Journal ArticleDOI
A new method for the preparation of tertiary butyl ethers and esters
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TLDR
T-butyl 2,2,2-trichloroacetimidate is an efficient reagent for the preparation of t- butyl ethers and esters in the presence of a catalytic amount of boron trifluoride etherate.About:
This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 152 citations till now. The article focuses on the topics: Trichloroacetonitrile & Boron trifluoride.read more
Citations
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A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling
TL;DR: New DOTA-based bifunctional prochelators for a broad application in the modification of biomolecules with metal ions were prepared and the coupling of 6d to a bioactive peptide on solid-phase was exemplified with use of a CCK-B (cholecystokinin) analogue.
Journal ArticleDOI
Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities
Tsutomu Agatsuma,Harumi Ogawa,Kazuhito Akasaka,Akira Asai,Yoshinori Yamashita,Tamio Mizukami,Shiro Akinaga,Yutaka Saitoh +7 more
TL;DR: Novel halohydrin and oxime derivatives of radicicol showed significantly improved antitumor activities than those of 1 in vitro as tested in a cell proliferation assay and in vivo using sc-inoculated human breast carcinoma and epidermoid tumor models.
Journal ArticleDOI
The preparation of optically active 2-cyclopenten-1,4-diol derivatives from furfuryl alcohol
TL;DR: Preparation and enzymatic resolution of several cis-mono-4-O-protected-2-cyclopenten-1,4-diols and stereoselective acylation was conducted to afford the corresponding alcohols and acetates in moderate to excellent enantioselectivities.
Journal ArticleDOI
Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains.
Damien Boeglin,William D. Lubell +1 more
TL;DR: A general Fmoc-protection protocol for the stepwise solid-phase synthesis of aza-peptides has now been developed based on the activation of N'-alkyl fluoren-9-ylmethyl carbazates with phosgene for coupling the aze-amino acid residues.
References
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New Methods for the Synthesis of Glycosides and Oligosaccharides—Are There Alternatives to the Koenigs‐Knorr Method? [New Synthetic Methods (56)]
TL;DR: Emphasis is placed on glycoside and saccharide formation by 1-O-alkylation, on the trichloroacetimidate method, and on activation through the formation of glycosylsulfonium salts and Glycosyl fluorides.
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Imidoester, I. Darstellung von Trichloracetimidsäureestern
TL;DR: In this article, trichloracetonitril lagert leicht Alkohole unter Bildung von Trichloracetimidsaureestern an: die Reaktion wird durch Alkali (Alkoholat, Salze der Alkoxysauren, Carbonat) katalysiert.
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Darstellung von Carbonsäureestern mittels O‐Alkyl‐N.N′‐dicyclohexyl‐isoharnstoffen
TL;DR: O-Alkyl-N.N′-dicyclohexyl-isoharnstoffe reagieren mit carbonsauren zu Carbonsaureestern.
Journal ArticleDOI
Imidoester, V. Die Umlagerung von Trichloracetimidaten zu N‐substituierten Säureamiden
TL;DR: In this paper, the durch Bortrifluorid katalysierte Umlagerung von Alkyl-trichloracetimidaten (I, R = CCl3, R′ = Alkyls, R″ = H) zu N-substituierten Saureamiden verlauft uber einen ionischen Mechanismus.
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Convenient one-pot esterification of N-protected aminoacids via isopropenyl chloroformate activation.
TL;DR: In this paper, N-protected aminoacids by isopropenyl chloroformate leads to esters of primary, secondary and tertiary alcohols with 4-dimethylamino-pyridine as catalyst.
Related Papers (5)
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Benzyl trichloroacetimidate, a versatile reagent for acid-catalysed benzylation of hydroxy-groups
Tommy Iversen,David R. Bundle +1 more