Book ChapterDOI
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
TLDR
Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells, which is most often highly specific and requires intimate contact rather than release of diffusible toxic factors.Abstract:
Publisher Summary The term “cell-mediated cytotoxicity” applies to lytic reactions that require the participation of lymphoid or non-lymphoid cells but not of added complement. It has been clearly established that several pathways, including different cell types, are involved in cytotoxic reactions in vitro. With membrane-associated antigens, such as transplantation, and tumor-associated antigens, the cytotoxic effect of effector cells on adequate target cells is most often highly specific and requires intimate contact rather than release of diffusible toxic factors. Specific cell-mediated cytotoxicity in vitro can be divided into three categories according to the nature of the effector cells.read more
Citations
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Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Book ChapterDOI
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
TL;DR: This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
Journal ArticleDOI
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
David Kägi,Birgit Ledermann,Kurt Bürki,Peter Seiler,Bernhard Odermatt,Kristin J. Olsen,Eckhard R. Podack,Rolf M. Zinkernagel,Hans Hengartner +8 more
TL;DR: Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore formation involving perform, and perforin is therefore a key effector molecule for T-cell- and natural Killer- cell-mediated cy tolysis.
Journal ArticleDOI
Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity
David Kägi,Françoise Vignaux,Birgit Ledermann,Kurt Bürki,Valérie Depraetere,Shigekazu Nagata,Hans Hengartner,Pierre Golstein +7 more
TL;DR: The perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays, and no third mechanism was detected.
Journal ArticleDOI
Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.
TL;DR: The ability of the hybridoma IgG to inhibit mouse FcRII was independent of the major histocompatibility complex and the monoclonal 2.4G2 IgG antigenic determinant was not present on rat, guinea pig, rabbit, or human F cR-bearing cells.
References
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Journal ArticleDOI
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.
TL;DR: It is indirectly shown that all or at least a major population of human thymus-derived lymphocytes under certain conditions will form nonimmune rosettes with sheep red blood cells (SRBC), and it is suggested that these ro settes are formed by a rapidly released or metabolized receptor substance on the living cell surface which behaves as a trypsin-sensitive structure produced by the cells themselves.
Journal ArticleDOI
Immunization of dissociated spleen cell cultures from normal mice
TL;DR: There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
Journal ArticleDOI
Microfilaments in Cellular and Developmental Processes
Norman K. Wessells,Brian S. Spooner,J. F. Ash,M. O. Bradley,Marilyn A. Ludueña,E. L. Taylor,Joan T. Wrenn,Kenneth M. Yamada +7 more
TL;DR: The overall conclusion is that a broad spectrum of cellular and developmental processes are caused by contractile apparatuses that have at least the common feature of being sensitive to cytochalasin.
Journal Article
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.
TL;DR: The in vitro cytotoxic effect of spleen cells of mice immunized by tumour allografts was studied by measuring target cell inactivation as a function of release of radioactive label (51Cr) or loss of cloning efficiency.
Journal ArticleDOI
A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization.
TL;DR: A population of lymphoid cells from several animal species, including man, was identified through a membrane receptor which binds sheep red blood cells treated with antibody and complement, and these cells could be distinguished by their different abilities to bind EAC, CRL and non-CRL from mouse lymphoid organs.
Related Papers (5)
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.
Harvey Cantor,Edward A. Boyse +1 more