Journal ArticleDOI
A multivariate analysis of risk factors for preeclampsia.
Reads0
Chats0
TLDR
There are a number of risk factors for preeclampsia that may be determined early in a woman's pregnancy that share certain risk factors but not others, and a cohort investigation is needed to determine the ability of these risk factors to predict who develops preeClampsia.Abstract:
Objective. —To determine, in a multivariate analysis, risk factors for preeclampsia that could be observed early in pregnancy and to establish whether these risk factors are different for nulliparas and multiparas. Design. —A case-control study of preeclampsia. Setting. —Women who gave birth at Northern California Kaiser Permanente Medical Centers in 1984 and 1985. Participants. —Preeclamptic cases (n =139) were determined from discharge diagnosis of severe preeclampsia and by confirmation of blood pressures and proteinuria from medical records. Controls (n = 132) were randomly selected women who had no discharge diagnosis of any hypertensive disorder of pregnancy and who had no evidence of hypertension or proteinuria from medical record review. Main Variables Examined. —Medical records were abstracted for information regarding maternal age, race, previous pregnancy history, family medical history, socioeconomic status, employment during pregnancy, body mass, and smoking and alcohol consumption. Results. —Multiple logistic regression analyses confirmed that case patients were more likely than control patients to be nulliparous (adjusted odds ratio [OR], 5.4; 95% confidence interval [CI], 2.8 to 10.3) and that preeclampsia in a previous pregnancy greatly increased the risk in a subsequent one (adjusted OR, 10.8; 95% CI, 1.2 to 29.1). However, regardless of parity, preeclamptic women were also more likely to be of high body mass (adjusted OR, 2.7; 95% CI, 1.2 to 6.2), to work during pregnancy (adjusted OR, 2.1; 95% CI, 1.1 to 4.4), and to have a family history of hypertension (adjusted OR, 1.7; 95% CI, 0.92 to 3.2). Having a previous history of a spontaneous abortion was protective but only in multiparous women (adjusted OR for multiparas, 0.09; 95% CI, 0.02 to 0.48). In contrast, being black was a significant risk for preeclampsia but only in nulliparous women (adjusted OR for nulliparas, 12.3; 95% CI, 1.6 to 100.8). Conclusions. —There are a number of risk factors for preeclampsia that may be determined early in a woman's pregnancy. Multiparas and nulliparas share certain risk factors but not others. A cohort investigation is needed to determine the ability of these risk factors to predict who develops preeclampsia. (JAMA. 1991;266:237-241)read more
Citations
More filters
Journal ArticleDOI
Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
TL;DR: Factors that may be present at antenatal booking and the underlying evidence base can be used to assess risk at booking so that a suitable surveillance routine to detect pre-eclampsia can be planned for the rest of the pregnancy.
Journal ArticleDOI
Prepregnancy Weight and the Risk of Adverse Pregnancy Outcomes
TL;DR: Higher maternal weight before pregnancy increases the risk of late fetal death, although it protects against the delivery of a small-for-gestational-age infant.
Journal ArticleDOI
Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success
Susan E. Hiby,James J. Walker,Kevin M. O'Shaughnessy,Christopher W.G. Redman,Mary Carrington,John Trowsdale,Ashley Moffett +6 more
TL;DR: In this article, the authors tested the idea that recognition of these molecules by killer immunoglobulin receptors (KIRs) on maternal decidual NK cells is a key factor in the development of preeclampsia.
Journal ArticleDOI
Pre-eclampsia part 1: current understanding of its pathophysiology
TL;DR: The diagnosis, classification, clinical manifestations and putative pathogenetic mechanisms of pre-eclampsia are discussed.
Journal ArticleDOI
Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia
Lisa M. Bodnar,Janet M. Catov,Hyagriv N. Simhan,Michael F. Holick,Robert W. Powers,James M. Roberts +5 more
TL;DR: A nested case-control study of pregnant women followed from less than 16 wk gestation to delivery to assess the effect of maternal 25-hydroxyvitamin D [25(OH)D] concentration on the risk of preeclampsia and the vitamin D status of newborns of preeClamptic mothers.
References
More filters
Journal ArticleDOI
Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae.
TL;DR: Low-dose aspirin may restore prostacyclin/thromboxane imbalance, previously suggested as an important aetiological factor in PIH and pre-eclampsia, and be reinstated in mothers or infants.
Journal ArticleDOI
Prevention of pre-eclampsia by early antiplatelet therapy
TL;DR: Antiplatelet therapy given early in pregnancy to high-risk patients may protect against pre-eclampsia and fetal growth retardation.
Journal ArticleDOI
Severe preeclampsia-eclampsia in young primigravid women: Subsequent pregnancy outcome and remote prognosis
TL;DR: Within thenormotensive group, patients remaining normotensive in subsequent pregnancies had the lowest incidence of chronic hypertension, and patients having preeclampsia-eclamptic in their second pregnancies had a significantly higher incidence of subsequent chronic hypertension.
Journal ArticleDOI
The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies
Eyal Schiff,E Peleg,Mordechai Goldenberg,T Rosenthal,E Ruppin,M Tamarkin,G. Barkai,Gilad Ben-Baruch,I Yahal,J Blankstein +9 more
TL;DR: It is concluded that low daily doses of aspirin taken during the third trimester of pregnancy significantly reduce the incidence of pregnancy-induced hypertension and pre-eclamptic toxemia in women at high risk for these disorders, possibly through the correction of an imbalance between levels of thromboxane and prostacyclin.
Journal ArticleDOI
Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension.
Ariela Benigni,Gina Gregorini,Tiziana Frusca,Chiara Chiabrando,Stefania Ballerini,Adriana Valcamonico,Silvia Orisio,Antonella Piccinelli,Vittorio Pinciroli,Roberto Fanelli,Attilio Gastaldi,Giuseppe Remuzzi +11 more
TL;DR: In this article, the effect of low-dose aspirin on platelet thromboxane A2 and vascular prostacyclin in women at risk for pregnancy-induced hypertension was investigated.