A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease.
Daniel M. Corcos,Julie A. Robichaud,Fabian J. David,Sue Leurgans,David E. Vaillancourt,Cynthia Poon,Miriam R. Rafferty,Wendy M. Kohrt,Cynthia L. Comella +8 more
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TLDR
PRE demonstrated a statistically and clinically significant reduction in UPDRS‐III scores compared with mFC and is recommended as a useful adjunct therapy to improve Parkinsonian motor signs.Abstract:
The effects of progressive resistance exercise (PRE) on the motor signs of Parkinson's disease have not been studied in controlled trials. The objective of the current trial was to compare 6-, 12-, 18-, and 24-month outcomes of patients with Parkinson's disease who received PRE with a stretching, balance, and strengthening exercise program. The authors conducted a randomized controlled trial between September 2007 and July 2011. Pairs of patients matched by sex and off-medication scores on the Unified Parkinson's Disease Rating Scale, motor subscale (UPDRS-III), were randomly assigned to the interventions with a 1:1 allocation ratio. The PRE group performed a weight-lifting program. The modified fitness counts (mFC) group performed a stretching, balance, and strengthening exercise program. Patients exercised 2 days per week for 24 months at a gym. A personal trainer directed both weekly sessions for the first 6 months and 1 weekly session after 6 months. The primary outcome was the off-medication UPDRS-III score. Patients were followed for 24 months at 6-month intervals. Of 51 patients, 20 in the PRE group and 18 in the mFC group completed the trial. At 24 months, the mean off-medication UPDRS-III score decreased more with PRE than with mFC (mean difference, -7.3 points; 95% confidence interval, -11.3 to -3.6; P<0.001). The PRE group had 10 adverse events, and the mFC group had 7 adverse events. PRE demonstrated a statistically and clinically significant reduction in UPDRS-III scores compared with mFC and is recommended as a useful adjunct therapy to improve Parkinsonian motor signs. © 2013 Movement Disorder Society.read more
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Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats.
Gusthavo Rodrigues,Thamyris Reis Moraes,Lívia Maria Silvestre Elisei,Iago Henrique Silva Malta,Rafaela dos Santos,Rômulo Dias Novaes,Pablo Christiano Barboza Lollo,Giovane Galdino +7 more
TL;DR: In this article, the authors evaluated the effect of a resistance exercise training protocol combined or not with whey protein supplementation on mechanical allodynia induced by muscle injury and investigated the involvement of spinal glial cells in this process.
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Detraining Slows and Maintenance Training Over 6 Years Halts Parkinsonian Symptoms-Progression
Tibor Hortobágyi,Dávid Sipos,Dávid Sipos,Gábor Borbély,György Áfra,Emese Reichardt-Varga,Gergely Sántha,Ward Nieboer,Katalin Tamási,József Tollár +9 more
TL;DR: In this article, a short-term, high-intensity sensorimotor agility exercise program was designed to improve postural stability of patients with Parkinson's disease and lower drug dose.
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Comparing effect of tai chi and Pilates exercises on static and dynamic balance of elderly men with Parkinson's disease
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Efectividad del trabajo de resistencia y de cicloergómetro a alta velocidad sobre la bradicinesia en la enfermedad de Parkinson: revisión sistemática
F.M. Molina Palomino,López López,J. Rodríguez Torres,M. Granados Santiago,A. Ortiz Rubio,I. Cabrera Martos,Marie Carmen Valenza +6 more
TL;DR: In this article, ejercicios de resistencia and of cicloergometro a alta intensidad have been used for tratar bradicinesia in the enfermedad de Parkinson (EP).
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Methodology of exercise resources development for professionals providing services for people with Parkinson’s: a technical report
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