Journal ArticleDOI
A New Approach for the Synthesis of α-Methylene-γ-Butyrolactones from α-Bromomethyl Acrylic Acids (or Esters)
TLDR
In this article, a new approach for the synthesis of α-methylene-γ-butyrolactones from the reaction of αbromomethyl acrylic acid (or ester), powdered tin and carbonyl compounds in one pot with excellent to good yields is presented.About:
This article is published in Synthetic Communications.The article was published on 1992-02-01. It has received 37 citations till now. The article focuses on the topics: Acrylic acid & Methylene.read more
Citations
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Journal ArticleDOI
Organic syntheses using indium-mediated and catalyzed reactions in aqueous media
Chao-Jun Li,Tak Hang Chan +1 more
TL;DR: Indium-Mediated Barbier-type reactions as discussed by the authors have been used for a variety of purposes, such as the synthesis of sialic acids and carbohydrate homologations.
Journal ArticleDOI
Aqueous Barbier-Grignard type reaction: Scope, mechanism, and synthetic applications
Journal ArticleDOI
A simple and clean procedure for three-component synthesis of spirooxindoles in aqueous medium
TL;DR: In this paper, a simple and efficient one-pot three-component synthesis of the biologically important spirooxindoles scaffold was carried out by the reaction of isatin, activated methylene reagent, and 1,3-dicarbonyl compounds in aqueous medium.
Journal ArticleDOI
Perspectives on green synthesis and catalysis
Yiram Kim,Chao-Jun Li +1 more
TL;DR: In this article, the authors illustrate three distinct green approaches, studying the novel reactivities with environmentally innocuous reagents to improve the synthetic efficiency, utilization of natural feedstocks, and employment of green energy to facilitate various important chemical transformations.
Journal ArticleDOI
Copper Ferrite Nanoparticles: An Efficient and Reusable Nanocatalyst for a Green One-Pot, Three-component Synthesis of Spirooxindoles in Water
TL;DR: A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported.
References
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Journal ArticleDOI
Synthesis and Biological Activity of α‐Methylene‐γ‐butyrolactones
H. M. R. Hoffmann,Jürgen P. Rabe +1 more
TL;DR: In this paper, the synthesis of the heterocycle and classification of the synthetic methods are not only of practical interest, but also fundamentally important as a current example for the construction of an unusual 1,4-functionality distance and an α-substituted acrylic ester moiety which is susceptible to nucleophilic attack.
Journal ArticleDOI
Synthesis of α-Methylene-γ-Butyrolactones
TL;DR: The development of natural product synthesis is synonomous with the chemistry of unsaturated carbonyl compounds as mentioned in this paper, which is often used for reductive alkylation, extended enolate alkylations and many other important synthetic operations.
Journal ArticleDOI
Carboxylation of .gamma.-butyrolactones with methyl methoxymagnesium carbonate. New synthesis of DL-protolichesterinic acid
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A FACILE AND STEREOSELECTIVE SYNTHESIS OF α-METHYLENE-γ-BUTYROLACTONE BY MEANS OF CHROMIUM(II) REAGENT
TL;DR: In this paper, the treatment of ethyl α-(bromomethyl)acrylate with Cr(II) reagent derived from CrCl3 and LiAlH4 produces allylic chromium species which add to aldehydes efficiently to give α-methylene-γ-butyrolactones stereoselectively.
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