Journal ArticleDOI
A possible role of prostaglandins in the inhibition of natural and antibody-dependent cell-mediated cytotoxicity against tumor cells.
Michael J. Droller,Michael J. Droller,Michael Schneider,Michael Schneider,Peter Perlmann,Peter Perlmann +5 more
TLDR
It appears that the production of prostaglandins by tumor cells may constitute a means by which the tumor cells subvert the effect of a cellular immune response that is directed against them.About:
This article is published in Cellular Immunology.The article was published on 1978-08-01. It has received 223 citations till now. The article focuses on the topics: Prostaglandin E & Lymphocyte.read more
Citations
More filters
Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Journal ArticleDOI
Regulation of the immune response by prostaglandins.
TL;DR: A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo and results in an enhanced cellular immune response in a number of different experimental systems.
Journal ArticleDOI
Regulation of the immune response by prostaglandins
James S. Goodwin,Jan Ceuppens +1 more
TL;DR: Of all the arachidonic acid metabolites, only prostaglandin E (PGE) has been shown to have a clear role in the regulation of cellular and humoral immune responses.
Book ChapterDOI
The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.
TL;DR: The developments in macrophage biology over the past few years were not predicted till 1972, and Macrophages are definitely involved in some response to many of the conventional polyclonal stimuli.
Journal ArticleDOI
Aspirin use, cancer, and polyps of the large bowel
TL;DR: The effect of aspirin use on 490 patients with cancer of the colon, 340 withcancer of the rectum as the first primary site, and 212 patients with polyps having no coexisting malignancies was compared with that of two groups of control subjects that consisted of 524 hospital patients having no cancers and no diseases of the digestive organs.
References
More filters
Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TL;DR: Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.
Book ChapterDOI
Cytotoxic effects of lymphoid cells in vitro.
Peter Perlmann,Göran Holm +1 more
TL;DR: The study of the various pathways by which lymphoid cells can become cytotoxic has been helpful for the understanding of effector role of these cells in cell-destructive reactions in general.
Journal ArticleDOI
Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen.
TL;DR: The permanent presence of tumour‐specific antigen (TSA) in this carcinoma cell line suggests that the TSA is a genetically determined characteristic of T24 cells.
Book ChapterDOI
Cellular immunity against tumor antigens.
TL;DR: The demonstration of cellular immunity to TSTA implies that autochthonous neoplasms appear in the presence of immune lymph node cells, which can destroy their cells at least in vitro .
Journal Article
The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes.
TL;DR: Results suggest that cAMP occupies a central modulatory role in the expression of cytolytic activity by lymphocytes and prevents the effect of the prostaglandins or histamine in either system.