEM in the Heihe river basin from 2006 to 2008.
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Analysis of an age-structured tuberculosis model with treatment and relapse
TL;DR: In this paper, a new tuberculosis model consisting of ordinary differential equations and partial differential equations is established, and the basic reproduction number is identified for this model, and show that the $$\mathcal {R}_{0}$$ determines the global dynamics of the model.
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A Tumor-Immune Interaction Model for Synergistic Combinations of Anti PD-L1 and Ionizing Irradiation Treatment.
TL;DR: The approach using the model showed that an increase in the expression level of PD-1 and PD-L1 was proportional to tumor growth before therapy, but not after initiating therapy, highlighting that the ratio of PD/L1 in T cells could be considered in combination therapy.
References
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Book
An Introduction to Multivariate Statistical Analysis
TL;DR: In this article, the distribution of the Mean Vector and the Covariance Matrix and the Generalized T2-Statistic is analyzed. But the distribution is not shown to be independent of sets of Variates.
Journal ArticleDOI
A comparison of three methods for selecting values of input variables in the analysis of output from a computer code
TL;DR: In this paper, two sampling plans are examined as alternatives to simple random sampling in Monte Carlo studies and they are shown to be improvements over simple sampling with respect to variance for a class of estimators which includes the sample mean and the empirical distribution function.
Journal Article
Factorial sampling plans for preliminary computational experiments
TL;DR: The proposed experimental plans are composed of individually randomized one-factor-at-a-time designs, and data analysis is based on the resulting random sample of observed elementary effects, those changes in an output due solely to changes in a particular input.
Journal ArticleDOI
Factorial sampling plans for preliminary computational experiments
TL;DR: In this article, the problem of designing computational experiments to determine which inputs have important effects on an output is considered, and experimental plans are composed of individually randomized one-factor-at-a-time designs, and data analysis is based on the resulting random sample of observed elementary effects.