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Journal ArticleDOI

A New Fluid-Chip Co-Design for Digital Microfluidic Biochips Considering Cost Drivers and Design Convergence

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TLDR
This paper aims to propose a fluid-chip co-design methodology in dealing with the consideration of the fluid- chip cost drivers, while reducing the design cycles in between.
Abstract
The design process for digital microfluidic biochips (DMFBs) is becoming more complex due to the growing need for essential bio-protocols. A number of significant fluid- and chip-level synthesis tools have been offered previously for designing an efficient system. Several important cost drivers like bioassay schedule length, total pin count, congestion-free wiring, total wire length, and total layer count together measure the efficiency of the DMFBs. Besides, existing design gaps among the sub-tasks of the fluid and chip level make the design process expensive delaying the time-to-market and increasing the overall cost. In this context, removal of design cycles among the sub-tasks is a prior need to obtain a low-cost and efficient platform. Hence, this paper aims to propose a fluid-chip co-design methodology in dealing with the consideration of the fluid-chip cost drivers, while reducing the design cycles in between. A simulation study considering a number of benchmarks has been presented to observe the performance.

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Proceedings ArticleDOI

A Design Optimization for Pin-Constrained Paper-based Digital Microfluidic Biochips Integrating Fluid-Control Co-Design Issues

TL;DR: This paper presents a fluid-control co-design considering several important cost-driving issues like minimization of schedule length, control pin count, and wirelength, together with congestion-free and conflict-free wiring.
Journal ArticleDOI

An Integrated Co-Design of Flow-Based Biochips Considering Flow-Control Design Issues and Objectives

TL;DR: With increasing effectiveness of flow-based microfluidic biochips in the field of biochemical experiments and point-of-care diagnosis, design automation demands enormous attention to integrate the technology into the design process.
Journal ArticleDOI

A Predictive Model for Fluid-Control Codesign of Paper-Based Digital Biochips Following a Machine Learning Approach

TL;DR: A machine learning-based model is built to predict violation in control design beforehand and accordingly guides the fluid-control codesign to tackle important cost-driving issues while attaining congestion- and conflict-free wiring and effectively eliminates the design cycles producing a low-cost platform.
Journal ArticleDOI

Attack-Detection and -Recovery: An Integrated Approach Towards Attack-Tolerant Cyber-Physical Digital Microfluidic Biochips

TL;DR: In this article , an attack-tolerant synthesis is proposed with two-way security through integrating attack-detection and attack-recovery from various Denial of Service attacks.
References
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Proceedings ArticleDOI

Droplet Routing in the Synthesis of Digital Microfluidic Biochips

TL;DR: This work develops the first systematic droplet routing method that can be integrated with biochip synthesis, which minimizes the number of cells used fordroplet routing, while satisfying constraints imposed by throughput considerations and fluidic properties.
Book ChapterDOI

Approximating Maximum Independent Sets by Excluding Subgraphs

TL;DR: An approximation algorithm for the maximum independent set problem is given, improving the best performance guarantee known to n/(log n)2, and this can be combined into a surprisingly strong simultaneous performance guarantee for the clique and coloring problems.
Journal ArticleDOI

High-level synthesis of digital microfluidic biochips

TL;DR: This work proposes a system design methodology that attempts to apply classical high-level synthesis techniques to the design of digital microfluidic biochips and develops an optimal scheduling strategy based on integer linear programming and two heuristic techniques that scale well for large problem instances.
Proceedings ArticleDOI

Unified high-level synthesis and module placement for defect-tolerant microfluidic biochips

TL;DR: This work presents a synthesis methodology that unifies operation scheduling, resource binding, and module placement for such "digital" biochips and can also be used after fabrication to bypass defective cells in the microfluidic array.
Proceedings ArticleDOI

Architectural-level synthesis of digital microfluidics-based biochips

TL;DR: A system design methodology is proposed that attempts to apply classical architectural-level synthesis techniques to the design of digital microfluidics-based biochips and develops an optimal scheduling strategy based on integer linear programming and two heuristic techniques that scale well for large problem instances.
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