Journal ArticleDOI
A novel regional citrate anticoagulation protocol for CRRT using only commercially available solutions
Sheldon Tobe,Prince Aujla,Aziz A. Walele,Matthew J. Oliver,David Naimark,Nancy Perkins,Marianne Beardsall +6 more
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TLDR
It is possible to provide safe and effective CRA with only commercially available solutions for units that do not want or cannot prepare extemporaneously made solutions.About:
This article is published in Journal of Critical Care.The article was published on 2003-06-01. It has received 71 citations till now.read more
Citations
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Journal ArticleDOI
Clinical review: Patency of the circuit in continuous renal replacement therapy
TL;DR: Non-anticoagulant and anticoaggulant measures to prevent circuit failure and regional anticoagulation with citrate emerges as the most promising method.
Journal ArticleDOI
Multi-centre evaluation of anticoagulation in patients receiving continuous renal replacement therapy (CRRT)
Patrick D. Brophy,Michael J. Somers,Michelle A. Baum,Jordan M. Symons,Nancy McAfee,James D. Fortenberry,Kristine Rogers,Joni Barnett,Douglas L. Blowey,Cheryl Baker,Timothy E. Bunchman,Stuart L. Goldstein +11 more
TL;DR: While the standard hepACG and citACG methods studied in the prospective paediatric CRRT registry led to similar filter life spans and were superior to noACG, the data suggest that cit ACG may result in less life-threatening complications.
Journal ArticleDOI
Sustained low-efficiency dialysis in the ICU: Cost, anticoagulation, and solute removal
TL;DR: Sustained low-efficiency daily dialysis may be routinely performed without anticoagulation; it provides solute removal equivalent to CRRT at significantly lower cost.
Journal ArticleDOI
Anticoagulation strategies in continuous renal replacement therapy: can the choice be evidence based?
TL;DR: The implementation of regional anticoagulation with citrate is worthwhile to reduce bleeding risk and future trials should be randomized and have sufficient power and well defined endpoints to compensate for the complexity of critical illness-related pro- and antICOagulant forces.
Journal ArticleDOI
Bench-to-bedside review: Citrate for continuous renal replacement therapy, from science to practice
TL;DR: Evidence has accumulated that regional anticoagulation of the CRRT circuit with citrate is feasible and safe, and citrate should become the first choice antICOagulant for CRRT provided that its safe use can be guaranteed.
References
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Journal ArticleDOI
Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients
TL;DR: In 2,000 hours of citrate CAVHD in eleven critically patients, this system has proved smooth, practical and effective, and has minimized the risks of hemorrhage and thrombocytopenia encountered with heparin use.
Journal ArticleDOI
Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding
Runolfur Palsson,John L. Niles +1 more
TL;DR: Two patients, one with septic shock and the other with fulminant hepatic failure, developed evidence for citrate toxicity without a significant alteration in clinical status, and this simplified technique of regional anticoagulation with citrate is an effective and safe form of antICOagulation for CVVH in critically ill patients with a high risk of bleeding.
Journal ArticleDOI
Effect of anticoagulation on blood membrane interactions during hemodialysis
Roland Hofbauer,Doris Moser,Michael Frass,Rainer Oberbauer,Alan D. Kaye,O. Wagner,Stylianos Kapiotis,Wilfred Druml +7 more
TL;DR: The results of this investigation indicate that using sodium citrate as an anticoagulant during hemodialysis induces a lower activation of coagulation than both conventional and fractionated heparin, which might contribute to an improvement of biocompatibility of he modialysis extracorporeal circulation.
Journal ArticleDOI
Regional citrate anticoagulation in continuous venovenous hemodiafiltration
TL;DR: Guiding regional citrate anticoagulation through the use of posthemofilter ionized calcium levels is a safe and effective method of prolonging filter life during CVVHDF.
Journal ArticleDOI
Effects of bicarbonate- and lactate-buffered replacement fluids on cardiovascular outcome in CVVH patients.
TL;DR: The data suggest that the use of RF-bic during CVVH reduces cardiovascular events in critically ill patients with acute renal failure, particularly those with previous cardiovascular disease or heart failure, and that the administration of RF -bic solution was superior in normalizing acidosis of patients without the risk of alkalosis.
Related Papers (5)
Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding
Runolfur Palsson,John L. Niles +1 more