Journal ArticleDOI
A safe production method for acetone cyanohydrin
TLDR
In this article, an easily amenable method was presented to produce acetone cyanohydrin on mole scale (output 39 g/h), using a continuous flow system to overcome the high risks associated with the large-scale use of hydrogen cyanide.About:
This article is published in Tetrahedron Letters.The article was published on 2010-08-11. It has received 28 citations till now. The article focuses on the topics: Acetone cyanohydrin & Cyanide.read more
Citations
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Journal ArticleDOI
Efficient synthesis of cyanohydrin trimethylsilyl ethers via 1,2-chemoselective cyanosilylation of carbonyls
Giacomo Strappaveccia,Daniela Lanari,Dmitri Gelman,Ferdinando Pizzo,Ornelio Rosati,Massimo Curini,Luigi Vaccaro +6 more
TL;DR: A sustainable protocol for the cyanosilylation of carbonyl compounds 1a-g and 3a-m using trimethylsilyl cyanide and triphenylphosphine supported on polystyrene as a catalyst under solvent-free conditions was reported in this paper.
Journal ArticleDOI
Catalyst-Free Strecker Reaction in Water: A Simple and Efficient Protocol Using Acetone Cyanohydrin as Cyanide Source
TL;DR: In this paper, a simple, convenient, and practical method for the synthesis of α-amino nitriles through a one-pot, three-component Strecker reaction of a carbonyl compound, amine, and acetone cyanohydrin in water has been developed.
Journal ArticleDOI
Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow
TL;DR: In this article, an efficient, catalyst-free continuous flow procedure for the condensation of acid chlorides and alcohols was developed, which is performed solventless for liquid reagents but requires a solvent for solid reagents in order to prevent clogging of the microreactor.
Journal ArticleDOI
Application of microfluidics technology in chemical engineering for enhanced safety
TL;DR: In this paper, a review of the latest progress in the study of using microreactors to reduce associated risk when performing experiments is presented, and the major consideration to employ microfluidic technology, for example, fast heat/mass transfer, tolerance to high pressure, and confinement of toxic materials.
Journal ArticleDOI
Kinetics and mechanism of the racemic addition of trimethylsilyl cyanide to aldehydes catalysed by Lewis bases.
TL;DR: Tetrabutylammonium thiocyanate is shown to be an excellent catalyst for the synthesis of cyanohydrin trimethylsilyl ethers on a preparative scale and for the formation of hypervalent silicon species.
References
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Journal ArticleDOI
Continuous Flow Reactors, a Tool for the Modern Synthetic Chemist
Charlotte Wiles,Paul Watts +1 more
TL;DR: Microreview as mentioned in this paper focuses on recent developments made in the field of micro reaction technology, highlighting the advantages associated with its use through the synthesis of a diverse array of molecules and highlights the potential of a compound, however, depends not only on structural complexity, but also on the ability to prepare the compound via a scalable synthetic pathway.
Journal ArticleDOI
Organocatalytic asymmetric Diels-Alder reactions of 3-vinylindoles.
TL;DR: This work presents the development of an unprecedented catalytic asymmetric Diels–Alder reaction of 3-vinylindoles 1 with different representative dienophiles 2 (Scheme 1).
Journal ArticleDOI
Acetone cyanohydrin as a source of HCN in the Cu-catalyzed hydrocyanation of alpha-aryl diazoacetates.
TL;DR: It was found that the addition of trimethylsilyl cyanide (TMSCN) significantly accelerates the conversion presumably by delivering free cyanide ion in situ, thus producing various types of alpha-aryl cyanoacetates in high yields under mild conditions.
Book ChapterDOI
Microreactor Technology as an Efficient Tool for Multicomponent Reactions
TL;DR: An overview of the reported examples in which the microreactor technology and the multicomponent approach are combined, usually with dramatically improved results compared to those previously reported can be found in this paper.
Journal ArticleDOI
Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.
Stephen Patterson,Deuan C. Jones,Emma Shanks,Julie A. Frearson,Ian H. Gilbert,Paul G. Wyatt,Alan H. Fairlamb +6 more
TL;DR: Thirty two analogues of phencyclidine were synthesised and tested as inhibitors of trypanothione reductase (TryR), a potential drug target in trypanosome and leishmania parasites, and analogues with improved enzymatic and biological activity were obtained.