Journal ArticleDOI
A new method for the preparation of tertiary butyl ethers and esters
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TLDR
T-butyl 2,2,2-trichloroacetimidate is an efficient reagent for the preparation of t- butyl ethers and esters in the presence of a catalytic amount of boron trifluoride etherate.About:
This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 152 citations till now. The article focuses on the topics: Trichloroacetonitrile & Boron trifluoride.read more
Citations
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A General Strategy for the Synthesis of Large Peptides: r1~he Combined Solid-Phase and Solution Approach.
TL;DR: The Naα-Fmoc(9-fluorenylmethoxycarbonyl) method allows the selective acidolytic cleavage of fully protected peptides with a free α-carboxyl group from the solid-phase resin to give products in high yield and purity.
Journal ArticleDOI
Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen
Robert M. Adlington,Jack E. Baldwin,Gerald W. Becker,Beining Chen,Leifeng Cheng,Stephen L. Cooper,Hermann Robert Bell,Trevor J. Howe,William McCoull,Ann M. McNulty,Blake Lee Neubauer,Gareth J. Pritchard +11 more
TL;DR: It is concluded that the design approach has been successful in developing PSA inhibitors and could also be applied to the inhibition of other enzymes, especially in the absence of crystallographic information.
Journal ArticleDOI
Total synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) and 2-deoxy-beta-KDO.
TL;DR: In this article, total synthesisation of KDO and 2-deoxy-β-KDO is reported, and the C2-symmetric dienediol was desymmetrized by conversion to its corresponding 1,4-dioxanone.
Journal ArticleDOI
Stereospecific synthesis of dealanylalahopcin
TL;DR: In this article, the first α-amino acid dealanylalahopcin starting from (L) -aspartic acid was described, and the first synthesis of the novel α-AMINO acid was performed starting from
Journal ArticleDOI
9‐Fluorenylmethyloxycarbonyl/ tbutyl‐based convergent protein synthesis
Kleomenis Barlos,Dimitrios Gatos +1 more
TL;DR: This review summarizes CPS performed utilizing the mild 9-fluorenylmethyloxycarbonyl/tbutyloxy carbonyl-based protecting scheme for the amino acids.
References
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Journal ArticleDOI
New Methods for the Synthesis of Glycosides and Oligosaccharides—Are There Alternatives to the Koenigs‐Knorr Method? [New Synthetic Methods (56)]
TL;DR: Emphasis is placed on glycoside and saccharide formation by 1-O-alkylation, on the trichloroacetimidate method, and on activation through the formation of glycosylsulfonium salts and Glycosyl fluorides.
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Imidoester, I. Darstellung von Trichloracetimidsäureestern
TL;DR: In this article, trichloracetonitril lagert leicht Alkohole unter Bildung von Trichloracetimidsaureestern an: die Reaktion wird durch Alkali (Alkoholat, Salze der Alkoxysauren, Carbonat) katalysiert.
Journal ArticleDOI
Darstellung von Carbonsäureestern mittels O‐Alkyl‐N.N′‐dicyclohexyl‐isoharnstoffen
TL;DR: O-Alkyl-N.N′-dicyclohexyl-isoharnstoffe reagieren mit carbonsauren zu Carbonsaureestern.
Journal ArticleDOI
Imidoester, V. Die Umlagerung von Trichloracetimidaten zu N‐substituierten Säureamiden
TL;DR: In this paper, the durch Bortrifluorid katalysierte Umlagerung von Alkyl-trichloracetimidaten (I, R = CCl3, R′ = Alkyls, R″ = H) zu N-substituierten Saureamiden verlauft uber einen ionischen Mechanismus.
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Convenient one-pot esterification of N-protected aminoacids via isopropenyl chloroformate activation.
TL;DR: In this paper, N-protected aminoacids by isopropenyl chloroformate leads to esters of primary, secondary and tertiary alcohols with 4-dimethylamino-pyridine as catalyst.
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Benzyl trichloroacetimidate, a versatile reagent for acid-catalysed benzylation of hydroxy-groups
Tommy Iversen,David R. Bundle +1 more